An antisense oligodeoxynucleotide to μ-opioid receptors inhibits μ-opioid receptor agonist-induced analgesia in rats

We examined effects of an antisense oligodeoxynucleotide against the μ-opioid receptor on μ-opioid receptor agonist-induced antinociception in the cold water (−3°C) tail-flick test in rats. Rats were injected intracerebroventricularly (i.c.v.) with an antisense, sense or missense oligodeoxynucleotid...

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Veröffentlicht in:	European journal of pharmacology 1995-02, Vol.275 (1), p.105-108
Hauptverfasser:	Chen, Xiao-Hong, Adams, Jill U., Geller, Ellen B., DeRiel, J.Kim, Adler, Martin W., Liu-Chen, Lee-Yuan
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesia Analgesics Analgesics - administration & dosage Analgesics - pharmacology Analysis of Variance Animals Antisense oligodeoxynucleotide Base Sequence Benzamides - administration & dosage Benzamides - pharmacology Biological and medical sciences Cerebrospinal Fluid - metabolism Cold water tail-flick test Endorphins - administration & dosage Endorphins - pharmacology Injections, Intraventricular Injections, Subcutaneous Male Medical sciences Molecular Sequence Data Morphine - administration & dosage Morphine - pharmacology Neuropharmacology Oligonucleotides, Antisense - administration & dosage Oligonucleotides, Antisense - chemistry Oligonucleotides, Antisense - pharmacology Pharmacology. Drug treatments Piperazines - administration & dosage Piperazines - pharmacology Pyrrolidines - administration & dosage Pyrrolidines - pharmacology Random Allocation Rat Rats Rats, Sprague-Dawley Receptors, Opioid, delta - agonists Receptors, Opioid, kappa - agonists Receptors, Opioid, mu - agonists μ-Opioid receptor
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