Effects of Potential Damaging Agents on the Microclimate-pH in the Rat Jejunum

This study was designed to determine the pH of the intestinal surface in the rat jejunum in an attempt to investigate the effect of potential damaging agents on the microclimate-pH. A significant pH gradient was observed between the mucosal surface and the bulk phase; however, the microclimate-pH us...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1986-12, Vol.75 (12), p.1162-1165
Hauptverfasser:	Iwatsubo, Takafumi, Miyamoto, Yusei, Sugiyama, Yuichi, Yuasa, Hiroaki, Iga, Tatsuji, Hanano, Manabu
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetazolamide - pharmacology Acetylcysteine - pharmacology Amiloride - pharmacology Animals Aspirin - pharmacology Biological and medical sciences Chlorpromazine - pharmacology Drug toxicity and drugs side effects treatment Glucose - pharmacology In Vitro Techniques Intestinal Mucosa - drug effects Jejunum - drug effects Medical sciences Ouabain - pharmacology Pharmacology. Drug treatments Rats Rats, Inbred Strains Taurocholic Acid - pharmacology Toxicity: digestive system
Online-Zugang:	Volltext
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