Differential regulation of G protein α‐subunit GTPase activity by peptides derived from the third cytoplasmic loop of the α 2‐adrenergic receptor

The effect of peptides homologous to segments of a G protein‐coupled receptor on the GTPase activity of recombinant G0α (rGoα) and G,a (rGsα) has been tested. These peptides contain overlapping sequences spanning from amino acid 212 of the putative fifth transmembrane domain to amino acid 229 of the...

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Veröffentlicht in:	FEBS letters 1995-05, Vol.365 (1), p.13-17
Hauptverfasser:	Wagner, Thomas, Oppi, Cristina, Tocchini Valentini, Glauco P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence CD spectroscopy Circular Dichroism Dose-Response Relationship, Drug G protein α-subunit GTP Phosphohydrolases - drug effects GTP Phosphohydrolases - genetics GTP Phosphohydrolases - metabolism GTP-Binding Proteins - drug effects GTP-Binding Proteins - genetics GTP-Binding Proteins - metabolism GTPase activity Guanosine Triphosphate - metabolism Lysophosphatidylcholines - pharmacology Molecular Sequence Data Peptide Fragments - chemistry Peptide Fragments - pharmacology Protein Conformation Receptorial peptide Receptors, Adrenergic, alpha-2 - chemistry Recombinant Proteins - drug effects Recombinant Proteins - metabolism
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