Pulsatile release of immunoreactive luteinizing hormone (irLH) in hypophysectomized male rats
The concentration of plasma luteinizing hormone (LH) was monitored every minute by radioimmunoassay in male rats that were either hypophysectomized, or castrated and hypophysectomized. Castrated rats showed a pulsatile fluctuation of plasma immunoreactive LH (irLH) concentration with an elevated bas...
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| Veröffentlicht in: | Biology of reproduction 1986-12, Vol.35 (5), p.1115-1122 |
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| container_issue | 5 |
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| container_title | Biology of reproduction |
| container_volume | 35 |
| creator | SHIN, S. H VINCENT, S. G MALTMAN, C OBONSAWIN, M. C STOKREEF, J. C REIFEL, C. W |
| description | The concentration of plasma luteinizing hormone (LH) was monitored every minute by radioimmunoassay in male rats that were
either hypophysectomized, or castrated and hypophysectomized. Castrated rats showed a pulsatile fluctuation of plasma immunoreactive
LH (irLH) concentration with an elevated basal level, confirming previous work. The hypophysectomized and castrated hypophysectomized
rats also showed pulsatile changes in plasma irLH concentration. This unexpected result indicates that ectopic irLH is not
only actively released after hypophysectomy, but is released in pulses. The pulse interval was approximately 20 minutes for
all 3 groups. The slope of the rate of decline of plasma irLH in the castrated rats is parallel to a theoretical disappearance
rate of 5 min, while these slopes in the hypophysectomized and castrated hypophysectomized rats correspond to a 1 to 2-min
disappearance rate. The difference in these slopes implies that the two irLH molecules may not be identical. |
| doi_str_mv | 10.1095/biolreprod35.5.1115 |
| format | Article |
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either hypophysectomized, or castrated and hypophysectomized. Castrated rats showed a pulsatile fluctuation of plasma immunoreactive
LH (irLH) concentration with an elevated basal level, confirming previous work. The hypophysectomized and castrated hypophysectomized
rats also showed pulsatile changes in plasma irLH concentration. This unexpected result indicates that ectopic irLH is not
only actively released after hypophysectomy, but is released in pulses. The pulse interval was approximately 20 minutes for
all 3 groups. The slope of the rate of decline of plasma irLH in the castrated rats is parallel to a theoretical disappearance
rate of 5 min, while these slopes in the hypophysectomized and castrated hypophysectomized rats correspond to a 1 to 2-min
disappearance rate. The difference in these slopes implies that the two irLH molecules may not be identical.</description><identifier>ISSN: 0006-3363</identifier><identifier>EISSN: 1529-7268</identifier><identifier>DOI: 10.1095/biolreprod35.5.1115</identifier><identifier>PMID: 3828427</identifier><identifier>CODEN: BIREBV</identifier><language>eng</language><publisher>Madison, WI: Society for the Study of Reproduction</publisher><subject>Animals ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Hormone metabolism and regulation ; Hypophysectomy ; Kinetics ; Luteinizing Hormone - blood ; Luteinizing Hormone - metabolism ; Male ; Mammalian male genital system ; Orchiectomy ; Radioimmunoassay ; Rats ; Rats, Inbred Strains ; Vertebrates: reproduction</subject><ispartof>Biology of reproduction, 1986-12, Vol.35 (5), p.1115-1122</ispartof><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8257033$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3828427$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>SHIN, S. H</creatorcontrib><creatorcontrib>VINCENT, S. G</creatorcontrib><creatorcontrib>MALTMAN, C</creatorcontrib><creatorcontrib>OBONSAWIN, M. C</creatorcontrib><creatorcontrib>STOKREEF, J. C</creatorcontrib><creatorcontrib>REIFEL, C. W</creatorcontrib><title>Pulsatile release of immunoreactive luteinizing hormone (irLH) in hypophysectomized male rats</title><title>Biology of reproduction</title><addtitle>Biol Reprod</addtitle><description>The concentration of plasma luteinizing hormone (LH) was monitored every minute by radioimmunoassay in male rats that were
either hypophysectomized, or castrated and hypophysectomized. Castrated rats showed a pulsatile fluctuation of plasma immunoreactive
LH (irLH) concentration with an elevated basal level, confirming previous work. The hypophysectomized and castrated hypophysectomized
rats also showed pulsatile changes in plasma irLH concentration. This unexpected result indicates that ectopic irLH is not
only actively released after hypophysectomy, but is released in pulses. The pulse interval was approximately 20 minutes for
all 3 groups. The slope of the rate of decline of plasma irLH in the castrated rats is parallel to a theoretical disappearance
rate of 5 min, while these slopes in the hypophysectomized and castrated hypophysectomized rats correspond to a 1 to 2-min
disappearance rate. The difference in these slopes implies that the two irLH molecules may not be identical.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hormone metabolism and regulation</subject><subject>Hypophysectomy</subject><subject>Kinetics</subject><subject>Luteinizing Hormone - blood</subject><subject>Luteinizing Hormone - metabolism</subject><subject>Male</subject><subject>Mammalian male genital system</subject><subject>Orchiectomy</subject><subject>Radioimmunoassay</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Vertebrates: reproduction</subject><issn>0006-3363</issn><issn>1529-7268</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkcFqGzEQhkVocRw3TxACOpSSHtaVNNJKPhbTxAVDcmiPZZF3Z70K2pUj7dbYT981Mc0xpxn4P_6Bbwi54WzO2UJ927jgI-5iqEDN1Zxzri7IlCuxyLTIzQcyZYzlGUAOl-QqpWfGuAQBEzIBI4wUekr-PA0-2d55pBE92oQ01NS17dCFiLbs3V-kfujRde7oui1tQmxDh_TOxfXqK3UdbQ67sGsOCcs-tO6IFW3tqc726RP5WFuf8Po8Z-T3_Y9fy1W2fnz4ufy-zhqx0H1WSl5izmvDUSncSJRc5lBVPLegFQchS6FRy1pAJSpjFDO2Elac9g0sapiRL6-9o4yXAVNftC6V6L3tMAyp0BqY5tK8C3KpDEgFI3h7BodNi1Wxi6618VCcxY3553NuU2l9HW1XuvQfM0JpBvB2r3HbZu8iFmmU48dSKPb7PahCFae_wT_Aroyw</recordid><startdate>19861201</startdate><enddate>19861201</enddate><creator>SHIN, S. H</creator><creator>VINCENT, S. G</creator><creator>MALTMAN, C</creator><creator>OBONSAWIN, M. C</creator><creator>STOKREEF, J. C</creator><creator>REIFEL, C. W</creator><general>Society for the Study of Reproduction</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19861201</creationdate><title>Pulsatile release of immunoreactive luteinizing hormone (irLH) in hypophysectomized male rats</title><author>SHIN, S. H ; VINCENT, S. G ; MALTMAN, C ; OBONSAWIN, M. C ; STOKREEF, J. C ; REIFEL, C. W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h297t-c41ce61f81e55eb4e41463dd16a3751324c27e74f23d2d88508ad2a22d88b39f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hormone metabolism and regulation</topic><topic>Hypophysectomy</topic><topic>Kinetics</topic><topic>Luteinizing Hormone - blood</topic><topic>Luteinizing Hormone - metabolism</topic><topic>Male</topic><topic>Mammalian male genital system</topic><topic>Orchiectomy</topic><topic>Radioimmunoassay</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SHIN, S. H</creatorcontrib><creatorcontrib>VINCENT, S. G</creatorcontrib><creatorcontrib>MALTMAN, C</creatorcontrib><creatorcontrib>OBONSAWIN, M. C</creatorcontrib><creatorcontrib>STOKREEF, J. C</creatorcontrib><creatorcontrib>REIFEL, C. W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Biology of reproduction</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SHIN, S. H</au><au>VINCENT, S. G</au><au>MALTMAN, C</au><au>OBONSAWIN, M. C</au><au>STOKREEF, J. C</au><au>REIFEL, C. W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pulsatile release of immunoreactive luteinizing hormone (irLH) in hypophysectomized male rats</atitle><jtitle>Biology of reproduction</jtitle><addtitle>Biol Reprod</addtitle><date>1986-12-01</date><risdate>1986</risdate><volume>35</volume><issue>5</issue><spage>1115</spage><epage>1122</epage><pages>1115-1122</pages><issn>0006-3363</issn><eissn>1529-7268</eissn><coden>BIREBV</coden><abstract>The concentration of plasma luteinizing hormone (LH) was monitored every minute by radioimmunoassay in male rats that were
either hypophysectomized, or castrated and hypophysectomized. Castrated rats showed a pulsatile fluctuation of plasma immunoreactive
LH (irLH) concentration with an elevated basal level, confirming previous work. The hypophysectomized and castrated hypophysectomized
rats also showed pulsatile changes in plasma irLH concentration. This unexpected result indicates that ectopic irLH is not
only actively released after hypophysectomy, but is released in pulses. The pulse interval was approximately 20 minutes for
all 3 groups. The slope of the rate of decline of plasma irLH in the castrated rats is parallel to a theoretical disappearance
rate of 5 min, while these slopes in the hypophysectomized and castrated hypophysectomized rats correspond to a 1 to 2-min
disappearance rate. The difference in these slopes implies that the two irLH molecules may not be identical.</abstract><cop>Madison, WI</cop><pub>Society for the Study of Reproduction</pub><pmid>3828427</pmid><doi>10.1095/biolreprod35.5.1115</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | Biology of reproduction, 1986-12, Vol.35 (5), p.1115-1122 |
| issn | 0006-3363 1529-7268 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77307148 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Animals Biological and medical sciences Fundamental and applied biological sciences. Psychology Hormone metabolism and regulation Hypophysectomy Kinetics Luteinizing Hormone - blood Luteinizing Hormone - metabolism Male Mammalian male genital system Orchiectomy Radioimmunoassay Rats Rats, Inbred Strains Vertebrates: reproduction |
| title | Pulsatile release of immunoreactive luteinizing hormone (irLH) in hypophysectomized male rats |
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