A New Synthesis of 7H-Pyrido[1, 2, 3-de][1, 4]benzoxazine Derivatives Including an Antibacterial Agent, Ofloxacin

A new method for the synthesis of 7H-pyrido[1, 2, 3-de][1, 4]benzoxazine derivatives was developed. The method is characterized by the intramolecular cyclization of 1-(1-hydroxyprop-2-yl)-8-fluoro-4-quinolones which are prepared in three or four steps from ethyl 2, 3, 4, 5-tetrafluoro-benzoylacetate...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 1986/10/25, Vol.34(10), pp.4098-4102
Hauptverfasser:	EGAWA, HIROSHI, MIYAMOTO, TERUYUKI, MATSUMOTO, JUN-ICHI
Format:	Artikel
Sprache:	eng
Schlagworte:	Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Ofloxacin Organic chemistry Oxazines - chemical synthesis Preparations and properties Pyridines - chemical synthesis
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container_title	Chemical & pharmaceutical bulletin
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creator	EGAWA, HIROSHI MIYAMOTO, TERUYUKI MATSUMOTO, JUN-ICHI
description	A new method for the synthesis of 7H-pyrido[1, 2, 3-de][1, 4]benzoxazine derivatives was developed. The method is characterized by the intramolecular cyclization of 1-(1-hydroxyprop-2-yl)-8-fluoro-4-quinolones which are prepared in three or four steps from ethyl 2, 3, 4, 5-tetrafluoro-benzoylacetate. As an application of this method, ofloxacin, an antibacterial agent, was synthesized.
doi_str_mv	10.1248/cpb.34.4098
format	Article
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subjects	Chemistry Exact sciences and technology Heterocyclic compounds Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms Ofloxacin Organic chemistry Oxazines - chemical synthesis Preparations and properties Pyridines - chemical synthesis
title	A New Synthesis of 7H-Pyrido[1, 2, 3-de][1, 4]benzoxazine Derivatives Including an Antibacterial Agent, Ofloxacin
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