Decreased Teicoplanin Susceptibility of Methicillin-Resistant Strains of Staphylococcus aureus
Between February 1992 and February 1993, 12 patients were seen who were infected or colonized with methicillin-resistant strains of Staphylococcus aureus. The strains had decreased susceptibility to teicoplanin (MICs, 8–16 µg/mL). Field inversion gel electrophoresis showed the strains belonged to th...
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| Veröffentlicht in: | The Journal of infectious diseases 1995-06, Vol.171 (6), p.1646-1650 |
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| container_title | The Journal of infectious diseases |
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| creator | Mainardi, Jean-Luc Shlaes, David M. Goering, Richard V. Shlaes, Janet H. Acar, Jacques F. Goldstein, Fred W. |
| description | Between February 1992 and February 1993, 12 patients were seen who were infected or colonized with methicillin-resistant strains of Staphylococcus aureus. The strains had decreased susceptibility to teicoplanin (MICs, 8–16 µg/mL). Field inversion gel electrophoresis showed the strains belonged to three related clones (A1, A2, and A3). The patients were thought to have acquired the strains nosocomially. Consistent with results of laboratory studies of teicoplanin-resistant S. aureus, all but 1 strain expressed a 35-kDa membrane protein, and 9 strains expressed increased levels of penicillin-binding protein 2 complex. Six strains were isolated from patients treated with glycopeptides. These data suggest that nosocomial transmission of S. aureus with decreased teicoplanin susceptibility may occur during glycopeptide use and that such strains develop resistance by a mechanism associated with the appearance of a 35-kDa membrane protein. Surveillance is necessary to monitor for the potential selection of resistant clones that may be capable of dissemination. |
| doi_str_mv | 10.1093/infdis/171.6.1646 |
| format | Article |
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The strains had decreased susceptibility to teicoplanin (MICs, 8–16 µg/mL). Field inversion gel electrophoresis showed the strains belonged to three related clones (A1, A2, and A3). The patients were thought to have acquired the strains nosocomially. Consistent with results of laboratory studies of teicoplanin-resistant S. aureus, all but 1 strain expressed a 35-kDa membrane protein, and 9 strains expressed increased levels of penicillin-binding protein 2 complex. Six strains were isolated from patients treated with glycopeptides. These data suggest that nosocomial transmission of S. aureus with decreased teicoplanin susceptibility may occur during glycopeptide use and that such strains develop resistance by a mechanism associated with the appearance of a 35-kDa membrane protein. Surveillance is necessary to monitor for the potential selection of resistant clones that may be capable of dissemination.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/171.6.1646</identifier><identifier>PMID: 7769310</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Adult ; Aged ; Antibacterial agents ; Antibiotics ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antimicrobials ; Bacterial Proteins - chemistry ; beta-Lactam Resistance ; Biological and medical sciences ; Concise Communications ; Cross Infection ; DNA, Bacterial - chemistry ; Dosage ; Electrophoresis ; Electrophoresis, Gel, Pulsed-Field ; Female ; Gels ; Glycopeptides ; Humans ; Infections ; Male ; Medical sciences ; Membrane proteins ; Membrane Proteins - chemistry ; Microbial Sensitivity Tests ; Middle Aged ; Molecular Weight ; Pharmacology. 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The strains had decreased susceptibility to teicoplanin (MICs, 8–16 µg/mL). Field inversion gel electrophoresis showed the strains belonged to three related clones (A1, A2, and A3). The patients were thought to have acquired the strains nosocomially. Consistent with results of laboratory studies of teicoplanin-resistant S. aureus, all but 1 strain expressed a 35-kDa membrane protein, and 9 strains expressed increased levels of penicillin-binding protein 2 complex. Six strains were isolated from patients treated with glycopeptides. These data suggest that nosocomial transmission of S. aureus with decreased teicoplanin susceptibility may occur during glycopeptide use and that such strains develop resistance by a mechanism associated with the appearance of a 35-kDa membrane protein. Surveillance is necessary to monitor for the potential selection of resistant clones that may be capable of dissemination.</description><subject>Adult</subject><subject>Aged</subject><subject>Antibacterial agents</subject><subject>Antibiotics</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antimicrobials</subject><subject>Bacterial Proteins - chemistry</subject><subject>beta-Lactam Resistance</subject><subject>Biological and medical sciences</subject><subject>Concise Communications</subject><subject>Cross Infection</subject><subject>DNA, Bacterial - chemistry</subject><subject>Dosage</subject><subject>Electrophoresis</subject><subject>Electrophoresis, Gel, Pulsed-Field</subject><subject>Female</subject><subject>Gels</subject><subject>Glycopeptides</subject><subject>Humans</subject><subject>Infections</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Membrane proteins</subject><subject>Membrane Proteins - chemistry</subject><subject>Microbial Sensitivity Tests</subject><subject>Middle Aged</subject><subject>Molecular Weight</subject><subject>Pharmacology. Drug treatments</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus aureus - drug effects</subject><subject>Staphylococcus aureus - genetics</subject><subject>Teicoplanin - pharmacology</subject><subject>Urine</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1O3DAURi1URAfaB-gCKYuquwy-cWzHy2ooBYmftjMVVRe1HMcWppkktR2JeXs8TIBlV16c7372PUboA-A5YEFOXGcbF06Aw5zNgZVsD82AEp4zBuQNmmFcFDlUQrxFhyHcY4xLwvgBOuCcCQJ4hv6cGu2NCqbJVsbpfmhV57psOQZthuhq17q4yXqbXZl457RrW9flP0xwIaouZsvolevCNrCMarjbtL3utR5DpkZvxvAO7VvVBvN-Oo_Qz7Mvq8V5fnnz9WLx-TLXJRUxpxZXAkiJSyUoLYgAWtOytoAxAyiquuGk0cYqaEBzqxtMKqUUcM2qsmAVOUKfdr2D7_-NJkS5dmmDNm1j-jFIzglmBWH_DQITjOCKpyDsgtr3IXhj5eDdWvmNBCy38uVOvkzyJZNb-WnmeCof67VpXiYm24l_nLgKWrXWq06nhucYoemBT1dPNfch9v4VYyCUCpF4vuPpE8zDC1f-r2SccCrPf_2W38Tq-_Xt4lSekUfLPafl</recordid><startdate>19950601</startdate><enddate>19950601</enddate><creator>Mainardi, Jean-Luc</creator><creator>Shlaes, David M.</creator><creator>Goering, Richard V.</creator><creator>Shlaes, Janet H.</creator><creator>Acar, Jacques F.</creator><creator>Goldstein, Fred W.</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>19950601</creationdate><title>Decreased Teicoplanin Susceptibility of Methicillin-Resistant Strains of Staphylococcus aureus</title><author>Mainardi, Jean-Luc ; Shlaes, David M. ; Goering, Richard V. ; Shlaes, Janet H. ; Acar, Jacques F. ; Goldstein, Fred W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-5f08913404a95523915b54bf10061128bd73dcefa1d1c7fcd038aaa17c6842683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antibacterial agents</topic><topic>Antibiotics</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antimicrobials</topic><topic>Bacterial Proteins - chemistry</topic><topic>beta-Lactam Resistance</topic><topic>Biological and medical sciences</topic><topic>Concise Communications</topic><topic>Cross Infection</topic><topic>DNA, Bacterial - chemistry</topic><topic>Dosage</topic><topic>Electrophoresis</topic><topic>Electrophoresis, Gel, Pulsed-Field</topic><topic>Female</topic><topic>Gels</topic><topic>Glycopeptides</topic><topic>Humans</topic><topic>Infections</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Membrane proteins</topic><topic>Membrane Proteins - chemistry</topic><topic>Microbial Sensitivity Tests</topic><topic>Middle Aged</topic><topic>Molecular Weight</topic><topic>Pharmacology. Drug treatments</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus aureus - drug effects</topic><topic>Staphylococcus aureus - genetics</topic><topic>Teicoplanin - pharmacology</topic><topic>Urine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mainardi, Jean-Luc</creatorcontrib><creatorcontrib>Shlaes, David M.</creatorcontrib><creatorcontrib>Goering, Richard V.</creatorcontrib><creatorcontrib>Shlaes, Janet H.</creatorcontrib><creatorcontrib>Acar, Jacques F.</creatorcontrib><creatorcontrib>Goldstein, Fred W.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mainardi, Jean-Luc</au><au>Shlaes, David M.</au><au>Goering, Richard V.</au><au>Shlaes, Janet H.</au><au>Acar, Jacques F.</au><au>Goldstein, Fred W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Decreased Teicoplanin Susceptibility of Methicillin-Resistant Strains of Staphylococcus aureus</atitle><jtitle>The Journal of infectious diseases</jtitle><addtitle>J Infect Dis</addtitle><date>1995-06-01</date><risdate>1995</risdate><volume>171</volume><issue>6</issue><spage>1646</spage><epage>1650</epage><pages>1646-1650</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>Between February 1992 and February 1993, 12 patients were seen who were infected or colonized with methicillin-resistant strains of Staphylococcus aureus. The strains had decreased susceptibility to teicoplanin (MICs, 8–16 µg/mL). Field inversion gel electrophoresis showed the strains belonged to three related clones (A1, A2, and A3). The patients were thought to have acquired the strains nosocomially. Consistent with results of laboratory studies of teicoplanin-resistant S. aureus, all but 1 strain expressed a 35-kDa membrane protein, and 9 strains expressed increased levels of penicillin-binding protein 2 complex. Six strains were isolated from patients treated with glycopeptides. These data suggest that nosocomial transmission of S. aureus with decreased teicoplanin susceptibility may occur during glycopeptide use and that such strains develop resistance by a mechanism associated with the appearance of a 35-kDa membrane protein. Surveillance is necessary to monitor for the potential selection of resistant clones that may be capable of dissemination.</abstract><cop>Chicago, IL</cop><pub>The University of Chicago Press</pub><pmid>7769310</pmid><doi>10.1093/infdis/171.6.1646</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aged Antibacterial agents Antibiotics Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobials Bacterial Proteins - chemistry beta-Lactam Resistance Biological and medical sciences Concise Communications Cross Infection DNA, Bacterial - chemistry Dosage Electrophoresis Electrophoresis, Gel, Pulsed-Field Female Gels Glycopeptides Humans Infections Male Medical sciences Membrane proteins Membrane Proteins - chemistry Microbial Sensitivity Tests Middle Aged Molecular Weight Pharmacology. Drug treatments Staphylococcus aureus Staphylococcus aureus - drug effects Staphylococcus aureus - genetics Teicoplanin - pharmacology Urine |
| title | Decreased Teicoplanin Susceptibility of Methicillin-Resistant Strains of Staphylococcus aureus |
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