Heat stability of the antimicrobial activity of sixty-two antibacterial agents
Sixty-two antimicrobial agents, including several combinations, were examined for stability at 56°C for 30min and 121°C for 15min, respectively. A microtiter broth dilution MIC test and an agar disk diffusion test served to test eachchemo-agent for residual antimicrobial activity. Eleven drugs were...
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| Veröffentlicht in: | Journal of antimicrobial chemotherapy 1995-01, Vol.35 (1), p.149-154 |
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| container_title | Journal of antimicrobial chemotherapy |
| container_volume | 35 |
| creator | Traub, Walter H. Leonhard, Birgit |
| description | Sixty-two antimicrobial agents, including several combinations, were examined for stability at 56°C for 30min and 121°C for 15min, respectively. A microtiter broth dilution MIC test and an agar disk diffusion test served to test eachchemo-agent for residual antimicrobial activity. Eleven drugs were partially heat-labile (MICs raised four- to eight-fold after autoclaving) and 26 drugs were heat-labile (MICs raised≥ 16-fold following autoclaving); the remainder proved heat-stable (MICs raised ≤ two-fold after autoclaving). Surprisingly, the β-lactams, azlocillin, aztreonam, mezlocillin, and oxacillin, were remarkably heat-stable. |
| doi_str_mv | 10.1093/jac/35.1.149 |
| format | Article |
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A microtiter broth dilution MIC test and an agar disk diffusion test served to test eachchemo-agent for residual antimicrobial activity. Eleven drugs were partially heat-labile (MICs raised four- to eight-fold after autoclaving) and 26 drugs were heat-labile (MICs raised≥ 16-fold following autoclaving); the remainder proved heat-stable (MICs raised ≤ two-fold after autoclaving). Surprisingly, the β-lactams, azlocillin, aztreonam, mezlocillin, and oxacillin, were remarkably heat-stable.</description><identifier>ISSN: 0305-7453</identifier><identifier>EISSN: 1460-2091</identifier><identifier>DOI: 10.1093/jac/35.1.149</identifier><identifier>PMID: 7768762</identifier><identifier>CODEN: JACHDX</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>Acinetobacter baumannii ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Antibacterial agents ; Antibiotics. Antiinfectious agents. 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A microtiter broth dilution MIC test and an agar disk diffusion test served to test eachchemo-agent for residual antimicrobial activity. Eleven drugs were partially heat-labile (MICs raised four- to eight-fold after autoclaving) and 26 drugs were heat-labile (MICs raised≥ 16-fold following autoclaving); the remainder proved heat-stable (MICs raised ≤ two-fold after autoclaving). Surprisingly, the β-lactams, azlocillin, aztreonam, mezlocillin, and oxacillin, were remarkably heat-stable.</description><subject>Acinetobacter baumannii</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antibacterial agents</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Bacillus subtilis</subject><subject>Bacteria - drug effects</subject><subject>Biological and medical sciences</subject><subject>Culture Media</subject><subject>Drug Stability</subject><subject>Escherichia coli</subject><subject>Hot Temperature</subject><subject>Medical sciences</subject><subject>Microbial Sensitivity Tests</subject><subject>Pharmacology. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Bacillus subtilis</topic><topic>Bacteria - drug effects</topic><topic>Biological and medical sciences</topic><topic>Culture Media</topic><topic>Drug Stability</topic><topic>Escherichia coli</topic><topic>Hot Temperature</topic><topic>Medical sciences</topic><topic>Microbial Sensitivity Tests</topic><topic>Pharmacology. 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A microtiter broth dilution MIC test and an agar disk diffusion test served to test eachchemo-agent for residual antimicrobial activity. Eleven drugs were partially heat-labile (MICs raised four- to eight-fold after autoclaving) and 26 drugs were heat-labile (MICs raised≥ 16-fold following autoclaving); the remainder proved heat-stable (MICs raised ≤ two-fold after autoclaving). Surprisingly, the β-lactams, azlocillin, aztreonam, mezlocillin, and oxacillin, were remarkably heat-stable.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>7768762</pmid><doi>10.1093/jac/35.1.149</doi><tpages>6</tpages></addata></record> |
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| ispartof | Journal of antimicrobial chemotherapy, 1995-01, Vol.35 (1), p.149-154 |
| issn | 0305-7453 1460-2091 |
| language | eng |
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| source | MEDLINE; Oxford University Press Journals Digital Archive Legacy |
| subjects | Acinetobacter baumannii Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Bacillus subtilis Bacteria - drug effects Biological and medical sciences Culture Media Drug Stability Escherichia coli Hot Temperature Medical sciences Microbial Sensitivity Tests Pharmacology. Drug treatments Sterilization |
| title | Heat stability of the antimicrobial activity of sixty-two antibacterial agents |
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