Calibration of misonidazole labeling by simultaneous measurement of oxygen tension and labeling density in multicellular spheroids

To correlate misonidazole concentrations and oxygen pressures (Po2) at identical locations within EMT6/Ro multi‐cell spheroids (mean diameters ± SD: 867 ± 20 μm), Po2 measurements were performed with oxygen‐sensitive microelectrodes during incubation of these spheroids with tritiated misonidazole (1...

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Veröffentlicht in:	International journal of cancer 1995-05, Vol.61 (4), p.567-573
Hauptverfasser:	Gross, Markus W., Karbach, Ulrich, Groebe, Karlfried, Franko, Allan J., Mueller‐Klieser, Wolfgang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoradiography Biological and medical sciences Calibration Cell Division - physiology Cell Hypoxia Feasibility Studies Host-tumor relations. Immunology. Biological markers Mammary Neoplasms, Experimental - chemistry Mammary Neoplasms, Experimental - metabolism Medical sciences Mice Microelectrodes Misonidazole - analysis Misonidazole - metabolism Misonidazole - pharmacokinetics Oxygen - analysis Oxygen - metabolism Partial Pressure Tritium Tumor Cells, Cultured Tumors
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