Somatostatin analog-induced remission of necrolytic migratory erythema without changes in plasma glucagon concentration
A 41-year-old woman with metastatic glucagonoma and the characteristic disabling rash, necrolytic migratory erythema, was treated with a synthetic somatostatin analog while waiting to undergo curative surgical resection. Plasma glucagon concentration (1,500-3,300 pg/ml, normal less than 200) remaine...
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| Veröffentlicht in: | Pancreas 1986, Vol.1 (5), p.464-469 |
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| container_title | Pancreas |
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| creator | SANTANGELO, W. C UNGER, R. H ORCI, L DUENO, M. I POPMA, J. J KREJS, G. J |
| description | A 41-year-old woman with metastatic glucagonoma and the characteristic disabling rash, necrolytic migratory erythema, was treated with a synthetic somatostatin analog while waiting to undergo curative surgical resection. Plasma glucagon concentration (1,500-3,300 pg/ml, normal less than 200) remained elevated during analog therapy as the rash cleared. Only with surgical resection (partial pancreatectomy and partial hepatectomy) did glucagon levels return to normal. The therapeutic benefit caused by the analog in this syndrome differs from that in other endocrine tumor syndromes such as pancreatic cholera, carcinoid, or gastrinoma where circulating levels of tumor-produced agents are suppressed in conjunction with control of symptoms. |
| doi_str_mv | 10.1097/00006676-198609000-00013 |
| format | Article |
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The therapeutic benefit caused by the analog in this syndrome differs from that in other endocrine tumor syndromes such as pancreatic cholera, carcinoid, or gastrinoma where circulating levels of tumor-produced agents are suppressed in conjunction with control of symptoms.</description><identifier>ISSN: 0885-3177</identifier><identifier>EISSN: 1536-4828</identifier><identifier>DOI: 10.1097/00006676-198609000-00013</identifier><identifier>PMID: 2882503</identifier><identifier>CODEN: PANCE4</identifier><language>eng</language><publisher>Hagerstown, MD: Lippincott Williams & Wilkins</publisher><subject>Adult ; Antineoplastic Agents - therapeutic use ; Biological and medical sciences ; Dermatology ; Erythema - drug therapy ; Erythema - etiology ; Female ; Glucagon - blood ; Glucagonoma - complications ; Glucagonoma - drug therapy ; Glucagonoma - surgery ; Hormones. Endocrine system ; Humans ; Medical sciences ; Octreotide ; Pancreatic Neoplasms - complications ; Pancreatic Neoplasms - drug therapy ; Pancreatic Neoplasms - surgery ; Pharmacology. Drug treatments ; Somatostatin - analogs & derivatives ; Somatostatin - therapeutic use ; Tumors of the skin and soft tissue. 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I</creatorcontrib><creatorcontrib>POPMA, J. J</creatorcontrib><creatorcontrib>KREJS, G. J</creatorcontrib><title>Somatostatin analog-induced remission of necrolytic migratory erythema without changes in plasma glucagon concentration</title><title>Pancreas</title><addtitle>Pancreas</addtitle><description>A 41-year-old woman with metastatic glucagonoma and the characteristic disabling rash, necrolytic migratory erythema, was treated with a synthetic somatostatin analog while waiting to undergo curative surgical resection. Plasma glucagon concentration (1,500-3,300 pg/ml, normal less than 200) remained elevated during analog therapy as the rash cleared. Only with surgical resection (partial pancreatectomy and partial hepatectomy) did glucagon levels return to normal. The therapeutic benefit caused by the analog in this syndrome differs from that in other endocrine tumor syndromes such as pancreatic cholera, carcinoid, or gastrinoma where circulating levels of tumor-produced agents are suppressed in conjunction with control of symptoms.</description><subject>Adult</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Dermatology</subject><subject>Erythema - drug therapy</subject><subject>Erythema - etiology</subject><subject>Female</subject><subject>Glucagon - blood</subject><subject>Glucagonoma - complications</subject><subject>Glucagonoma - drug therapy</subject><subject>Glucagonoma - surgery</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Octreotide</subject><subject>Pancreatic Neoplasms - complications</subject><subject>Pancreatic Neoplasms - drug therapy</subject><subject>Pancreatic Neoplasms - surgery</subject><subject>Pharmacology. Drug treatments</subject><subject>Somatostatin - analogs & derivatives</subject><subject>Somatostatin - therapeutic use</subject><subject>Tumors of the skin and soft tissue. Premalignant lesions</subject><issn>0885-3177</issn><issn>1536-4828</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kMtq3DAUhkVpSadJHqGgRenOjS62JS1LyKUQ6CLN2hxrJI-KLU0lmTBvn9NkMgIhxH85nI8QytkPzoy6Ynj6XvUNN7pnBn8NXi4_kA3vZN-0WuiPZMO07hrJlfpMvpTyFx1KduaMnAmtRcfkhjw_pgVqKhVqiBQizGlqQtyu1m1pdksoJaRIk6fR2ZzmQw2WLmHKGMoH6vKh7twC9DnUXVortTuIkysUy_YzFFSmebUwYYdN0bpYMYmNF-STh7m4y-N7Tp5ub_5c3zcPv-9-Xf98aKzo2trwkXnu9Cjbjillveu5bIXXrLPjCELL3htj2ChG8AC96jTi8R4Eb7doYPKcfH_r3ef0b3WlDriSdfMM0aW1DEoJg5BaNOo3I25ZSnZ-2OewQD4MnA3_mQ_vzIcT8-GVOUa_Hmes4-K2p-ARMurfjjoUC7PPEG0oJ5sWrNVGyxejVIzj</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>SANTANGELO, W. C</creator><creator>UNGER, R. H</creator><creator>ORCI, L</creator><creator>DUENO, M. I</creator><creator>POPMA, J. J</creator><creator>KREJS, G. 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J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c254t-1b0f1e8b345077cfe61342f805cbba2836f9990b2bafaa6758109ffa214dbba03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Adult</topic><topic>Antineoplastic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Dermatology</topic><topic>Erythema - drug therapy</topic><topic>Erythema - etiology</topic><topic>Female</topic><topic>Glucagon - blood</topic><topic>Glucagonoma - complications</topic><topic>Glucagonoma - drug therapy</topic><topic>Glucagonoma - surgery</topic><topic>Hormones. Endocrine system</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Octreotide</topic><topic>Pancreatic Neoplasms - complications</topic><topic>Pancreatic Neoplasms - drug therapy</topic><topic>Pancreatic Neoplasms - surgery</topic><topic>Pharmacology. Drug treatments</topic><topic>Somatostatin - analogs & derivatives</topic><topic>Somatostatin - therapeutic use</topic><topic>Tumors of the skin and soft tissue. Premalignant lesions</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SANTANGELO, W. C</creatorcontrib><creatorcontrib>UNGER, R. H</creatorcontrib><creatorcontrib>ORCI, L</creatorcontrib><creatorcontrib>DUENO, M. I</creatorcontrib><creatorcontrib>POPMA, J. J</creatorcontrib><creatorcontrib>KREJS, G. J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Pancreas</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SANTANGELO, W. C</au><au>UNGER, R. H</au><au>ORCI, L</au><au>DUENO, M. I</au><au>POPMA, J. J</au><au>KREJS, G. J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Somatostatin analog-induced remission of necrolytic migratory erythema without changes in plasma glucagon concentration</atitle><jtitle>Pancreas</jtitle><addtitle>Pancreas</addtitle><date>1986</date><risdate>1986</risdate><volume>1</volume><issue>5</issue><spage>464</spage><epage>469</epage><pages>464-469</pages><issn>0885-3177</issn><eissn>1536-4828</eissn><coden>PANCE4</coden><abstract>A 41-year-old woman with metastatic glucagonoma and the characteristic disabling rash, necrolytic migratory erythema, was treated with a synthetic somatostatin analog while waiting to undergo curative surgical resection. Plasma glucagon concentration (1,500-3,300 pg/ml, normal less than 200) remained elevated during analog therapy as the rash cleared. Only with surgical resection (partial pancreatectomy and partial hepatectomy) did glucagon levels return to normal. The therapeutic benefit caused by the analog in this syndrome differs from that in other endocrine tumor syndromes such as pancreatic cholera, carcinoid, or gastrinoma where circulating levels of tumor-produced agents are suppressed in conjunction with control of symptoms.</abstract><cop>Hagerstown, MD</cop><pub>Lippincott Williams & Wilkins</pub><pmid>2882503</pmid><doi>10.1097/00006676-198609000-00013</doi><tpages>6</tpages></addata></record> |
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| ispartof | Pancreas, 1986, Vol.1 (5), p.464-469 |
| issn | 0885-3177 1536-4828 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adult Antineoplastic Agents - therapeutic use Biological and medical sciences Dermatology Erythema - drug therapy Erythema - etiology Female Glucagon - blood Glucagonoma - complications Glucagonoma - drug therapy Glucagonoma - surgery Hormones. Endocrine system Humans Medical sciences Octreotide Pancreatic Neoplasms - complications Pancreatic Neoplasms - drug therapy Pancreatic Neoplasms - surgery Pharmacology. Drug treatments Somatostatin - analogs & derivatives Somatostatin - therapeutic use Tumors of the skin and soft tissue. Premalignant lesions |
| title | Somatostatin analog-induced remission of necrolytic migratory erythema without changes in plasma glucagon concentration |
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