Adipose tissue assessed by magnetic resonance imaging in growth hormone-deficient adults: the effect of growth hormone replacement and a comparison with control subjects
The visceral and subcutaneous abdominal adipose tissue (AT) area and the subcutaneous hip AT area were assessed by magnetic resonance imaging (MRI) in 12 growth hormone-deficient adults before and after 6 mo of replacement with recombinant human growth hormone (rhGH) and in 12 healthy control subjec...
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| Veröffentlicht in: | The American journal of clinical nutrition 1995-06, Vol.61 (6), p.1290-1294 |
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| container_title | The American journal of clinical nutrition |
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| creator | Snel, YE Brummer, RJ Doerga, ME Zelissen, PM Bakker, CJ Hendriks, MJ Koppeschaar, HP |
| description | The visceral and subcutaneous abdominal adipose tissue (AT) area and the subcutaneous hip AT area were assessed by magnetic resonance imaging (MRI) in 12 growth hormone-deficient adults before and after 6 mo of replacement with recombinant human growth hormone (rhGH) and in 12 healthy control subjects. The data obtained by MRI were compared with circumference measurements of waist and hip. Growth hormone-deficient patients compared with control subjects had a higher visceral AT area (P = 0.003) and subcutaneous AT area (P = 0.013); there was no significant difference in subcutaneous hip AT area. Six months of rhGH replacement reduced the subcutaneous hip AT area (19.8%), the subcutaneous abdominal AT area (15.6%), and particularly the visceral AT area (38.2%), resulting in fat areas that were not different from those of control subjects. Furthermore, this study shows that in contrast with control subjects, circumference measurements are not useful to predict AT areas in growth hormone-deficient patients and cannot be used to assess changes in AT areas during rhGH replacement. |
| doi_str_mv | 10.1093/ajcn/61.6.1290 |
| format | Article |
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The data obtained by MRI were compared with circumference measurements of waist and hip. Growth hormone-deficient patients compared with control subjects had a higher visceral AT area (P = 0.003) and subcutaneous AT area (P = 0.013); there was no significant difference in subcutaneous hip AT area. Six months of rhGH replacement reduced the subcutaneous hip AT area (19.8%), the subcutaneous abdominal AT area (15.6%), and particularly the visceral AT area (38.2%), resulting in fat areas that were not different from those of control subjects. Furthermore, this study shows that in contrast with control subjects, circumference measurements are not useful to predict AT areas in growth hormone-deficient patients and cannot be used to assess changes in AT areas during rhGH replacement.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/61.6.1290</identifier><identifier>PMID: 7762533</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Adipose Tissue - anatomy & histology ; Adipose Tissue - drug effects ; Adult ; Anatomy & physiology ; Anthropometry ; Biological and medical sciences ; Body Composition ; Body fat ; Double-Blind Method ; Female ; Growth Hormone - deficiency ; Growth Hormone - pharmacology ; Hormones ; Hormones. Endocrine system ; Humans ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Middle Aged ; NMR ; Nuclear magnetic resonance ; Pharmacology. Drug treatments</subject><ispartof>The American journal of clinical nutrition, 1995-06, Vol.61 (6), p.1290-1294</ispartof><rights>1995 American Society for Nutrition.</rights><rights>1995 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. 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The data obtained by MRI were compared with circumference measurements of waist and hip. Growth hormone-deficient patients compared with control subjects had a higher visceral AT area (P = 0.003) and subcutaneous AT area (P = 0.013); there was no significant difference in subcutaneous hip AT area. Six months of rhGH replacement reduced the subcutaneous hip AT area (19.8%), the subcutaneous abdominal AT area (15.6%), and particularly the visceral AT area (38.2%), resulting in fat areas that were not different from those of control subjects. Furthermore, this study shows that in contrast with control subjects, circumference measurements are not useful to predict AT areas in growth hormone-deficient patients and cannot be used to assess changes in AT areas during rhGH replacement.</description><subject>Adipose Tissue - anatomy & histology</subject><subject>Adipose Tissue - drug effects</subject><subject>Adult</subject><subject>Anatomy & physiology</subject><subject>Anthropometry</subject><subject>Biological and medical sciences</subject><subject>Body Composition</subject><subject>Body fat</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Growth Hormone - deficiency</subject><subject>Growth Hormone - pharmacology</subject><subject>Hormones</subject><subject>Hormones. Endocrine system</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Pharmacology. 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Endocrine system</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Pharmacology. 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The data obtained by MRI were compared with circumference measurements of waist and hip. Growth hormone-deficient patients compared with control subjects had a higher visceral AT area (P = 0.003) and subcutaneous AT area (P = 0.013); there was no significant difference in subcutaneous hip AT area. Six months of rhGH replacement reduced the subcutaneous hip AT area (19.8%), the subcutaneous abdominal AT area (15.6%), and particularly the visceral AT area (38.2%), resulting in fat areas that were not different from those of control subjects. Furthermore, this study shows that in contrast with control subjects, circumference measurements are not useful to predict AT areas in growth hormone-deficient patients and cannot be used to assess changes in AT areas during rhGH replacement.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>7762533</pmid><doi>10.1093/ajcn/61.6.1290</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| issn | 0002-9165 1938-3207 |
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| subjects | Adipose Tissue - anatomy & histology Adipose Tissue - drug effects Adult Anatomy & physiology Anthropometry Biological and medical sciences Body Composition Body fat Double-Blind Method Female Growth Hormone - deficiency Growth Hormone - pharmacology Hormones Hormones. Endocrine system Humans Magnetic Resonance Imaging Male Medical sciences Middle Aged NMR Nuclear magnetic resonance Pharmacology. Drug treatments |
| title | Adipose tissue assessed by magnetic resonance imaging in growth hormone-deficient adults: the effect of growth hormone replacement and a comparison with control subjects |
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