EFFECT OF CINNARIZINE ON IgE ANTIBODY MEDIATED ALLERGIC REACTION IN MICE AND RATS
The effect of cinnarizine on immunoglobulin E (IgE) antibody mediated allergic reactions in mice and rats was investigated. Nifedipine and tranilast were used as comparative drugs. 1) The dye leakage caused by IgE antibody mediated passive cutaneous anaphylaxis (PCA) in mouse ear was clearly inhibit...
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| Veröffentlicht in: | Journal of Pharmacobio-Dynamics 1986, Vol.9(11), pp.923-927 |
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| container_title | Journal of Pharmacobio-Dynamics |
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| creator | NAGAI, HIROICHI YAKUO, IKUHISA YAMADA, HIROAKI INAGAKI, NAOKI GOTO, SHOICHI KODA, AKIHIDE |
| description | The effect of cinnarizine on immunoglobulin E (IgE) antibody mediated allergic reactions in mice and rats was investigated. Nifedipine and tranilast were used as comparative drugs. 1) The dye leakage caused by IgE antibody mediated passive cutaneous anaphylaxis (PCA) in mouse ear was clearly inhibited by cinnarizine administered both orally and intraperitoneally. The inhibitory action of cinnarizine for PCA was as potent as nifedipine and superior to tranilast. 2) Cinnarizine clearly inhibited the increase in capillary permeability caused by histamine and calcium ionophore A 23187 (A 23187) but not by LTD4 in mouse ear. Nifedipine inhibited the increases of capillary permeability caused by A 23187, histamine and LTD4. Tranilast inhibited A 23187 induced vasculitis but not histamine or LTD4-induced reaction. 3) Cinnarizine had no significant effect on the release of histamine caused by antigen or A 23187 from rat peritoneal mast cells. Nifedipine and tranilast inhibited the release of histamine caused by both antigen and A 23187 from rat peritoneal mast cells. |
| doi_str_mv | 10.1248/bpb1978.9.923 |
| format | Article |
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Nifedipine and tranilast were used as comparative drugs. 1) The dye leakage caused by IgE antibody mediated passive cutaneous anaphylaxis (PCA) in mouse ear was clearly inhibited by cinnarizine administered both orally and intraperitoneally. The inhibitory action of cinnarizine for PCA was as potent as nifedipine and superior to tranilast. 2) Cinnarizine clearly inhibited the increase in capillary permeability caused by histamine and calcium ionophore A 23187 (A 23187) but not by LTD4 in mouse ear. Nifedipine inhibited the increases of capillary permeability caused by A 23187, histamine and LTD4. Tranilast inhibited A 23187 induced vasculitis but not histamine or LTD4-induced reaction. 3) Cinnarizine had no significant effect on the release of histamine caused by antigen or A 23187 from rat peritoneal mast cells. Nifedipine and tranilast inhibited the release of histamine caused by both antigen and A 23187 from rat peritoneal mast cells.</description><identifier>ISSN: 0386-846X</identifier><identifier>EISSN: 1881-1353</identifier><identifier>DOI: 10.1248/bpb1978.9.923</identifier><identifier>PMID: 2435883</identifier><identifier>CODEN: JOPHDQ</identifier><language>eng</language><publisher>Tokyo: The Pharmaceutical Society of Japan</publisher><subject>Animals ; Biological and medical sciences ; Calcimycin - antagonists & inhibitors ; Capillary Permeability - drug effects ; Cinnarizine - pharmacology ; Female ; Histamine Antagonists ; Histamine Release - drug effects ; IgE antibody ; Immunoglobulin E - physiology ; Male ; Mast Cells - immunology ; Medical sciences ; Mice ; Mice, Inbred BALB C ; Nifedipine - pharmacology ; ortho-Aminobenzoates - pharmacology ; Passive Cutaneous Anaphylaxis - drug effects ; Pharmacology. Drug treatments ; Rats ; Rats, Inbred Strains ; SRS-A - antagonists & inhibitors ; Urinary system</subject><ispartof>Journal of Pharmacobio-Dynamics, 1986, Vol.9(11), pp.923-927</ispartof><rights>The Pharmaceutical Society of Japan</rights><rights>1987 INIST-CNRS</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c612t-b5c9a2b36036dd3f00e10c076e6555a739ef09ba1c92c76f15be99c1018da6453</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1882,4023,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8382222$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2435883$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>NAGAI, HIROICHI</creatorcontrib><creatorcontrib>YAKUO, IKUHISA</creatorcontrib><creatorcontrib>YAMADA, HIROAKI</creatorcontrib><creatorcontrib>INAGAKI, NAOKI</creatorcontrib><creatorcontrib>GOTO, SHOICHI</creatorcontrib><creatorcontrib>KODA, AKIHIDE</creatorcontrib><title>EFFECT OF CINNARIZINE ON IgE ANTIBODY MEDIATED ALLERGIC REACTION IN MICE AND RATS</title><title>Journal of Pharmacobio-Dynamics</title><addtitle>Journal of Pharmacobio-Dynamics</addtitle><description>The effect of cinnarizine on immunoglobulin E (IgE) antibody mediated allergic reactions in mice and rats was investigated. Nifedipine and tranilast were used as comparative drugs. 1) The dye leakage caused by IgE antibody mediated passive cutaneous anaphylaxis (PCA) in mouse ear was clearly inhibited by cinnarizine administered both orally and intraperitoneally. The inhibitory action of cinnarizine for PCA was as potent as nifedipine and superior to tranilast. 2) Cinnarizine clearly inhibited the increase in capillary permeability caused by histamine and calcium ionophore A 23187 (A 23187) but not by LTD4 in mouse ear. Nifedipine inhibited the increases of capillary permeability caused by A 23187, histamine and LTD4. Tranilast inhibited A 23187 induced vasculitis but not histamine or LTD4-induced reaction. 3) Cinnarizine had no significant effect on the release of histamine caused by antigen or A 23187 from rat peritoneal mast cells. Nifedipine and tranilast inhibited the release of histamine caused by both antigen and A 23187 from rat peritoneal mast cells.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Calcimycin - antagonists & inhibitors</subject><subject>Capillary Permeability - drug effects</subject><subject>Cinnarizine - pharmacology</subject><subject>Female</subject><subject>Histamine Antagonists</subject><subject>Histamine Release - drug effects</subject><subject>IgE antibody</subject><subject>Immunoglobulin E - physiology</subject><subject>Male</subject><subject>Mast Cells - immunology</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Nifedipine - pharmacology</subject><subject>ortho-Aminobenzoates - pharmacology</subject><subject>Passive Cutaneous Anaphylaxis - drug effects</subject><subject>Pharmacology. Drug treatments</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>SRS-A - antagonists & inhibitors</subject><subject>Urinary system</subject><issn>0386-846X</issn><issn>1881-1353</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpN0M1LwzAYBvAgis7p0aOQg3jrzEeTJsfaZRqYHc4K6iWkWaqT7sNmO_jf27EyzCE5PL-8LzwAXGE0wCQWd-W6xDIRAzmQhB6BHhYCR5gyegx6iAoeiZi_nYHzEL4RiqVg-BSckpgyIWgPPKvRSGUFnIxgpvM8neoPnSs4yaH-VDDNC30_Gb7DJzXUaaGGMB2P1fRBZ3Cq0qzQO5fDJ53t7BBO0-LlApxUtg7-snv74HWkiuwxGk_af-k4chyTTVQyJy0pKUeUz2a0Qshj5FDCPWeM2YRKXyFZWuwkcQmvMCu9lA4jLGaWx4z2we1-7rpZ_Wx92JjFPDhf13bpV9tgkoTIBCWyhdEeumYVQuMrs27mC9v8GozMrkLTVWikaSts_XU3eFsu_Oygu87a_KbLbXC2rhq7dPNwYIIK0p6WZXv2HTb20x9y22zmrvb_lmLcXYQeUvdlG-OX9A9AtIhc</recordid><startdate>1986</startdate><enddate>1986</enddate><creator>NAGAI, HIROICHI</creator><creator>YAKUO, IKUHISA</creator><creator>YAMADA, HIROAKI</creator><creator>INAGAKI, NAOKI</creator><creator>GOTO, SHOICHI</creator><creator>KODA, AKIHIDE</creator><general>The Pharmaceutical Society of Japan</general><general>Pharmaceutical Society of Japan</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1986</creationdate><title>EFFECT OF CINNARIZINE ON IgE ANTIBODY MEDIATED ALLERGIC REACTION IN MICE AND RATS</title><author>NAGAI, HIROICHI ; YAKUO, IKUHISA ; YAMADA, HIROAKI ; INAGAKI, NAOKI ; GOTO, SHOICHI ; KODA, AKIHIDE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c612t-b5c9a2b36036dd3f00e10c076e6555a739ef09ba1c92c76f15be99c1018da6453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Calcimycin - antagonists & inhibitors</topic><topic>Capillary Permeability - drug effects</topic><topic>Cinnarizine - pharmacology</topic><topic>Female</topic><topic>Histamine Antagonists</topic><topic>Histamine Release - drug effects</topic><topic>IgE antibody</topic><topic>Immunoglobulin E - physiology</topic><topic>Male</topic><topic>Mast Cells - immunology</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Nifedipine - pharmacology</topic><topic>ortho-Aminobenzoates - pharmacology</topic><topic>Passive Cutaneous Anaphylaxis - drug effects</topic><topic>Pharmacology. Drug treatments</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>SRS-A - antagonists & inhibitors</topic><topic>Urinary system</topic><toplevel>online_resources</toplevel><creatorcontrib>NAGAI, HIROICHI</creatorcontrib><creatorcontrib>YAKUO, IKUHISA</creatorcontrib><creatorcontrib>YAMADA, HIROAKI</creatorcontrib><creatorcontrib>INAGAKI, NAOKI</creatorcontrib><creatorcontrib>GOTO, SHOICHI</creatorcontrib><creatorcontrib>KODA, AKIHIDE</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of Pharmacobio-Dynamics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NAGAI, HIROICHI</au><au>YAKUO, IKUHISA</au><au>YAMADA, HIROAKI</au><au>INAGAKI, NAOKI</au><au>GOTO, SHOICHI</au><au>KODA, AKIHIDE</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>EFFECT OF CINNARIZINE ON IgE ANTIBODY MEDIATED ALLERGIC REACTION IN MICE AND RATS</atitle><jtitle>Journal of Pharmacobio-Dynamics</jtitle><addtitle>Journal of Pharmacobio-Dynamics</addtitle><date>1986</date><risdate>1986</risdate><volume>9</volume><issue>11</issue><spage>923</spage><epage>927</epage><pages>923-927</pages><issn>0386-846X</issn><eissn>1881-1353</eissn><coden>JOPHDQ</coden><abstract>The effect of cinnarizine on immunoglobulin E (IgE) antibody mediated allergic reactions in mice and rats was investigated. Nifedipine and tranilast were used as comparative drugs. 1) The dye leakage caused by IgE antibody mediated passive cutaneous anaphylaxis (PCA) in mouse ear was clearly inhibited by cinnarizine administered both orally and intraperitoneally. The inhibitory action of cinnarizine for PCA was as potent as nifedipine and superior to tranilast. 2) Cinnarizine clearly inhibited the increase in capillary permeability caused by histamine and calcium ionophore A 23187 (A 23187) but not by LTD4 in mouse ear. Nifedipine inhibited the increases of capillary permeability caused by A 23187, histamine and LTD4. Tranilast inhibited A 23187 induced vasculitis but not histamine or LTD4-induced reaction. 3) Cinnarizine had no significant effect on the release of histamine caused by antigen or A 23187 from rat peritoneal mast cells. Nifedipine and tranilast inhibited the release of histamine caused by both antigen and A 23187 from rat peritoneal mast cells.</abstract><cop>Tokyo</cop><pub>The Pharmaceutical Society of Japan</pub><pmid>2435883</pmid><doi>10.1248/bpb1978.9.923</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of Pharmacobio-Dynamics, 1986, Vol.9(11), pp.923-927 |
| issn | 0386-846X 1881-1353 |
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| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Biological and medical sciences Calcimycin - antagonists & inhibitors Capillary Permeability - drug effects Cinnarizine - pharmacology Female Histamine Antagonists Histamine Release - drug effects IgE antibody Immunoglobulin E - physiology Male Mast Cells - immunology Medical sciences Mice Mice, Inbred BALB C Nifedipine - pharmacology ortho-Aminobenzoates - pharmacology Passive Cutaneous Anaphylaxis - drug effects Pharmacology. Drug treatments Rats Rats, Inbred Strains SRS-A - antagonists & inhibitors Urinary system |
| title | EFFECT OF CINNARIZINE ON IgE ANTIBODY MEDIATED ALLERGIC REACTION IN MICE AND RATS |
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