Anchoring of an Immunogenic Plasmodium falciparum Circumsporozoite Protein on the Surface of Dictyostelium discoideum(∗)

The circumsporozoite protein (CSP), a major antigen of Plasmodium falciparum, was expressed in the slime mold Dictyostelium discoideum. Fusion of the parasite protein to a leader peptide derived from Dictyostelium contact site A was essential for expression. The natural parasite surface antigen, how...

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Veröffentlicht in:	The Journal of biological chemistry 1995-05, Vol.270 (21), p.12941-12947
Hauptverfasser:	Reymond, Christophe D., Beghdadi-Rais, Carole, Roggero, Mario, Duarte, Elizabeth A., Desponds, Chantal, Bernard, Michel, Groux, Dorinne, Matile, Hugues, Bron, Claude, Corradin, Giampietro, Fasel, Nicolas J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Antibodies, Protozoan - biosynthesis Antigens, Protozoan - biosynthesis Antigens, Protozoan - genetics Antigens, Protozoan - immunology Dictyostelium - genetics Dictyostelium discoideum Gene Expression Genetic Vectors Glycosylphosphatidylinositols Immunization Membrane Proteins - biosynthesis Membrane Proteins - genetics Membrane Proteins - immunology Mice Mice, Inbred BALB C Molecular Sequence Data Plasmodium falciparum Plasmodium falciparum - genetics Plasmodium falciparum - immunology Protein Sorting Signals - genetics Protozoan Proteins - biosynthesis Protozoan Proteins - genetics Protozoan Proteins - immunology Protozoan Proteins - metabolism Recombinant Fusion Proteins - biosynthesis
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