Potent Ectopic Bone-Inducing Activity of Bone Morphogenetic Protein-4/7 Heterodimer

We have purified and characterized recombinant Xenopus bone morphogenetic proteins (xBMPs): homodimers of xBMP-4, 7 and heterodimers (xBMP-4/7) produced by a baculovirus expression system. Highly purified xBMPs had homogeneous NH2-termini predicted from a consensus motif, Arg-X-X-Arg, while they pos...

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Veröffentlicht in:	Biochemical and biophysical research communications 1995-05, Vol.210 (3), p.670-677
Hauptverfasser:	Aono, A., Hazama, M., Notoya, K., Taketomi, S., Yamasaki, H., Tsukuda, R., Sasaki, S., Fujisawa, Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaline Phosphatase - biosynthesis Amino Acid Sequence Animals Bone Development - drug effects Bone Marrow Cells Bone Morphogenetic Protein 7 Bone Morphogenetic Proteins Cell Differentiation - drug effects Cell Line Cells, Cultured Consensus Sequence Enzyme Induction Growth Substances - pharmacology Kinetics Male Molecular Sequence Data Osteoblasts - cytology Osteoblasts - drug effects Protein Biosynthesis Protein Multimerization Proteins - isolation & purification Proteins - pharmacology Rats Rats, Sprague-Dawley Recombinant Proteins - biosynthesis Recombinant Proteins - isolation & purification Recombinant Proteins - pharmacology Spodoptera Transfection Transforming Growth Factor beta Xenopus Xenopus Proteins
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