Octacosanol affects lipid metabolism in rats fed on a high-fat diet
The effect of dietary octacosanol, a long-chain alcohol, on lipid metabolism was investigated in rats fed on a high-fat diet for 20 d. The addition of octacosanol (10 g/kg diet) to the high-fat diet led to a significant reduction (P < 0·05) in the perirenal adipose tissue weight without decrease...
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| Veröffentlicht in: | British journal of nutrition 1995-03, Vol.73 (3), p.433-441 |
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| creator | Kato, S. Karino, K.-I. Hasegawa, S. Nagasawa, J. Nagasaki, A. Eguchi, M. Ichinose, T. Tago, K. Okumori, H. Hamatani, K. Takahashi, M. Ogasawara, J. Masushige, S. |
| description | The effect of dietary octacosanol, a long-chain alcohol, on lipid metabolism was investigated in rats fed on a high-fat diet for 20 d. The addition of octacosanol (10 g/kg diet) to the high-fat diet led to a significant reduction (P < 0·05) in the perirenal adipose tissue weight without decrease of the cell number, suggesting that octacosanol may suppress lipid accumulation in this tissue, whereas no effect was seen in the epididymal adipose tissue weight and in the lipid content in liver. Octacosanol supplementation decreased the serum triacylglycerol concentration, and enhanced the concentration of serum fatty acids, probably through inhibition of hepatic phosphatidate phosphohydrolase (EC 3·1·3·4). Though the activity of hormone-sensitive lipase (EC 3·1·1·3) was not influenced by octacosanol, higher activities of lipoprotein lipase (EC 3·1·1·34) in the perirenal adipose tissue and the total oxidation rate of fatty acid in muscle were observed. Lipid absorption was not affected by the inclusion of octacosanol. Thus, the present results suggest that the dietary incorporation of octacosanol into a high-fat diet affects some aspects of lipid metabolism. |
| doi_str_mv | 10.1079/BJN19950045 |
| format | Article |
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The addition of octacosanol (10 g/kg diet) to the high-fat diet led to a significant reduction (P < 0·05) in the perirenal adipose tissue weight without decrease of the cell number, suggesting that octacosanol may suppress lipid accumulation in this tissue, whereas no effect was seen in the epididymal adipose tissue weight and in the lipid content in liver. Octacosanol supplementation decreased the serum triacylglycerol concentration, and enhanced the concentration of serum fatty acids, probably through inhibition of hepatic phosphatidate phosphohydrolase (EC 3·1·3·4). Though the activity of hormone-sensitive lipase (EC 3·1·1·3) was not influenced by octacosanol, higher activities of lipoprotein lipase (EC 3·1·1·34) in the perirenal adipose tissue and the total oxidation rate of fatty acid in muscle were observed. Lipid absorption was not affected by the inclusion of octacosanol. Thus, the present results suggest that the dietary incorporation of octacosanol into a high-fat diet affects some aspects of lipid metabolism.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1079/BJN19950045</identifier><identifier>PMID: 7766566</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Adipose tissue ; Adipose Tissue - drug effects ; Adipose Tissue - metabolism ; Animals ; Dietary Fats - administration & dosage ; Effects of octacosanol on lipid metabolism ; Fatty Acids - blood ; Fatty Acids - metabolism ; Kidney ; Lipid Metabolism ; Lipoprotein Lipase - metabolism ; Male ; Octacosanol ; Octanols - pharmacology ; Oxidation-Reduction ; Rat ; Rats ; Rats, Wistar ; Serum triacylglycerol ; Triglycerides - blood</subject><ispartof>British journal of nutrition, 1995-03, Vol.73 (3), p.433-441</ispartof><rights>Copyright © The Nutrition Society 1995</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c505t-69b683a8ad821b0d6667d421e43934c8105f51b7b29003e3810cd0aac8a24d0f3</citedby><cites>FETCH-LOGICAL-c505t-69b683a8ad821b0d6667d421e43934c8105f51b7b29003e3810cd0aac8a24d0f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7766566$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kato, S.</creatorcontrib><creatorcontrib>Karino, K.-I.</creatorcontrib><creatorcontrib>Hasegawa, S.</creatorcontrib><creatorcontrib>Nagasawa, J.</creatorcontrib><creatorcontrib>Nagasaki, A.</creatorcontrib><creatorcontrib>Eguchi, M.</creatorcontrib><creatorcontrib>Ichinose, T.</creatorcontrib><creatorcontrib>Tago, K.</creatorcontrib><creatorcontrib>Okumori, H.</creatorcontrib><creatorcontrib>Hamatani, K.</creatorcontrib><creatorcontrib>Takahashi, M.</creatorcontrib><creatorcontrib>Ogasawara, J.</creatorcontrib><creatorcontrib>Masushige, S.</creatorcontrib><title>Octacosanol affects lipid metabolism in rats fed on a high-fat diet</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>The effect of dietary octacosanol, a long-chain alcohol, on lipid metabolism was investigated in rats fed on a high-fat diet for 20 d. The addition of octacosanol (10 g/kg diet) to the high-fat diet led to a significant reduction (P < 0·05) in the perirenal adipose tissue weight without decrease of the cell number, suggesting that octacosanol may suppress lipid accumulation in this tissue, whereas no effect was seen in the epididymal adipose tissue weight and in the lipid content in liver. Octacosanol supplementation decreased the serum triacylglycerol concentration, and enhanced the concentration of serum fatty acids, probably through inhibition of hepatic phosphatidate phosphohydrolase (EC 3·1·3·4). Though the activity of hormone-sensitive lipase (EC 3·1·1·3) was not influenced by octacosanol, higher activities of lipoprotein lipase (EC 3·1·1·34) in the perirenal adipose tissue and the total oxidation rate of fatty acid in muscle were observed. Lipid absorption was not affected by the inclusion of octacosanol. Thus, the present results suggest that the dietary incorporation of octacosanol into a high-fat diet affects some aspects of lipid metabolism.</description><subject>Adipose tissue</subject><subject>Adipose Tissue - drug effects</subject><subject>Adipose Tissue - metabolism</subject><subject>Animals</subject><subject>Dietary Fats - administration & dosage</subject><subject>Effects of octacosanol on lipid metabolism</subject><subject>Fatty Acids - blood</subject><subject>Fatty Acids - metabolism</subject><subject>Kidney</subject><subject>Lipid Metabolism</subject><subject>Lipoprotein Lipase - metabolism</subject><subject>Male</subject><subject>Octacosanol</subject><subject>Octanols - pharmacology</subject><subject>Oxidation-Reduction</subject><subject>Rat</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Serum triacylglycerol</subject><subject>Triglycerides - blood</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMtLxDAQh4Mo6_o4eRZy8iLVSZtHe9TFJ-KqKIKXME1SjfaxJl3Q_97KLurB0zDzfcwMP0J2GBwwUMXh8eU1KwoBwMUKGTOuRJJKma6SMQCohDEu1slGjK9DmzMoRmSklJRCyjGZTE2PpovYdjXFqnKmj7T2M29p43osu9rHhvqWBhxA5SztWor0xT-_JBX21HrXb5G1Cuvotpd1kzycntxPzpOr6dnF5OgqMQJEn8iilHmGOdo8ZSVYKaWyPGWOZ0XGzfCZqAQrVZkWAJnLhoGxgGhyTLmFKtske4u9s9C9z13sdeOjcXWNrevmUSuVFizP-SDuL0QTuhiDq_Qs-AbDp2agvyPTfyIb7N3l2nnZOPvjLjMaeLLgPvbu4wdjeNNSZUpoeXarHy-fbjicg7779Q02ZfD22enXbh7aIZp_738BjP-Bsg</recordid><startdate>19950301</startdate><enddate>19950301</enddate><creator>Kato, S.</creator><creator>Karino, K.-I.</creator><creator>Hasegawa, S.</creator><creator>Nagasawa, J.</creator><creator>Nagasaki, A.</creator><creator>Eguchi, M.</creator><creator>Ichinose, T.</creator><creator>Tago, K.</creator><creator>Okumori, H.</creator><creator>Hamatani, K.</creator><creator>Takahashi, M.</creator><creator>Ogasawara, J.</creator><creator>Masushige, S.</creator><general>Cambridge University Press</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950301</creationdate><title>Octacosanol affects lipid metabolism in rats fed on a high-fat diet</title><author>Kato, S. ; Karino, K.-I. ; Hasegawa, S. ; Nagasawa, J. ; Nagasaki, A. ; Eguchi, M. ; Ichinose, T. ; Tago, K. ; Okumori, H. ; Hamatani, K. ; Takahashi, M. ; Ogasawara, J. ; Masushige, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c505t-69b683a8ad821b0d6667d421e43934c8105f51b7b29003e3810cd0aac8a24d0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adipose tissue</topic><topic>Adipose Tissue - drug effects</topic><topic>Adipose Tissue - metabolism</topic><topic>Animals</topic><topic>Dietary Fats - administration & dosage</topic><topic>Effects of octacosanol on lipid metabolism</topic><topic>Fatty Acids - blood</topic><topic>Fatty Acids - metabolism</topic><topic>Kidney</topic><topic>Lipid Metabolism</topic><topic>Lipoprotein Lipase - metabolism</topic><topic>Male</topic><topic>Octacosanol</topic><topic>Octanols - pharmacology</topic><topic>Oxidation-Reduction</topic><topic>Rat</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Serum triacylglycerol</topic><topic>Triglycerides - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kato, S.</creatorcontrib><creatorcontrib>Karino, K.-I.</creatorcontrib><creatorcontrib>Hasegawa, S.</creatorcontrib><creatorcontrib>Nagasawa, J.</creatorcontrib><creatorcontrib>Nagasaki, A.</creatorcontrib><creatorcontrib>Eguchi, M.</creatorcontrib><creatorcontrib>Ichinose, T.</creatorcontrib><creatorcontrib>Tago, K.</creatorcontrib><creatorcontrib>Okumori, H.</creatorcontrib><creatorcontrib>Hamatani, K.</creatorcontrib><creatorcontrib>Takahashi, M.</creatorcontrib><creatorcontrib>Ogasawara, J.</creatorcontrib><creatorcontrib>Masushige, S.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kato, S.</au><au>Karino, K.-I.</au><au>Hasegawa, S.</au><au>Nagasawa, J.</au><au>Nagasaki, A.</au><au>Eguchi, M.</au><au>Ichinose, T.</au><au>Tago, K.</au><au>Okumori, H.</au><au>Hamatani, K.</au><au>Takahashi, M.</au><au>Ogasawara, J.</au><au>Masushige, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Octacosanol affects lipid metabolism in rats fed on a high-fat diet</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>1995-03-01</date><risdate>1995</risdate><volume>73</volume><issue>3</issue><spage>433</spage><epage>441</epage><pages>433-441</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><abstract>The effect of dietary octacosanol, a long-chain alcohol, on lipid metabolism was investigated in rats fed on a high-fat diet for 20 d. The addition of octacosanol (10 g/kg diet) to the high-fat diet led to a significant reduction (P < 0·05) in the perirenal adipose tissue weight without decrease of the cell number, suggesting that octacosanol may suppress lipid accumulation in this tissue, whereas no effect was seen in the epididymal adipose tissue weight and in the lipid content in liver. Octacosanol supplementation decreased the serum triacylglycerol concentration, and enhanced the concentration of serum fatty acids, probably through inhibition of hepatic phosphatidate phosphohydrolase (EC 3·1·3·4). Though the activity of hormone-sensitive lipase (EC 3·1·1·3) was not influenced by octacosanol, higher activities of lipoprotein lipase (EC 3·1·1·34) in the perirenal adipose tissue and the total oxidation rate of fatty acid in muscle were observed. Lipid absorption was not affected by the inclusion of octacosanol. Thus, the present results suggest that the dietary incorporation of octacosanol into a high-fat diet affects some aspects of lipid metabolism.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>7766566</pmid><doi>10.1079/BJN19950045</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of nutrition, 1995-03, Vol.73 (3), p.433-441 |
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| subjects | Adipose tissue Adipose Tissue - drug effects Adipose Tissue - metabolism Animals Dietary Fats - administration & dosage Effects of octacosanol on lipid metabolism Fatty Acids - blood Fatty Acids - metabolism Kidney Lipid Metabolism Lipoprotein Lipase - metabolism Male Octacosanol Octanols - pharmacology Oxidation-Reduction Rat Rats Rats, Wistar Serum triacylglycerol Triglycerides - blood |
| title | Octacosanol affects lipid metabolism in rats fed on a high-fat diet |
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