Immobilized human serum albumin: Liquid chromatography/mass spectrometry as a method of determining drug-protein binding

A liquid chromatography/mass spectrometry methodology is described that enables the simultaneous estimation of the individual protein‐binding affinities of a mixture of compounds. This approach has proved to be robust and enables a series of molecules to be ranked according to their protein‐binding...

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Veröffentlicht in:Rapid communications in mass spectrometry 1995, Vol.9 (4), p.261-263
Hauptverfasser: Tiller, Philip R., Mutton, Ian M., Lane, Stephen J., Bevan, Christopher D.
Format: Artikel
Sprache:eng
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Zusammenfassung:A liquid chromatography/mass spectrometry methodology is described that enables the simultaneous estimation of the individual protein‐binding affinities of a mixture of compounds. This approach has proved to be robust and enables a series of molecules to be ranked according to their protein‐binding affinities within 20 minutes.
ISSN:0951-4198
1097-0231
DOI:10.1002/rcm.1290090403