Immobilized human serum albumin: Liquid chromatography/mass spectrometry as a method of determining drug-protein binding
A liquid chromatography/mass spectrometry methodology is described that enables the simultaneous estimation of the individual protein‐binding affinities of a mixture of compounds. This approach has proved to be robust and enables a series of molecules to be ranked according to their protein‐binding...
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Veröffentlicht in: | Rapid communications in mass spectrometry 1995, Vol.9 (4), p.261-263 |
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Hauptverfasser: | , , , |
Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | A liquid chromatography/mass spectrometry methodology is described that enables the simultaneous estimation of the individual protein‐binding affinities of a mixture of compounds. This approach has proved to be robust and enables a series of molecules to be ranked according to their protein‐binding affinities within 20 minutes. |
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ISSN: | 0951-4198 1097-0231 |
DOI: | 10.1002/rcm.1290090403 |