Plasma Catecholamines and Neuropeptide-Y as Indices of Sympathetic Nerve Activity in Normotensive and Stroke-Prone Spontaneously Hypertensive Rats

The suitability of plasma catecholamines (CAs) and neuropeptide-Y (NPY) as biochemical indices of sympathetic nerve activity (SNA) has been investigated, and these parameters have been compared between adult normotensive (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP). Plasma norepine...

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Veröffentlicht in:Journal of cardiovascular pharmacology 1986-11, Vol.8 (6), p.1113-1121
Hauptverfasser: Howe, P R. C, Rogers, P F, Morris, M J, Chalmers, J P, Smith, R M
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container_end_page 1121
container_issue 6
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container_title Journal of cardiovascular pharmacology
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creator Howe, P R. C
Rogers, P F
Morris, M J
Chalmers, J P
Smith, R M
description The suitability of plasma catecholamines (CAs) and neuropeptide-Y (NPY) as biochemical indices of sympathetic nerve activity (SNA) has been investigated, and these parameters have been compared between adult normotensive (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP). Plasma norepinephrine (NE), epinephrine (E) and NPY were measured in venous and arterial blood samples taken from conscious, unrestrained rats. Under resting conditions, both CAs were significantly higher in SHRSP than in WKY; plasma E in particular was raised threefold. SHRSP had higher plasma levels of NPY in arterial blood but not in venous blood. Acute hydralazine-induced hypotension caused a slight rise in NPY and striking increases of CAs, which were accentuated in SHRSP. Ganglion blockade with pentolinium reversed these increases but the differences in basal plasma CA levels between strains still persisted. Barbiturate anaesthesia had little effect on plasma levels of NPY or NE, but plasma E levels were depressed, particularly in SHRSP, so that the strain difference in plasma E taken from venous blood was no longer apparent.
doi_str_mv 10.1097/00005344-198611000-00004
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Ganglion blockade with pentolinium reversed these increases but the differences in basal plasma CA levels between strains still persisted. 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Under resting conditions, both CAs were significantly higher in SHRSP than in WKY; plasma E in particular was raised threefold. SHRSP had higher plasma levels of NPY in arterial blood but not in venous blood. Acute hydralazine-induced hypotension caused a slight rise in NPY and striking increases of CAs, which were accentuated in SHRSP. Ganglion blockade with pentolinium reversed these increases but the differences in basal plasma CA levels between strains still persisted. Barbiturate anaesthesia had little effect on plasma levels of NPY or NE, but plasma E levels were depressed, particularly in SHRSP, so that the strain difference in plasma E taken from venous blood was no longer apparent.</description><subject>Anesthesia</subject><subject>Animals</subject><subject>Blood Pressure - drug effects</subject><subject>Catecholamines - blood</subject><subject>Hydralazine - pharmacology</subject><subject>Hypertension - blood</subject><subject>Male</subject><subject>Neuropeptide Y - blood</subject><subject>Rats</subject><subject>Rats, Inbred SHR</subject><subject>Rats, Inbred WKY</subject><subject>Species Specificity</subject><subject>Sympathetic Nervous System - physiology</subject><issn>0160-2446</issn><issn>1533-4023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1UU1v1DAQtSpQWUp_QiWfuAX8lTg-VitoK1WlYuHAyXKcidatEwfbaZW_wS8mYbe9MZfRzHvzZjQPIUzJJ0qU_EyWKLkQBVV1RelSFWtLnKANLTkvBGH8DdoQWpGCCVG9Q-9TeiCEilJWp-iUCS4kLzfoz703qTd4azLYffCmdwMkbIYW38EUwwhjdi0Uv7BJ-GZonV3Q0OHd3I8m7yE7uxDjE-BLm92TyzN2A74LsQ8ZhuQWYNXa5RgeobiPYQC8G8OQzQBhSn7G1_MI8YX73eT0Ab3tjE9wfsxn6OfXLz-218Xtt6ub7eVtYUtWiaIBW9ZAlWJckg5U3bQN6YhkzLSCUFN1ilDVmlZRCeuTmLKcCMsaSRupJD9DHw-6Ywy_J0hZ9y5Z8P5wmpaS1YoKsRDrA9HGkFKETo_R9SbOmhK92qFf7NCvdvxrraMXxx1T00P7Onj8_4KLA_4cfIaYHv30DFHvwfi81_9zmf8FtIOXaQ</recordid><startdate>198611</startdate><enddate>198611</enddate><creator>Howe, P R. 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C ; Rogers, P F ; Morris, M J ; Chalmers, J P ; Smith, R M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5264-bec58e1992370fe98bdb0f0722ad401a6f9019dad917e861129c304c2b71b7973</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Anesthesia</topic><topic>Animals</topic><topic>Blood Pressure - drug effects</topic><topic>Catecholamines - blood</topic><topic>Hydralazine - pharmacology</topic><topic>Hypertension - blood</topic><topic>Male</topic><topic>Neuropeptide Y - blood</topic><topic>Rats</topic><topic>Rats, Inbred SHR</topic><topic>Rats, Inbred WKY</topic><topic>Species Specificity</topic><topic>Sympathetic Nervous System - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Howe, P R. 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C</au><au>Rogers, P F</au><au>Morris, M J</au><au>Chalmers, J P</au><au>Smith, R M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Plasma Catecholamines and Neuropeptide-Y as Indices of Sympathetic Nerve Activity in Normotensive and Stroke-Prone Spontaneously Hypertensive Rats</atitle><jtitle>Journal of cardiovascular pharmacology</jtitle><addtitle>J Cardiovasc Pharmacol</addtitle><date>1986-11</date><risdate>1986</risdate><volume>8</volume><issue>6</issue><spage>1113</spage><epage>1121</epage><pages>1113-1121</pages><issn>0160-2446</issn><eissn>1533-4023</eissn><abstract>The suitability of plasma catecholamines (CAs) and neuropeptide-Y (NPY) as biochemical indices of sympathetic nerve activity (SNA) has been investigated, and these parameters have been compared between adult normotensive (WKY) and stroke-prone spontaneously hypertensive rats (SHRSP). Plasma norepinephrine (NE), epinephrine (E) and NPY were measured in venous and arterial blood samples taken from conscious, unrestrained rats. Under resting conditions, both CAs were significantly higher in SHRSP than in WKY; plasma E in particular was raised threefold. SHRSP had higher plasma levels of NPY in arterial blood but not in venous blood. Acute hydralazine-induced hypotension caused a slight rise in NPY and striking increases of CAs, which were accentuated in SHRSP. Ganglion blockade with pentolinium reversed these increases but the differences in basal plasma CA levels between strains still persisted. 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source MEDLINE; Journals@Ovid LWW Legacy Archive; Journals@Ovid Complete; EZB-FREE-00999 freely available EZB journals
subjects Anesthesia
Animals
Blood Pressure - drug effects
Catecholamines - blood
Hydralazine - pharmacology
Hypertension - blood
Male
Neuropeptide Y - blood
Rats
Rats, Inbred SHR
Rats, Inbred WKY
Species Specificity
Sympathetic Nervous System - physiology
title Plasma Catecholamines and Neuropeptide-Y as Indices of Sympathetic Nerve Activity in Normotensive and Stroke-Prone Spontaneously Hypertensive Rats
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