Cerebellar astrocytoma of childhood : long-term follow-up
Cerebellar astrocytoma of childhood has always been regarded as a benign tumour. Certain issues still attract debate, in particular the role of radiotherapy as an adjuvant to surgery, management of the cyst wall in cystic lesions and treatment of recurrent tumours. To provide some answers to these q...
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| Veröffentlicht in: | Child's nervous system 1995-02, Vol.11 (2), p.89-96 |
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| creator | SGOUROS, S FINERON, P. W HOCKLEY, A. D |
| description | Cerebellar astrocytoma of childhood has always been regarded as a benign tumour. Certain issues still attract debate, in particular the role of radiotherapy as an adjuvant to surgery, management of the cyst wall in cystic lesions and treatment of recurrent tumours. To provide some answers to these questions, the experience in Birmingham (United Kingdom) between the years 1959 and 1991 was reviewed. Ninety-seven patients aged 0-14 years had been treated and the histological material was reassessed independently. Detailed statistical and clinical analysis revealed that the main factor of negative prognostic value was the presence of brain stem involvement. In cystic tumours the surgical excision of the cyst wall did not offer significant advantage on survival. Similarly, postoperative radiotherapy did not improve survival, and there is a suggestion that it may actually predispose to malignant transformation. The implications on management are discussed. |
| doi_str_mv | 10.1007/BF00303812 |
| format | Article |
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Similarly, postoperative radiotherapy did not improve survival, and there is a suggestion that it may actually predispose to malignant transformation. 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W</creatorcontrib><creatorcontrib>HOCKLEY, A. D</creatorcontrib><title>Cerebellar astrocytoma of childhood : long-term follow-up</title><title>Child's nervous system</title><addtitle>Childs Nerv Syst</addtitle><description>Cerebellar astrocytoma of childhood has always been regarded as a benign tumour. Certain issues still attract debate, in particular the role of radiotherapy as an adjuvant to surgery, management of the cyst wall in cystic lesions and treatment of recurrent tumours. To provide some answers to these questions, the experience in Birmingham (United Kingdom) between the years 1959 and 1991 was reviewed. Ninety-seven patients aged 0-14 years had been treated and the histological material was reassessed independently. Detailed statistical and clinical analysis revealed that the main factor of negative prognostic value was the presence of brain stem involvement. In cystic tumours the surgical excision of the cyst wall did not offer significant advantage on survival. Similarly, postoperative radiotherapy did not improve survival, and there is a suggestion that it may actually predispose to malignant transformation. The implications on management are discussed.</description><subject>Adolescent</subject><subject>Astrocytoma - mortality</subject><subject>Astrocytoma - pathology</subject><subject>Astrocytoma - radiotherapy</subject><subject>Astrocytoma - surgery</subject><subject>Biological and medical sciences</subject><subject>Cerebellar Neoplasms - mortality</subject><subject>Cerebellar Neoplasms - pathology</subject><subject>Cerebellar Neoplasms - radiotherapy</subject><subject>Cerebellar Neoplasms - surgery</subject><subject>Cerebellum - pathology</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Combined Modality Therapy</subject><subject>Cranial Irradiation</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Neoplasm Recurrence, Local - mortality</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Recurrence, Local - radiotherapy</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>Neurologic Examination</subject><subject>Neurology</subject><subject>Reoperation</subject><subject>Retrospective Studies</subject><subject>Survival Rate</subject><subject>Tumors of the nervous system. Phacomatoses</subject><issn>0256-7040</issn><issn>1433-0350</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkEtLw0AUhQdRaq1u3AtZiAshemdunu60WBUKbnQdbuZhI5NOnUmQ_ntTGurqwjkfh8vH2CWHOw6Q3z8tABCw4OKITXmCGAOmcMymINIsziGBU3YWwjcATwtRTtgkz9MCeDFl5Vx7XWtryUcUOu_ktnMtRc5EctVYtXJORQ-RdeuvuNO-jYyz1v3G_eacnRiyQV-Md8Y-F88f89d4-f7yNn9cxhI572IllDCoBQGhlBmlucoM1SqhugTBhxCNKUhwJAWIBShJkCYyy2WplKxxxm72uxvvfnoduqptgtx9vNauD1Wei6IELAfwdg9K70Lw2lQb37TktxWHauep-vc0wFfjal-3Wh3QUczQX489BUnWeFrLJhwwTAB5kuIfMt9u2Q</recordid><startdate>19950201</startdate><enddate>19950201</enddate><creator>SGOUROS, S</creator><creator>FINERON, P. W</creator><creator>HOCKLEY, A. 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D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-d2d2f3e2a0a3cc6a57d6fabd4ab9021a3c3ff8a213ad03380dca054c67c9ddcb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adolescent</topic><topic>Astrocytoma - mortality</topic><topic>Astrocytoma - pathology</topic><topic>Astrocytoma - radiotherapy</topic><topic>Astrocytoma - surgery</topic><topic>Biological and medical sciences</topic><topic>Cerebellar Neoplasms - mortality</topic><topic>Cerebellar Neoplasms - pathology</topic><topic>Cerebellar Neoplasms - radiotherapy</topic><topic>Cerebellar Neoplasms - surgery</topic><topic>Cerebellum - pathology</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Combined Modality Therapy</topic><topic>Cranial Irradiation</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Neoplasm Recurrence, Local - mortality</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Recurrence, Local - radiotherapy</topic><topic>Neoplasm Recurrence, Local - surgery</topic><topic>Neurologic Examination</topic><topic>Neurology</topic><topic>Reoperation</topic><topic>Retrospective Studies</topic><topic>Survival Rate</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SGOUROS, S</creatorcontrib><creatorcontrib>FINERON, P. W</creatorcontrib><creatorcontrib>HOCKLEY, A. D</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Child's nervous system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SGOUROS, S</au><au>FINERON, P. W</au><au>HOCKLEY, A. D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cerebellar astrocytoma of childhood : long-term follow-up</atitle><jtitle>Child's nervous system</jtitle><addtitle>Childs Nerv Syst</addtitle><date>1995-02-01</date><risdate>1995</risdate><volume>11</volume><issue>2</issue><spage>89</spage><epage>96</epage><pages>89-96</pages><issn>0256-7040</issn><eissn>1433-0350</eissn><abstract>Cerebellar astrocytoma of childhood has always been regarded as a benign tumour. Certain issues still attract debate, in particular the role of radiotherapy as an adjuvant to surgery, management of the cyst wall in cystic lesions and treatment of recurrent tumours. To provide some answers to these questions, the experience in Birmingham (United Kingdom) between the years 1959 and 1991 was reviewed. Ninety-seven patients aged 0-14 years had been treated and the histological material was reassessed independently. Detailed statistical and clinical analysis revealed that the main factor of negative prognostic value was the presence of brain stem involvement. In cystic tumours the surgical excision of the cyst wall did not offer significant advantage on survival. Similarly, postoperative radiotherapy did not improve survival, and there is a suggestion that it may actually predispose to malignant transformation. The implications on management are discussed.</abstract><cop>Berlin</cop><pub>Springer</pub><pmid>7758018</pmid><doi>10.1007/BF00303812</doi><tpages>8</tpages></addata></record> |
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| issn | 0256-7040 1433-0350 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adolescent Astrocytoma - mortality Astrocytoma - pathology Astrocytoma - radiotherapy Astrocytoma - surgery Biological and medical sciences Cerebellar Neoplasms - mortality Cerebellar Neoplasms - pathology Cerebellar Neoplasms - radiotherapy Cerebellar Neoplasms - surgery Cerebellum - pathology Child Child, Preschool Combined Modality Therapy Cranial Irradiation Female Follow-Up Studies Humans Infant Male Medical sciences Neoplasm Recurrence, Local - mortality Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - radiotherapy Neoplasm Recurrence, Local - surgery Neurologic Examination Neurology Reoperation Retrospective Studies Survival Rate Tumors of the nervous system. Phacomatoses |
| title | Cerebellar astrocytoma of childhood : long-term follow-up |
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