Evidence for an association between CD23 and the receptor for a low molecular weight B cell growth factor
Low molecular weight B cell growth factor (BCGF) and a monoclonal antibody (MHM6) to the 45‐kDa, B lineage‐restricted, CD23 activation antigen (BLAST‐2; EBVCS) were found to be indistinguishable in their biological effects. Individually, both augmented DNA synthesis in activated, but not resting, B...
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| Veröffentlicht in: | European journal of immunology 1986-12, Vol.16 (12), p.1627-1630 |
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| container_issue | 12 |
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| container_title | European journal of immunology |
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| creator | Gordon, John Webb, Adrian J. Walker, Leonie Guy, Graeme R. Rowe, Martin |
| description | Low molecular weight B cell growth factor (BCGF) and a monoclonal antibody (MHM6) to the 45‐kDa, B lineage‐restricted, CD23 activation antigen (BLAST‐2; EBVCS) were found to be indistinguishable in their biological effects. Individually, both augmented DNA synthesis in activated, but not resting, B lymphocytes while no additional enhancement resulted from using the two agonists in combination. Furthermore, by increasing the expression of Tac, both MHM6 and BCGF promoted activated B cells to respond more vigorously to the late addition of recombinant interleukin 2. The presence of BCGF during B cell activations was found to down‐regulate the expression of the CD23 antigen while the coating of activated cells with MHM6 antibody diminished their capacity to absorb BCGF activity. The findings demonstrate that CD23 and a low molecular weight BCGF deliver a comparable growth‐promoting signal to activated B cells. A possible relationship between CD23 and the receptor for the low molecular weight BCGF is discussed. |
| doi_str_mv | 10.1002/eji.1830161225 |
| format | Article |
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Individually, both augmented DNA synthesis in activated, but not resting, B lymphocytes while no additional enhancement resulted from using the two agonists in combination. Furthermore, by increasing the expression of Tac, both MHM6 and BCGF promoted activated B cells to respond more vigorously to the late addition of recombinant interleukin 2. The presence of BCGF during B cell activations was found to down‐regulate the expression of the CD23 antigen while the coating of activated cells with MHM6 antibody diminished their capacity to absorb BCGF activity. The findings demonstrate that CD23 and a low molecular weight BCGF deliver a comparable growth‐promoting signal to activated B cells. A possible relationship between CD23 and the receptor for the low molecular weight BCGF is discussed.</description><identifier>ISSN: 0014-2980</identifier><identifier>EISSN: 1521-4141</identifier><identifier>DOI: 10.1002/eji.1830161225</identifier><identifier>PMID: 3028819</identifier><identifier>CODEN: EJIMAF</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH</publisher><subject>Analysis of the immune response. Humoral and cellular immunity ; Antibodies, Monoclonal - immunology ; Antigens, Surface - analysis ; B-Lymphocytes - drug effects ; Biological and medical sciences ; Cell Cycle ; Fundamental and applied biological sciences. Psychology ; Fundamental immunology ; Growth Substances - metabolism ; Growth Substances - pharmacology ; Humans ; Immunobiology ; Interleukin-2 ; Interleukin-4 ; Lymphocyte Activation ; Lymphokines - metabolism ; Lymphokines - pharmacology ; Molecular Weight ; Organs and cells involved in the immune response ; Receptors, Immunologic - analysis ; Receptors, Interleukin-2 ; Receptors, Interleukin-4 ; Receptors, Mitogen - analysis ; Receptors, Mitogen - drug effects ; Receptors, Mitogen - immunology ; Tumor Necrosis Factor Receptor Superfamily, Member 7</subject><ispartof>European journal of immunology, 1986-12, Vol.16 (12), p.1627-1630</ispartof><rights>Copyright © 1986 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3695-ac87ea68d6782b6e0e001b7dfc01db8ac769196e188be99b5a1f936dee77174b3</citedby><cites>FETCH-LOGICAL-c3695-ac87ea68d6782b6e0e001b7dfc01db8ac769196e188be99b5a1f936dee77174b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Feji.1830161225$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Feji.1830161225$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8288758$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3028819$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gordon, John</creatorcontrib><creatorcontrib>Webb, Adrian J.</creatorcontrib><creatorcontrib>Walker, Leonie</creatorcontrib><creatorcontrib>Guy, Graeme R.</creatorcontrib><creatorcontrib>Rowe, Martin</creatorcontrib><title>Evidence for an association between CD23 and the receptor for a low molecular weight B cell growth factor</title><title>European journal of immunology</title><addtitle>Eur J Immunol</addtitle><description>Low molecular weight B cell growth factor (BCGF) and a monoclonal antibody (MHM6) to the 45‐kDa, B lineage‐restricted, CD23 activation antigen (BLAST‐2; EBVCS) were found to be indistinguishable in their biological effects. Individually, both augmented DNA synthesis in activated, but not resting, B lymphocytes while no additional enhancement resulted from using the two agonists in combination. Furthermore, by increasing the expression of Tac, both MHM6 and BCGF promoted activated B cells to respond more vigorously to the late addition of recombinant interleukin 2. The presence of BCGF during B cell activations was found to down‐regulate the expression of the CD23 antigen while the coating of activated cells with MHM6 antibody diminished their capacity to absorb BCGF activity. The findings demonstrate that CD23 and a low molecular weight BCGF deliver a comparable growth‐promoting signal to activated B cells. A possible relationship between CD23 and the receptor for the low molecular weight BCGF is discussed.</description><subject>Analysis of the immune response. Humoral and cellular immunity</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antigens, Surface - analysis</subject><subject>B-Lymphocytes - drug effects</subject><subject>Biological and medical sciences</subject><subject>Cell Cycle</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Fundamental immunology</subject><subject>Growth Substances - metabolism</subject><subject>Growth Substances - pharmacology</subject><subject>Humans</subject><subject>Immunobiology</subject><subject>Interleukin-2</subject><subject>Interleukin-4</subject><subject>Lymphocyte Activation</subject><subject>Lymphokines - metabolism</subject><subject>Lymphokines - pharmacology</subject><subject>Molecular Weight</subject><subject>Organs and cells involved in the immune response</subject><subject>Receptors, Immunologic - analysis</subject><subject>Receptors, Interleukin-2</subject><subject>Receptors, Interleukin-4</subject><subject>Receptors, Mitogen - analysis</subject><subject>Receptors, Mitogen - drug effects</subject><subject>Receptors, Mitogen - immunology</subject><subject>Tumor Necrosis Factor Receptor Superfamily, Member 7</subject><issn>0014-2980</issn><issn>1521-4141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL1v2zAQxYkiheO4XbsF4BBkk8ujLH6MieO0KQx0aWeBok42DVl0SDmC__vSteFm63TD-929d4-QL8CmwBj_ihs3BZUzEMB58YGMoeCQzWAGV2TMGMwyrhW7JjcxbhhjWhR6REY540qBHhO3eHM1dhZp4wM1HTUxeutM73xHK-wHxI7On3ietJr2a6QBLe76BP9doK0f6Na3aPetCXRAt1r39JFabFu6Cn7o17QxNvGfyMfGtBE_n-eE_H5e_Jp_z5Y_v73MH5aZzYUuMmOVRCNULaTilUCG6YlK1o1lUFfKWCk0aIGgVIVaV4WBRueiRpQS5KzKJ-T-dHcX_OseY19uXTzGMR36fSyl5ErkXCVwegJt8DEGbMpdcFsTDiWw8thtmbot_3WbFm7Pl_fVFusLfi4z6Xdn3URr2iaYzrp4wVSiZHH01SdscC0e_mNaLn68vIvwB9owkgA</recordid><startdate>19861201</startdate><enddate>19861201</enddate><creator>Gordon, John</creator><creator>Webb, Adrian J.</creator><creator>Walker, Leonie</creator><creator>Guy, Graeme R.</creator><creator>Rowe, Martin</creator><general>WILEY‐VCH Verlag GmbH</general><general>Wiley-VCH</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19861201</creationdate><title>Evidence for an association between CD23 and the receptor for a low molecular weight B cell growth factor</title><author>Gordon, John ; Webb, Adrian J. ; Walker, Leonie ; Guy, Graeme R. ; Rowe, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3695-ac87ea68d6782b6e0e001b7dfc01db8ac769196e188be99b5a1f936dee77174b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>Analysis of the immune response. Humoral and cellular immunity</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antigens, Surface - analysis</topic><topic>B-Lymphocytes - drug effects</topic><topic>Biological and medical sciences</topic><topic>Cell Cycle</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Growth Substances - metabolism</topic><topic>Growth Substances - pharmacology</topic><topic>Humans</topic><topic>Immunobiology</topic><topic>Interleukin-2</topic><topic>Interleukin-4</topic><topic>Lymphocyte Activation</topic><topic>Lymphokines - metabolism</topic><topic>Lymphokines - pharmacology</topic><topic>Molecular Weight</topic><topic>Organs and cells involved in the immune response</topic><topic>Receptors, Immunologic - analysis</topic><topic>Receptors, Interleukin-2</topic><topic>Receptors, Interleukin-4</topic><topic>Receptors, Mitogen - analysis</topic><topic>Receptors, Mitogen - drug effects</topic><topic>Receptors, Mitogen - immunology</topic><topic>Tumor Necrosis Factor Receptor Superfamily, Member 7</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gordon, John</creatorcontrib><creatorcontrib>Webb, Adrian J.</creatorcontrib><creatorcontrib>Walker, Leonie</creatorcontrib><creatorcontrib>Guy, Graeme R.</creatorcontrib><creatorcontrib>Rowe, Martin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gordon, John</au><au>Webb, Adrian J.</au><au>Walker, Leonie</au><au>Guy, Graeme R.</au><au>Rowe, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evidence for an association between CD23 and the receptor for a low molecular weight B cell growth factor</atitle><jtitle>European journal of immunology</jtitle><addtitle>Eur J Immunol</addtitle><date>1986-12-01</date><risdate>1986</risdate><volume>16</volume><issue>12</issue><spage>1627</spage><epage>1630</epage><pages>1627-1630</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><coden>EJIMAF</coden><abstract>Low molecular weight B cell growth factor (BCGF) and a monoclonal antibody (MHM6) to the 45‐kDa, B lineage‐restricted, CD23 activation antigen (BLAST‐2; EBVCS) were found to be indistinguishable in their biological effects. Individually, both augmented DNA synthesis in activated, but not resting, B lymphocytes while no additional enhancement resulted from using the two agonists in combination. Furthermore, by increasing the expression of Tac, both MHM6 and BCGF promoted activated B cells to respond more vigorously to the late addition of recombinant interleukin 2. The presence of BCGF during B cell activations was found to down‐regulate the expression of the CD23 antigen while the coating of activated cells with MHM6 antibody diminished their capacity to absorb BCGF activity. The findings demonstrate that CD23 and a low molecular weight BCGF deliver a comparable growth‐promoting signal to activated B cells. A possible relationship between CD23 and the receptor for the low molecular weight BCGF is discussed.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH</pub><pmid>3028819</pmid><doi>10.1002/eji.1830161225</doi><tpages>4</tpages></addata></record> |
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| issn | 0014-2980 1521-4141 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Analysis of the immune response. Humoral and cellular immunity Antibodies, Monoclonal - immunology Antigens, Surface - analysis B-Lymphocytes - drug effects Biological and medical sciences Cell Cycle Fundamental and applied biological sciences. Psychology Fundamental immunology Growth Substances - metabolism Growth Substances - pharmacology Humans Immunobiology Interleukin-2 Interleukin-4 Lymphocyte Activation Lymphokines - metabolism Lymphokines - pharmacology Molecular Weight Organs and cells involved in the immune response Receptors, Immunologic - analysis Receptors, Interleukin-2 Receptors, Interleukin-4 Receptors, Mitogen - analysis Receptors, Mitogen - drug effects Receptors, Mitogen - immunology Tumor Necrosis Factor Receptor Superfamily, Member 7 |
| title | Evidence for an association between CD23 and the receptor for a low molecular weight B cell growth factor |
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