Cloning and comparative sequence analysis of the gene encoding canine intercellular adhesion molecule-1 (ICAM-1)
Canine intercellular adhesion molecule-1 (ICAM-1) plays a primary role in the adherence of canine neutrophils to endothelial cells and in the cytotoxicity of canine neutrophils for adult cardiac myocytes. We have cloned the canine ICAM-1 gene and have analyzed the conservation of ICAM-1 amino acid (...
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| Veröffentlicht in: | Gene 1995-04, Vol.156 (2), p.291-295 |
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| creator | Manning, Anthony M. Lu, Hui-Fang Kukielka, Gilbert L. Oliver, Mary G. Ty, Theresa Toman, Carol A. Drong, Roger F. Slightom, Jerry L. Ballantyne, Christie M. Entman, Mark L. Smith, C.Wayne Anderson, Donald C. |
| description | Canine intercellular adhesion molecule-1 (ICAM-1) plays a primary role in the adherence of canine neutrophils to endothelial cells and in the cytotoxicity of canine neutrophils for adult cardiac myocytes. We have cloned the canine
ICAM-1 gene and have analyzed the conservation of ICAM-1 amino acid (aa) sequences in man, chimpanzee, mouse, rat and dog. Canine ICAM-1 displays 61% identity with human ICAM-1. Cys residues critical to the immunoglobulin (Ig) fold structure and four sites of
N-linked glycosylation are absolutely conserved in ICAM-1 from all species. Residues in the cytoplasmic tail associated with cytoskeletal α-actinin binding are highly conserved, supporting the hypothesis that intracellular attachment is indeed important for ICAM-1 function. Residues critical for human ICAM-1 binding to the β
2-integrin leukocyte-function-associated antigen 1 (LFA-1) are highly conserved between all species, whereas those residues demonstrated to play an important role in interaction of human ICAM-1 with macrophage activation complex 1 (Mac-1) are not highly conserved. Residues critical for ICAM-1 binding to rhinovirus and malaria-infected red blood cells (IRBC) are not highly conserved. |
| doi_str_mv | 10.1016/0378-1119(95)00045-8 |
| format | Article |
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ICAM-1 gene and have analyzed the conservation of ICAM-1 amino acid (aa) sequences in man, chimpanzee, mouse, rat and dog. Canine ICAM-1 displays 61% identity with human ICAM-1. Cys residues critical to the immunoglobulin (Ig) fold structure and four sites of
N-linked glycosylation are absolutely conserved in ICAM-1 from all species. Residues in the cytoplasmic tail associated with cytoskeletal α-actinin binding are highly conserved, supporting the hypothesis that intracellular attachment is indeed important for ICAM-1 function. Residues critical for human ICAM-1 binding to the β
2-integrin leukocyte-function-associated antigen 1 (LFA-1) are highly conserved between all species, whereas those residues demonstrated to play an important role in interaction of human ICAM-1 with macrophage activation complex 1 (Mac-1) are not highly conserved. Residues critical for ICAM-1 binding to rhinovirus and malaria-infected red blood cells (IRBC) are not highly conserved.</description><identifier>ISSN: 0378-1119</identifier><identifier>EISSN: 1879-0038</identifier><identifier>DOI: 10.1016/0378-1119(95)00045-8</identifier><identifier>PMID: 7758971</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Amino Acid Sequence ; Animals ; Base Sequence ; Binding Sites ; Conserved Sequence ; DNA, Complementary - genetics ; dog ; Dogs ; Endothelium, Vascular - cytology ; Erythrocytes - parasitology ; Erythrocytes - virology ; Gene Library ; Humans ; immunoglobulin supergene family ; inflammation ; Intercellular Adhesion Molecule-1 - genetics ; Lymphocyte Function-Associated Antigen-1 - metabolism ; Macrophage-1 Antigen - metabolism ; Malaria - immunology ; Molecular Sequence Data ; Neutrophil ; Picornaviridae Infections - immunology ; Protein Binding ; Rhinovirus - immunology ; Sequence Analysis, DNA ; Sequence Homology, Amino Acid ; Species Specificity</subject><ispartof>Gene, 1995-04, Vol.156 (2), p.291-295</ispartof><rights>1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c454t-6dffe7595ea854b598647081e683aae3d66da13998e97370503e631bbf58aefb3</citedby><cites>FETCH-LOGICAL-c454t-6dffe7595ea854b598647081e683aae3d66da13998e97370503e631bbf58aefb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0378-1119(95)00045-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7758971$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Manning, Anthony M.</creatorcontrib><creatorcontrib>Lu, Hui-Fang</creatorcontrib><creatorcontrib>Kukielka, Gilbert L.</creatorcontrib><creatorcontrib>Oliver, Mary G.</creatorcontrib><creatorcontrib>Ty, Theresa</creatorcontrib><creatorcontrib>Toman, Carol A.</creatorcontrib><creatorcontrib>Drong, Roger F.</creatorcontrib><creatorcontrib>Slightom, Jerry L.</creatorcontrib><creatorcontrib>Ballantyne, Christie M.</creatorcontrib><creatorcontrib>Entman, Mark L.</creatorcontrib><creatorcontrib>Smith, C.Wayne</creatorcontrib><creatorcontrib>Anderson, Donald C.</creatorcontrib><title>Cloning and comparative sequence analysis of the gene encoding canine intercellular adhesion molecule-1 (ICAM-1)</title><title>Gene</title><addtitle>Gene</addtitle><description>Canine intercellular adhesion molecule-1 (ICAM-1) plays a primary role in the adherence of canine neutrophils to endothelial cells and in the cytotoxicity of canine neutrophils for adult cardiac myocytes. We have cloned the canine
ICAM-1 gene and have analyzed the conservation of ICAM-1 amino acid (aa) sequences in man, chimpanzee, mouse, rat and dog. Canine ICAM-1 displays 61% identity with human ICAM-1. Cys residues critical to the immunoglobulin (Ig) fold structure and four sites of
N-linked glycosylation are absolutely conserved in ICAM-1 from all species. Residues in the cytoplasmic tail associated with cytoskeletal α-actinin binding are highly conserved, supporting the hypothesis that intracellular attachment is indeed important for ICAM-1 function. Residues critical for human ICAM-1 binding to the β
2-integrin leukocyte-function-associated antigen 1 (LFA-1) are highly conserved between all species, whereas those residues demonstrated to play an important role in interaction of human ICAM-1 with macrophage activation complex 1 (Mac-1) are not highly conserved. Residues critical for ICAM-1 binding to rhinovirus and malaria-infected red blood cells (IRBC) are not highly conserved.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>Base Sequence</subject><subject>Binding Sites</subject><subject>Conserved Sequence</subject><subject>DNA, Complementary - genetics</subject><subject>dog</subject><subject>Dogs</subject><subject>Endothelium, Vascular - cytology</subject><subject>Erythrocytes - parasitology</subject><subject>Erythrocytes - virology</subject><subject>Gene Library</subject><subject>Humans</subject><subject>immunoglobulin supergene family</subject><subject>inflammation</subject><subject>Intercellular Adhesion Molecule-1 - genetics</subject><subject>Lymphocyte Function-Associated Antigen-1 - metabolism</subject><subject>Macrophage-1 Antigen - metabolism</subject><subject>Malaria - immunology</subject><subject>Molecular Sequence Data</subject><subject>Neutrophil</subject><subject>Picornaviridae Infections - immunology</subject><subject>Protein Binding</subject><subject>Rhinovirus - immunology</subject><subject>Sequence Analysis, DNA</subject><subject>Sequence Homology, Amino Acid</subject><subject>Species Specificity</subject><issn>0378-1119</issn><issn>1879-0038</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkUtPxCAUhYnR6Pj4B5qwMuOiCkMpsDExE1-Jxo2uCYVbxbRlhNbEfy91Ji51xeJ8517uOQgdU3JOCa0uCBOyoJSqueJnhJCSF3ILzagUqiCEyW00-0X20H5K7xkinC920a4QXCpBZ2i1bEPv-1dseodt6FYmmsF_Ak7wMUJvIQum_Uo-4dDg4Q3wK_SAsxLcZLMmuwH7foBooW3H1kRs3BskH3rchRbs2EJB8fx-efVY0LNDtNOYNsHR5j1ALzfXz8u74uHpNiMPhS15ORSVaxoQXHEwkpc1V7IqBZEUKsmMAeaqyhnKlJKgBBOEEwYVo3XdcGmgqdkBOl3PXcWQL0mD7nyafmh6CGPSQixkqZT6F6SVLAmniwyWa9DGkFKERq-i70z80pToqRE9xa2nuLXi-qcRLbPtZDN_rDtwv6ZNBVm_XOuQ0_j0EHWyfkre-Qh20C74vxd8A1FdmjY</recordid><startdate>19950424</startdate><enddate>19950424</enddate><creator>Manning, Anthony M.</creator><creator>Lu, Hui-Fang</creator><creator>Kukielka, Gilbert L.</creator><creator>Oliver, Mary G.</creator><creator>Ty, Theresa</creator><creator>Toman, Carol A.</creator><creator>Drong, Roger F.</creator><creator>Slightom, Jerry L.</creator><creator>Ballantyne, Christie M.</creator><creator>Entman, Mark L.</creator><creator>Smith, C.Wayne</creator><creator>Anderson, Donald C.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>19950424</creationdate><title>Cloning and comparative sequence analysis of the gene encoding canine intercellular adhesion molecule-1 (ICAM-1)</title><author>Manning, Anthony M. ; Lu, Hui-Fang ; Kukielka, Gilbert L. ; Oliver, Mary G. ; Ty, Theresa ; Toman, Carol A. ; Drong, Roger F. ; Slightom, Jerry L. ; Ballantyne, Christie M. ; Entman, Mark L. ; Smith, C.Wayne ; Anderson, Donald C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c454t-6dffe7595ea854b598647081e683aae3d66da13998e97370503e631bbf58aefb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>Base Sequence</topic><topic>Binding Sites</topic><topic>Conserved Sequence</topic><topic>DNA, Complementary - genetics</topic><topic>dog</topic><topic>Dogs</topic><topic>Endothelium, Vascular - cytology</topic><topic>Erythrocytes - parasitology</topic><topic>Erythrocytes - virology</topic><topic>Gene Library</topic><topic>Humans</topic><topic>immunoglobulin supergene family</topic><topic>inflammation</topic><topic>Intercellular Adhesion Molecule-1 - genetics</topic><topic>Lymphocyte Function-Associated Antigen-1 - metabolism</topic><topic>Macrophage-1 Antigen - metabolism</topic><topic>Malaria - immunology</topic><topic>Molecular Sequence Data</topic><topic>Neutrophil</topic><topic>Picornaviridae Infections - immunology</topic><topic>Protein Binding</topic><topic>Rhinovirus - immunology</topic><topic>Sequence Analysis, DNA</topic><topic>Sequence Homology, Amino Acid</topic><topic>Species Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Manning, Anthony M.</creatorcontrib><creatorcontrib>Lu, Hui-Fang</creatorcontrib><creatorcontrib>Kukielka, Gilbert L.</creatorcontrib><creatorcontrib>Oliver, Mary G.</creatorcontrib><creatorcontrib>Ty, Theresa</creatorcontrib><creatorcontrib>Toman, Carol A.</creatorcontrib><creatorcontrib>Drong, Roger F.</creatorcontrib><creatorcontrib>Slightom, Jerry L.</creatorcontrib><creatorcontrib>Ballantyne, Christie M.</creatorcontrib><creatorcontrib>Entman, Mark L.</creatorcontrib><creatorcontrib>Smith, C.Wayne</creatorcontrib><creatorcontrib>Anderson, Donald C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Gene</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Manning, Anthony M.</au><au>Lu, Hui-Fang</au><au>Kukielka, Gilbert L.</au><au>Oliver, Mary G.</au><au>Ty, Theresa</au><au>Toman, Carol A.</au><au>Drong, Roger F.</au><au>Slightom, Jerry L.</au><au>Ballantyne, Christie M.</au><au>Entman, Mark L.</au><au>Smith, C.Wayne</au><au>Anderson, Donald C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cloning and comparative sequence analysis of the gene encoding canine intercellular adhesion molecule-1 (ICAM-1)</atitle><jtitle>Gene</jtitle><addtitle>Gene</addtitle><date>1995-04-24</date><risdate>1995</risdate><volume>156</volume><issue>2</issue><spage>291</spage><epage>295</epage><pages>291-295</pages><issn>0378-1119</issn><eissn>1879-0038</eissn><abstract>Canine intercellular adhesion molecule-1 (ICAM-1) plays a primary role in the adherence of canine neutrophils to endothelial cells and in the cytotoxicity of canine neutrophils for adult cardiac myocytes. We have cloned the canine
ICAM-1 gene and have analyzed the conservation of ICAM-1 amino acid (aa) sequences in man, chimpanzee, mouse, rat and dog. Canine ICAM-1 displays 61% identity with human ICAM-1. Cys residues critical to the immunoglobulin (Ig) fold structure and four sites of
N-linked glycosylation are absolutely conserved in ICAM-1 from all species. Residues in the cytoplasmic tail associated with cytoskeletal α-actinin binding are highly conserved, supporting the hypothesis that intracellular attachment is indeed important for ICAM-1 function. Residues critical for human ICAM-1 binding to the β
2-integrin leukocyte-function-associated antigen 1 (LFA-1) are highly conserved between all species, whereas those residues demonstrated to play an important role in interaction of human ICAM-1 with macrophage activation complex 1 (Mac-1) are not highly conserved. Residues critical for ICAM-1 binding to rhinovirus and malaria-infected red blood cells (IRBC) are not highly conserved.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>7758971</pmid><doi>10.1016/0378-1119(95)00045-8</doi><tpages>5</tpages></addata></record> |
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| ispartof | Gene, 1995-04, Vol.156 (2), p.291-295 |
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| subjects | Amino Acid Sequence Animals Base Sequence Binding Sites Conserved Sequence DNA, Complementary - genetics dog Dogs Endothelium, Vascular - cytology Erythrocytes - parasitology Erythrocytes - virology Gene Library Humans immunoglobulin supergene family inflammation Intercellular Adhesion Molecule-1 - genetics Lymphocyte Function-Associated Antigen-1 - metabolism Macrophage-1 Antigen - metabolism Malaria - immunology Molecular Sequence Data Neutrophil Picornaviridae Infections - immunology Protein Binding Rhinovirus - immunology Sequence Analysis, DNA Sequence Homology, Amino Acid Species Specificity |
| title | Cloning and comparative sequence analysis of the gene encoding canine intercellular adhesion molecule-1 (ICAM-1) |
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