Comparative aspects of cerebellar [ 3H]flunitrazepam and [ 3H]GABA binding

1. 1. [ 3H]Flu and [ 3H]GABA binding has been studied in mice and Rabbit cerebellum (Ce). 2. 2. The B max of [ 3H]Flu binding in Ce membranes is similar in all mice strains examined and Rabbit. However, in Ce homogenate there are significant differences in both k d and B max. 3. 3. Subcellular distr...

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Veröffentlicht in:	General pharmacology 1986, Vol.17 (6), p.689-693
Hauptverfasser:	Matsokis, Nikolaos, Dalezios, Yannis
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Binding Sites Cerebellum - metabolism Flunitrazepam - metabolism gamma-Aminobutyric Acid - metabolism Kinetics Male Mice Mice, Inbred Strains Nerve Tissue Proteins - metabolism Rabbits Species Specificity Synaptic Membranes - metabolism Synaptosomes - metabolism
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Zusammenfassung:	1. 1. [ 3H]Flu and [ 3H]GABA binding has been studied in mice and Rabbit cerebellum (Ce). 2. 2. The B max of [ 3H]Flu binding in Ce membranes is similar in all mice strains examined and Rabbit. However, in Ce homogenate there are significant differences in both k d and B max. 3. 3. Subcellular distribution shows higher [ 3H]Flu binding in the nuclear than in the membranous fraction. However, the [ 3H]GABA binding is lower in the nuclear than the membranous fraction.
ISSN:	0306-3623 1879-0011
DOI:	10.1016/0306-3623(86)90301-0