Vitamin E inhibits the intimal response to balloon catheter injury in the carotid artery of the cholesterol-fed rat

We have investigated the effect of the naturally occurring, lipid-soluble antioxidant, vitamin E, on the intimal response to balloon injury in the cholesterol-fed rat. We found that in animals receiving a 0.5% vitamin E plus 1% cholesterol diet, neo-intimal thickening was reduced by 30% ( P < 0.0...

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Veröffentlicht in:	Atherosclerosis 1995-02, Vol.113 (1), p.29-39
Hauptverfasser:	Konneh, Matthew K., Rutherford, Claire, Li, Shu-Rui, Änggård, Erik E., Ferns, Gordon A.A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance animal injuries Animals Aorta, Thoracic - cytology arteries Atherosclerosis (general aspects, experimental research) Balloon catheter Biological and medical sciences Blood and lymphatic vessels blood plasma blood serum Cardiology. Vascular system Carotid Arteries - drug effects Carotid Arteries - pathology Carotid artery Carotid Artery Injuries Catheterization - adverse effects catheters cell division Cell Division - drug effects cells Cells, Cultured cholesterol Cholesterol, Dietary - administration & dosage Cholesterol-feeding diet experimental diets in vitro inhibition linings macrophages Macrophages - pathology Male Medical sciences mitogenesis mitogens monocytes Monocytes - pathology Muscle, Smooth, Vascular - cytology Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - pathology nutrient-nutrient interactions platelet-derived growth factor Platelet-Derived Growth Factor - pharmacology Rat Rats Rats, Wistar Reactive oxygen species Regression Analysis responses smooth muscle thickness Tunica Intima - drug effects Tunica Intima - injuries Tunica Intima - pathology vitamin E Vitamin E - pharmacology vitamin supplements Wounds and Injuries - prevention & control
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Zusammenfassung:	We have investigated the effect of the naturally occurring, lipid-soluble antioxidant, vitamin E, on the intimal response to balloon injury in the cholesterol-fed rat. We found that in animals receiving a 0.5% vitamin E plus 1% cholesterol diet, neo-intimal thickening was reduced by 30% ( P < 0.025) compared to animals receiving either cholesterol alone, or a control chow diet. In all three dietary groups, the intimal lesion consisted predominantly of smooth muscle cells, and few monocytes/macrophages (
ISSN:	0021-9150 1879-1484
DOI:	10.1016/0021-9150(94)05423-G