OF4949, NEW INHIBITORS OF AMINOPEPTIDASE B: III. BIOSYNTHESIS
To elevate production of OF4949 byPeuicillium rugulosum OF4949 and to elucidate the pathway of its biosynthesis, mutants were selected on the basis of their resistance to growth inhibition by phenylalanine analogs. A mutant resistant tom-fluorophenylalanine, strain No. M414, had 3-fold the productio...
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| Veröffentlicht in: | Journal of antibiotics 1986, Vol.39(12), pp.1697-1703 |
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| container_issue | 12 |
| container_start_page | 1697 |
| container_title | Journal of antibiotics |
| container_volume | 39 |
| creator | SANO, SUSUMU UENO, MITSUHIRO KATAYAMA, KAORU NAKAMURA, TERUYA OBAYASHI, AKIRA |
| description | To elevate production of OF4949 byPeuicillium rugulosum OF4949 and to elucidate the pathway of its biosynthesis, mutants were selected on the basis of their resistance to growth inhibition by phenylalanine analogs. A mutant resistant tom-fluorophenylalanine, strain No. M414, had 3-fold the production of the parent. In a study of the biosynthesis of OF4949-I and II, several 14C-labeled compounds were examined as possible precursors of OF4949. L-[14C]Tyrosine and L-[14C]asparagine were incorporated efficiently. Most of the radioactivity of L-[14C]tyrosine was found in the 4-methylisodityrosine (B2) or isodityrosine (B1) moieties, and that of L-[14C]asparagine was in the β-hydroxyasparagine moiety. |
| doi_str_mv | 10.7164/antibiotics.39.1697 |
| format | Article |
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Economical aspects</topic><topic>Other techniques and industries</topic><topic>Penicillium - metabolism</topic><topic>Peptides, Cyclic - biosynthesis</topic><topic>Production of active biomolecules</topic><topic>Tyrosine - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>SANO, SUSUMU</creatorcontrib><creatorcontrib>UENO, MITSUHIRO</creatorcontrib><creatorcontrib>KATAYAMA, KAORU</creatorcontrib><creatorcontrib>NAKAMURA, TERUYA</creatorcontrib><creatorcontrib>OBAYASHI, AKIRA</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>SANO, SUSUMU</au><au>UENO, MITSUHIRO</au><au>KATAYAMA, KAORU</au><au>NAKAMURA, TERUYA</au><au>OBAYASHI, AKIRA</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>OF4949, NEW INHIBITORS OF AMINOPEPTIDASE B: III. 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| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1986, Vol.39(12), pp.1697-1703 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77281516 |
| source | J-STAGE Free; MEDLINE |
| subjects | Aminopeptidases - antagonists & inhibitors Antibiotics Applied sciences Asparagine - metabolism Biological and medical sciences Biotechnology Carbon Radioisotopes Exact sciences and technology Fundamental and applied biological sciences. Psychology Health. Pharmaceutical industry Industrial applications and implications. Economical aspects Other techniques and industries Penicillium - metabolism Peptides, Cyclic - biosynthesis Production of active biomolecules Tyrosine - metabolism |
| title | OF4949, NEW INHIBITORS OF AMINOPEPTIDASE B: III. BIOSYNTHESIS |
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