Evidence of increased intrauterine bone resorption in term infants of mothers with insulin-dependent diabetes

Infants of diabetic mothers (IDMs) have lower bone mineral content than control subjects at birth. We measured cord blood propeptide of type I procollagen (PICP), a marker of bone formation, and telopeptide of type I collagen (ICTP), a marker of bone resorption, in 25 term IDMs and 20 term control s...

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Veröffentlicht in:The Journal of pediatrics 1995-05, Vol.126 (5), p.796-798
Hauptverfasser: Demarini, Sergio, Specker, Bonny L., Sierra, Rosa I., Miodovnik, Menachem, Tsang, Reginald C.
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Sprache:eng
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Zusammenfassung:Infants of diabetic mothers (IDMs) have lower bone mineral content than control subjects at birth. We measured cord blood propeptide of type I procollagen (PICP), a marker of bone formation, and telopeptide of type I collagen (ICTP), a marker of bone resorption, in 25 term IDMs and 20 term control subjects. Concentrations of ICTP were higher in IDMs than in control subjects; there was no difference in PICP concentrations. We conclude that osteoclastic activity appears to be higher in IDMs than in control subjects in utero. (J P EDIATR 1995;126:796 8)
ISSN:0022-3476
1097-6833
DOI:10.1016/S0022-3476(95)70414-0