Basic fibroblast growth factor supports the proliferation of epidermal growth factor-generated neuronal precursor cells of the adult mouse CNS
Stem cells isolated from the CNS of both embryonic and adult mice undergo extensive proliferation in the presence of epidermal growth factor (EGF). Removal of EGF determines the differentiation of these cells into neurons and glia. We have recently demonstrated that basic fibroblast growth factor (b...
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| Veröffentlicht in: | Neuroscience letters 1995-02, Vol.185 (3), p.151-154 |
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| container_end_page | 154 |
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| container_title | Neuroscience letters |
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| creator | Gritti, Angela Cova, Lidia Parati, Eugenio A. Galli, Rossella Vescovi, Angelo L. |
| description | Stem cells isolated from the CNS of both embryonic and adult mice undergo extensive proliferation in the presence of epidermal growth factor (EGF). Removal of EGF determines the differentiation of these cells into neurons and glia. We have recently demonstrated that basic fibroblast growth factor (bFGF) regulates the proliferation of EGF-generated progenitors of the embryonic mouse striatum. We report here that bFGF induces proliferation of some EGF-generated precursors of the adult mouse striatum which, in turn, differentiate in vitro into cells possessing neuron-like morphology and neuronal antigenic properties. These results demonstrate that EGF and bFGF can act sequentially to regulate the de novo generation of neurons from the adult mouse CNS in vitro and suggest the existence of a lineage relationship between EGF- and bFGF-responsive progenitor cells of the adult murine brain. |
| doi_str_mv | 10.1016/0304-3940(95)11247-T |
| format | Article |
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Removal of EGF determines the differentiation of these cells into neurons and glia. We have recently demonstrated that basic fibroblast growth factor (bFGF) regulates the proliferation of EGF-generated progenitors of the embryonic mouse striatum. We report here that bFGF induces proliferation of some EGF-generated precursors of the adult mouse striatum which, in turn, differentiate in vitro into cells possessing neuron-like morphology and neuronal antigenic properties. 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Removal of EGF determines the differentiation of these cells into neurons and glia. We have recently demonstrated that basic fibroblast growth factor (bFGF) regulates the proliferation of EGF-generated progenitors of the embryonic mouse striatum. We report here that bFGF induces proliferation of some EGF-generated precursors of the adult mouse striatum which, in turn, differentiate in vitro into cells possessing neuron-like morphology and neuronal antigenic properties. 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Psychology</subject><subject>Mice</subject><subject>Molecular and cellular biology</subject><subject>Neurogenesis</subject><subject>Responses to growth factors, tumor promotors, other factors</subject><subject>Stem cells</subject><subject>Stem Cells - physiology</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2O1DAQhC0EWoaFNwDJB4TgEGgndpxckGDEn7SCA8PZcuz2rlESB9sB8RI8Mw4zGokLnHzor8rVXYQ8ZPCcAWtfQAO8anoOT3vxjLGay-pwi-xYJ-tK9rK-TXZn5C65l9JXABBM8AtyIaVouOx35Ndrnbyhzg8xDKNOmV7H8CPfUKdNDpGmdVlCzInmG6RLDKN3GHX2YabBUVy8xTjp8W9VdY3zRqGlM64xzAVYIpo1pmJpcBzTpt4stV3HTKewJqT7j5_vkztOjwkfnN5L8uXtm8P-fXX16d2H_aurynAmcyVr4KztrKmZBWPNMEDLOt0KV-tOS9Nb1wjZ9BY7B9CzFjXYwoMDIYa2bS7Jk6NvWenbiimryactmJ6xZFFS1lIy6P4LlhRScGgKyI-giSGliE4t0U86_lQM1NaX2spQWxmqF-pPX-pQZI9O_uswoT2LTgWV-ePTXCejRxf1bHw6Yw0H3nXb7y-PGJajffcYVTIeZ4PWl7tnZYP_d47fba60TA</recordid><startdate>19950213</startdate><enddate>19950213</enddate><creator>Gritti, Angela</creator><creator>Cova, Lidia</creator><creator>Parati, Eugenio A.</creator><creator>Galli, Rossella</creator><creator>Vescovi, Angelo L.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19950213</creationdate><title>Basic fibroblast growth factor supports the proliferation of epidermal growth factor-generated neuronal precursor cells of the adult mouse CNS</title><author>Gritti, Angela ; Cova, Lidia ; Parati, Eugenio A. ; Galli, Rossella ; Vescovi, Angelo L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-7204168dc21d0cdcbb0618a65f2a8a7c9df35739de8f00916ea0d68d0f055b663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult central nervous system</topic><topic>Adult neuroplasticity</topic><topic>Animals</topic><topic>Basic fibroblast growth factor</topic><topic>Biological and medical sciences</topic><topic>Cell Division</topic><topic>Cell physiology</topic><topic>Central Nervous System - physiology</topic><topic>Corpus Striatum</topic><topic>Epidermal growth factor</topic><topic>Epidermal Growth Factor - physiology</topic><topic>Fibroblast Growth Factor 2 - pharmacology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Mice</topic><topic>Molecular and cellular biology</topic><topic>Neurogenesis</topic><topic>Responses to growth factors, tumor promotors, other factors</topic><topic>Stem cells</topic><topic>Stem Cells - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gritti, Angela</creatorcontrib><creatorcontrib>Cova, Lidia</creatorcontrib><creatorcontrib>Parati, Eugenio A.</creatorcontrib><creatorcontrib>Galli, Rossella</creatorcontrib><creatorcontrib>Vescovi, Angelo L.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gritti, Angela</au><au>Cova, Lidia</au><au>Parati, Eugenio A.</au><au>Galli, Rossella</au><au>Vescovi, Angelo L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Basic fibroblast growth factor supports the proliferation of epidermal growth factor-generated neuronal precursor cells of the adult mouse CNS</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1995-02-13</date><risdate>1995</risdate><volume>185</volume><issue>3</issue><spage>151</spage><epage>154</epage><pages>151-154</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>Stem cells isolated from the CNS of both embryonic and adult mice undergo extensive proliferation in the presence of epidermal growth factor (EGF). Removal of EGF determines the differentiation of these cells into neurons and glia. We have recently demonstrated that basic fibroblast growth factor (bFGF) regulates the proliferation of EGF-generated progenitors of the embryonic mouse striatum. We report here that bFGF induces proliferation of some EGF-generated precursors of the adult mouse striatum which, in turn, differentiate in vitro into cells possessing neuron-like morphology and neuronal antigenic properties. These results demonstrate that EGF and bFGF can act sequentially to regulate the de novo generation of neurons from the adult mouse CNS in vitro and suggest the existence of a lineage relationship between EGF- and bFGF-responsive progenitor cells of the adult murine brain.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>7753479</pmid><doi>10.1016/0304-3940(95)11247-T</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0304-3940 |
| ispartof | Neuroscience letters, 1995-02, Vol.185 (3), p.151-154 |
| issn | 0304-3940 1872-7972 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult central nervous system Adult neuroplasticity Animals Basic fibroblast growth factor Biological and medical sciences Cell Division Cell physiology Central Nervous System - physiology Corpus Striatum Epidermal growth factor Epidermal Growth Factor - physiology Fibroblast Growth Factor 2 - pharmacology Fundamental and applied biological sciences. Psychology Mice Molecular and cellular biology Neurogenesis Responses to growth factors, tumor promotors, other factors Stem cells Stem Cells - physiology |
| title | Basic fibroblast growth factor supports the proliferation of epidermal growth factor-generated neuronal precursor cells of the adult mouse CNS |
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