Efficacy of traditional Chinese herbal therapy in vitro. A model system for atopic eczema: inhibition of CD23 expression on blood monocytes
Summary Recently, there has been growing interest in the use of traditional Chinese herbal therapy (TCHT) decoctions for the treatment of atopic eczema (AE). The mode of action of this treatment is still unknown, and in order to investigate this we have analysed the effect of an extract of these her...
Gespeichert in:
| Veröffentlicht in: | British journal of dermatology (1951) 1995-04, Vol.132 (4), p.592-598 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 598 |
|---|---|
| container_issue | 4 |
| container_start_page | 592 |
| container_title | British journal of dermatology (1951) |
| container_volume | 132 |
| creator | LATCHMAN, Y. BUNGY, G.A. ATHERTON, D.J. RUSTIN, M.H.A. BROSTOFF, J. |
| description | Summary Recently, there has been growing interest in the use of traditional Chinese herbal therapy (TCHT) decoctions for the treatment of atopic eczema (AE). The mode of action of this treatment is still unknown, and in order to investigate this we have analysed the effect of an extract of these herbs (TCHTE) on interleukin 4 (IL‐4)‐induced CD23 expression on peripheral blood monocytes from non‐atopic subjects. We found that TCHTE inhibited CD23 expression up to 60% (P |
| doi_str_mv | 10.1111/j.1365-2133.1995.tb08716.x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_77277100</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>77277100</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4362-32b56d048daeac80473e050f56bbf69982fb73ff197e76c805679489a3168fdf3</originalsourceid><addsrcrecordid>eNqVkcFu1DAQhi0EKtvCIyBZCHFLsOPETnpAKmlZQAUkVMTRcpyx1ksSBztLN7wCL43TXe0dX0b2_PONZ36EXlKS0njebFPKeJFklLGUVlWRTg0pBeXp_hFanVKP0YoQIhJScfYUnYewJYQyUpAzdCZEXoqCrtDfG2OsVnrGzuDJq9ZO1g2qw_XGDhAAb8A38TrFqMYZ2wH_tpN3Kb7CvWuhw2EOE_TYOI_V5EarMeg_0KvLqN3Y5oG3wOvrjGHYjx5CeHgacNM510bM4PQ8QXiGnhjVBXh-jBfo-_ubu_pDcvt1_bG-uk10zniWsKwpeEvyslWgdElywSBOZQreNIZXVZmZRjBjaCVA8CgouKjyslKM8tK0hl2g1wfu6N2vHYRJ9jZo6Do1gNsFKUQmBCUkCi8PQu1dCB6MHL3tlZ8lJXJxQm7lsm65rFsuTsijE3Ifi18cu-yaHtpT6XH1Mf_qmFdBq854NWgbTjKWizgaj7K3B9m97WD-jw_Id5-uiyqLgOQAsNGn_Qmg_E_JBROF_PFlLe--Vawmn4lcs3__HLWR</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>77277100</pqid></control><display><type>article</type><title>Efficacy of traditional Chinese herbal therapy in vitro. A model system for atopic eczema: inhibition of CD23 expression on blood monocytes</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>LATCHMAN, Y. ; BUNGY, G.A. ; ATHERTON, D.J. ; RUSTIN, M.H.A. ; BROSTOFF, J.</creator><creatorcontrib>LATCHMAN, Y. ; BUNGY, G.A. ; ATHERTON, D.J. ; RUSTIN, M.H.A. ; BROSTOFF, J.</creatorcontrib><description>Summary Recently, there has been growing interest in the use of traditional Chinese herbal therapy (TCHT) decoctions for the treatment of atopic eczema (AE). The mode of action of this treatment is still unknown, and in order to investigate this we have analysed the effect of an extract of these herbs (TCHTE) on interleukin 4 (IL‐4)‐induced CD23 expression on peripheral blood monocytes from non‐atopic subjects. We found that TCHTE inhibited CD23 expression up to 60% (P <0.001), whereas the placebo extract had no significant effect on CD23 expression. This inhibition was dose‐dependent, and TCHTE was effective at a concentration of 250 μg/ml (P = 0.001). If TCHTE or placebo was added after IL‐4, the action of TCHTE could still be seen at 12 h. This inhibition was not due to cell death, as peripheral blood mononuclear cells (PBMCs) cultured with TCHTE or placebo at a concentration used in these experiments had a similar viability to control cultures. Down‐regulation of the low affinity receptors for IgE on antigen‐presenting cells in patients with AE may contribute to the benefit observed following treatment with TCHT.</description><identifier>ISSN: 0007-0963</identifier><identifier>EISSN: 1365-2133</identifier><identifier>DOI: 10.1111/j.1365-2133.1995.tb08716.x</identifier><identifier>PMID: 7748751</identifier><identifier>CODEN: BJDEAZ</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adult ; Biological and medical sciences ; Cell Survival ; Cells, Cultured ; Dermatitis, Atopic - drug therapy ; Dermatitis, Atopic - immunology ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal - therapeutic use ; Female ; General pharmacology ; Humans ; Interleukin-4 - pharmacology ; Male ; Medical sciences ; Monocytes - drug effects ; Monocytes - immunology ; Pharmacognosy. Homeopathy. Health food ; Pharmacology. Drug treatments ; Receptors, IgE - antagonists & inhibitors ; Receptors, IgE - biosynthesis ; Superoxides - metabolism ; Time Factors</subject><ispartof>British journal of dermatology (1951), 1995-04, Vol.132 (4), p.592-598</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4362-32b56d048daeac80473e050f56bbf69982fb73ff197e76c805679489a3168fdf3</citedby><cites>FETCH-LOGICAL-c4362-32b56d048daeac80473e050f56bbf69982fb73ff197e76c805679489a3168fdf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1365-2133.1995.tb08716.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1365-2133.1995.tb08716.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>309,310,314,777,781,786,787,1412,23911,23912,25121,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3478046$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7748751$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LATCHMAN, Y.</creatorcontrib><creatorcontrib>BUNGY, G.A.</creatorcontrib><creatorcontrib>ATHERTON, D.J.</creatorcontrib><creatorcontrib>RUSTIN, M.H.A.</creatorcontrib><creatorcontrib>BROSTOFF, J.</creatorcontrib><title>Efficacy of traditional Chinese herbal therapy in vitro. A model system for atopic eczema: inhibition of CD23 expression on blood monocytes</title><title>British journal of dermatology (1951)</title><addtitle>Br J Dermatol</addtitle><description>Summary Recently, there has been growing interest in the use of traditional Chinese herbal therapy (TCHT) decoctions for the treatment of atopic eczema (AE). The mode of action of this treatment is still unknown, and in order to investigate this we have analysed the effect of an extract of these herbs (TCHTE) on interleukin 4 (IL‐4)‐induced CD23 expression on peripheral blood monocytes from non‐atopic subjects. We found that TCHTE inhibited CD23 expression up to 60% (P <0.001), whereas the placebo extract had no significant effect on CD23 expression. This inhibition was dose‐dependent, and TCHTE was effective at a concentration of 250 μg/ml (P = 0.001). If TCHTE or placebo was added after IL‐4, the action of TCHTE could still be seen at 12 h. This inhibition was not due to cell death, as peripheral blood mononuclear cells (PBMCs) cultured with TCHTE or placebo at a concentration used in these experiments had a similar viability to control cultures. Down‐regulation of the low affinity receptors for IgE on antigen‐presenting cells in patients with AE may contribute to the benefit observed following treatment with TCHT.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Cell Survival</subject><subject>Cells, Cultured</subject><subject>Dermatitis, Atopic - drug therapy</subject><subject>Dermatitis, Atopic - immunology</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drugs, Chinese Herbal - therapeutic use</subject><subject>Female</subject><subject>General pharmacology</subject><subject>Humans</subject><subject>Interleukin-4 - pharmacology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Monocytes - drug effects</subject><subject>Monocytes - immunology</subject><subject>Pharmacognosy. Homeopathy. Health food</subject><subject>Pharmacology. Drug treatments</subject><subject>Receptors, IgE - antagonists & inhibitors</subject><subject>Receptors, IgE - biosynthesis</subject><subject>Superoxides - metabolism</subject><subject>Time Factors</subject><issn>0007-0963</issn><issn>1365-2133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkcFu1DAQhi0EKtvCIyBZCHFLsOPETnpAKmlZQAUkVMTRcpyx1ksSBztLN7wCL43TXe0dX0b2_PONZ36EXlKS0njebFPKeJFklLGUVlWRTg0pBeXp_hFanVKP0YoQIhJScfYUnYewJYQyUpAzdCZEXoqCrtDfG2OsVnrGzuDJq9ZO1g2qw_XGDhAAb8A38TrFqMYZ2wH_tpN3Kb7CvWuhw2EOE_TYOI_V5EarMeg_0KvLqN3Y5oG3wOvrjGHYjx5CeHgacNM510bM4PQ8QXiGnhjVBXh-jBfo-_ubu_pDcvt1_bG-uk10zniWsKwpeEvyslWgdElywSBOZQreNIZXVZmZRjBjaCVA8CgouKjyslKM8tK0hl2g1wfu6N2vHYRJ9jZo6Do1gNsFKUQmBCUkCi8PQu1dCB6MHL3tlZ8lJXJxQm7lsm65rFsuTsijE3Ifi18cu-yaHtpT6XH1Mf_qmFdBq854NWgbTjKWizgaj7K3B9m97WD-jw_Id5-uiyqLgOQAsNGn_Qmg_E_JBROF_PFlLe--Vawmn4lcs3__HLWR</recordid><startdate>199504</startdate><enddate>199504</enddate><creator>LATCHMAN, Y.</creator><creator>BUNGY, G.A.</creator><creator>ATHERTON, D.J.</creator><creator>RUSTIN, M.H.A.</creator><creator>BROSTOFF, J.</creator><general>Blackwell Publishing Ltd</general><general>Blackwell</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199504</creationdate><title>Efficacy of traditional Chinese herbal therapy in vitro. A model system for atopic eczema: inhibition of CD23 expression on blood monocytes</title><author>LATCHMAN, Y. ; BUNGY, G.A. ; ATHERTON, D.J. ; RUSTIN, M.H.A. ; BROSTOFF, J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4362-32b56d048daeac80473e050f56bbf69982fb73ff197e76c805679489a3168fdf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Cell Survival</topic><topic>Cells, Cultured</topic><topic>Dermatitis, Atopic - drug therapy</topic><topic>Dermatitis, Atopic - immunology</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drugs, Chinese Herbal - therapeutic use</topic><topic>Female</topic><topic>General pharmacology</topic><topic>Humans</topic><topic>Interleukin-4 - pharmacology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Monocytes - drug effects</topic><topic>Monocytes - immunology</topic><topic>Pharmacognosy. Homeopathy. Health food</topic><topic>Pharmacology. Drug treatments</topic><topic>Receptors, IgE - antagonists & inhibitors</topic><topic>Receptors, IgE - biosynthesis</topic><topic>Superoxides - metabolism</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LATCHMAN, Y.</creatorcontrib><creatorcontrib>BUNGY, G.A.</creatorcontrib><creatorcontrib>ATHERTON, D.J.</creatorcontrib><creatorcontrib>RUSTIN, M.H.A.</creatorcontrib><creatorcontrib>BROSTOFF, J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>British journal of dermatology (1951)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LATCHMAN, Y.</au><au>BUNGY, G.A.</au><au>ATHERTON, D.J.</au><au>RUSTIN, M.H.A.</au><au>BROSTOFF, J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Efficacy of traditional Chinese herbal therapy in vitro. A model system for atopic eczema: inhibition of CD23 expression on blood monocytes</atitle><jtitle>British journal of dermatology (1951)</jtitle><addtitle>Br J Dermatol</addtitle><date>1995-04</date><risdate>1995</risdate><volume>132</volume><issue>4</issue><spage>592</spage><epage>598</epage><pages>592-598</pages><issn>0007-0963</issn><eissn>1365-2133</eissn><coden>BJDEAZ</coden><abstract>Summary Recently, there has been growing interest in the use of traditional Chinese herbal therapy (TCHT) decoctions for the treatment of atopic eczema (AE). The mode of action of this treatment is still unknown, and in order to investigate this we have analysed the effect of an extract of these herbs (TCHTE) on interleukin 4 (IL‐4)‐induced CD23 expression on peripheral blood monocytes from non‐atopic subjects. We found that TCHTE inhibited CD23 expression up to 60% (P <0.001), whereas the placebo extract had no significant effect on CD23 expression. This inhibition was dose‐dependent, and TCHTE was effective at a concentration of 250 μg/ml (P = 0.001). If TCHTE or placebo was added after IL‐4, the action of TCHTE could still be seen at 12 h. This inhibition was not due to cell death, as peripheral blood mononuclear cells (PBMCs) cultured with TCHTE or placebo at a concentration used in these experiments had a similar viability to control cultures. Down‐regulation of the low affinity receptors for IgE on antigen‐presenting cells in patients with AE may contribute to the benefit observed following treatment with TCHT.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>7748751</pmid><doi>10.1111/j.1365-2133.1995.tb08716.x</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-0963 |
| ispartof | British journal of dermatology (1951), 1995-04, Vol.132 (4), p.592-598 |
| issn | 0007-0963 1365-2133 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77277100 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adult Biological and medical sciences Cell Survival Cells, Cultured Dermatitis, Atopic - drug therapy Dermatitis, Atopic - immunology Dose-Response Relationship, Drug Drugs, Chinese Herbal - therapeutic use Female General pharmacology Humans Interleukin-4 - pharmacology Male Medical sciences Monocytes - drug effects Monocytes - immunology Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Receptors, IgE - antagonists & inhibitors Receptors, IgE - biosynthesis Superoxides - metabolism Time Factors |
| title | Efficacy of traditional Chinese herbal therapy in vitro. A model system for atopic eczema: inhibition of CD23 expression on blood monocytes |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T18%3A48%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Efficacy%20of%20traditional%20Chinese%20herbal%20therapy%20in%20vitro.%20A%20model%20system%20for%20atopic%20eczema:%20inhibition%20of%20CD23%20expression%20on%20blood%20monocytes&rft.jtitle=British%20journal%20of%20dermatology%20(1951)&rft.au=LATCHMAN,%20Y.&rft.date=1995-04&rft.volume=132&rft.issue=4&rft.spage=592&rft.epage=598&rft.pages=592-598&rft.issn=0007-0963&rft.eissn=1365-2133&rft.coden=BJDEAZ&rft_id=info:doi/10.1111/j.1365-2133.1995.tb08716.x&rft_dat=%3Cproquest_cross%3E77277100%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=77277100&rft_id=info:pmid/7748751&rfr_iscdi=true |