Synthesis and biodistribution of 125I labeled bivalent analogs of practolol as potential myocardial imaging agents

Iodinated bivalent ligands 3 and 4 and a monovalent ligand 5 were prepared from the cardioselective β-antagonist, practolol. 125 I-labeled 3, 4 and 5 were prepared by solid phase isotopic exchange reaction with carrier-free Na 125 I and examined in rats as potential receptor-site-directed myocardial...

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Veröffentlicht in:	International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology Nuclear medicine and biology, 1986, Vol.13 (5), p.551-555
Hauptverfasser:	Kizuka, H., Hanson, R.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Heart - diagnostic imaging Indicators and Reagents Iodine Radioisotopes Kinetics Practolol - analogs & derivatives Practolol - metabolism Radionuclide Imaging Rats Rats, Inbred Strains Tissue Distribution
Online-Zugang:	Volltext
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