Experience of orthotopic liver transplantation and hepatic resection for hepatocellular carcinoma of less than 8 cm in patients with cirrhosis
Fifteen patients with cirrhosis underwent orthotopic liver transplantation for small hepatocellular carcinoma (HCC) and 12 patients with cirrhosis underwent hepatic resection for similar HCC. All tumours were of the non‐fibrolamellar variant. The majority of the patients in the transplant group had...
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| Veröffentlicht in: | British journal of surgery 1995-02, Vol.82 (2), p.253-256 |
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| creator | Tan, K. C. Rela, M. Ryder, S. D. Rizzi, P. M. Karani, J. Portmann, B. Heaton, N. D. Howard, E. R. Williams, R. |
| description | Fifteen patients with cirrhosis underwent orthotopic liver transplantation for small hepatocellular carcinoma (HCC) and 12 patients with cirrhosis underwent hepatic resection for similar HCC. All tumours were of the non‐fibrolamellar variant. The majority of the patients in the transplant group had Child's grade B or C cirrhosis. Median follow‐up was 37 months with a minimum of 18 months. Eleven of 12 patients in the resection group had Child's grade A cirrhosis. Median follow‐up was 29 months with a minimum of 16 months. Actuarial survival rates at 1 and 3 years for the transplanted patients were 80 and 63 per cent and all were tumour free. Tumour recurrence rate was 15 per cent. The overall 1‐ and 3‐year tumour‐free survival rates for patients in the resection group were 61 and 33 percent. Tumour recurrence rate was 45 percent. The results show orthotopic liver transplantation to be an important surgical option in cirrhotic patients with small HCC, particularly in those with moderate to severe hepatic decompensation. |
| doi_str_mv | 10.1002/bjs.1800820239 |
| format | Article |
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C. ; Rela, M. ; Ryder, S. D. ; Rizzi, P. M. ; Karani, J. ; Portmann, B. ; Heaton, N. D. ; Howard, E. R. ; Williams, R.</creator><creatorcontrib>Tan, K. C. ; Rela, M. ; Ryder, S. D. ; Rizzi, P. M. ; Karani, J. ; Portmann, B. ; Heaton, N. D. ; Howard, E. R. ; Williams, R.</creatorcontrib><description>Fifteen patients with cirrhosis underwent orthotopic liver transplantation for small hepatocellular carcinoma (HCC) and 12 patients with cirrhosis underwent hepatic resection for similar HCC. All tumours were of the non‐fibrolamellar variant. The majority of the patients in the transplant group had Child's grade B or C cirrhosis. Median follow‐up was 37 months with a minimum of 18 months. Eleven of 12 patients in the resection group had Child's grade A cirrhosis. Median follow‐up was 29 months with a minimum of 16 months. Actuarial survival rates at 1 and 3 years for the transplanted patients were 80 and 63 per cent and all were tumour free. Tumour recurrence rate was 15 per cent. The overall 1‐ and 3‐year tumour‐free survival rates for patients in the resection group were 61 and 33 percent. Tumour recurrence rate was 45 percent. The results show orthotopic liver transplantation to be an important surgical option in cirrhotic patients with small HCC, particularly in those with moderate to severe hepatic decompensation.</description><identifier>ISSN: 0007-1323</identifier><identifier>EISSN: 1365-2168</identifier><identifier>DOI: 10.1002/bjs.1800820239</identifier><identifier>PMID: 7749704</identifier><identifier>CODEN: BJSUAM</identifier><language>eng</language><publisher>Bristol: John Wiley & Sons, Ltd</publisher><subject>Adult ; Biological and medical sciences ; Carcinoma, Hepatocellular - complications ; Carcinoma, Hepatocellular - pathology ; Carcinoma, Hepatocellular - surgery ; Female ; Follow-Up Studies ; Humans ; Liver Cirrhosis - complications ; Liver Neoplasms - complications ; Liver Neoplasms - pathology ; Liver Neoplasms - surgery ; Liver Transplantation - adverse effects ; Liver Transplantation - methods ; Liver Transplantation - mortality ; Liver, biliary tract, pancreas, portal circulation, spleen ; Male ; Medical sciences ; Middle Aged ; Neoplasm Recurrence, Local ; Recurrence ; Surgery (general aspects). 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Graft diseases ; Surgery of the digestive system ; Survival Analysis ; Time Factors ; Treatment Outcome</subject><ispartof>British journal of surgery, 1995-02, Vol.82 (2), p.253-256</ispartof><rights>Copyright © 1995 British Journal of Surgery Society Ltd.</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3689-35ddb1e3e245006042e89374c4a61035e412aa89d5a0a19a93dcf08f342768d13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbjs.1800820239$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbjs.1800820239$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3447640$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7749704$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tan, K. C.</creatorcontrib><creatorcontrib>Rela, M.</creatorcontrib><creatorcontrib>Ryder, S. D.</creatorcontrib><creatorcontrib>Rizzi, P. M.</creatorcontrib><creatorcontrib>Karani, J.</creatorcontrib><creatorcontrib>Portmann, B.</creatorcontrib><creatorcontrib>Heaton, N. D.</creatorcontrib><creatorcontrib>Howard, E. R.</creatorcontrib><creatorcontrib>Williams, R.</creatorcontrib><title>Experience of orthotopic liver transplantation and hepatic resection for hepatocellular carcinoma of less than 8 cm in patients with cirrhosis</title><title>British journal of surgery</title><addtitle>Br J Surg</addtitle><description>Fifteen patients with cirrhosis underwent orthotopic liver transplantation for small hepatocellular carcinoma (HCC) and 12 patients with cirrhosis underwent hepatic resection for similar HCC. All tumours were of the non‐fibrolamellar variant. The majority of the patients in the transplant group had Child's grade B or C cirrhosis. Median follow‐up was 37 months with a minimum of 18 months. Eleven of 12 patients in the resection group had Child's grade A cirrhosis. Median follow‐up was 29 months with a minimum of 16 months. Actuarial survival rates at 1 and 3 years for the transplanted patients were 80 and 63 per cent and all were tumour free. Tumour recurrence rate was 15 per cent. The overall 1‐ and 3‐year tumour‐free survival rates for patients in the resection group were 61 and 33 percent. Tumour recurrence rate was 45 percent. The results show orthotopic liver transplantation to be an important surgical option in cirrhotic patients with small HCC, particularly in those with moderate to severe hepatic decompensation.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Hepatocellular - complications</subject><subject>Carcinoma, Hepatocellular - pathology</subject><subject>Carcinoma, Hepatocellular - surgery</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Liver Cirrhosis - complications</subject><subject>Liver Neoplasms - complications</subject><subject>Liver Neoplasms - pathology</subject><subject>Liver Neoplasms - surgery</subject><subject>Liver Transplantation - adverse effects</subject><subject>Liver Transplantation - methods</subject><subject>Liver Transplantation - mortality</subject><subject>Liver, biliary tract, pancreas, portal circulation, spleen</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local</subject><subject>Recurrence</subject><subject>Surgery (general aspects). 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Graft diseases</subject><subject>Surgery of the digestive system</subject><subject>Survival Analysis</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><issn>0007-1323</issn><issn>1365-2168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkU9v1DAQxSMEKkvhyg3JB8QtZfwncXKEUgpVBUIF9WjNOhPFJbFT20vbL8FnJsuutidr5v3ekzWvKF5zOOEA4v36Jp3wBqARIGT7pFhxWVel4HXztFgBgC65FPJ58SKlGwAuoRJHxZHWqtWgVsXfs_uZoiNviYWehZiHkMPsLBvdH4osR_RpHtFnzC54hr5jA83LYFmkRPb_tg9xtw2WxnEzYmQWo3U-TLiNHSkllgf0rGF2Ys6zbQL5nNidywOzLsYhJJdeFs96HBO92r_Hxa_PZz9Pv5SX38-_nn64LK2sm7aUVdetOUkSqgKoQQlqWqmVVVhzkBUpLhCbtqsQkLfYys720PRSCV03HZfHxbtd7hzD7YZSNpNL27-jp7BJRmuhRavVAr7Zg5v1RJ2Zo5swPpj9ARf97V7HZHHsl3NZlw6YVErXChas3WF3bqSHg8zBbEs0S4nmsUTz8eLqcVq85c7rUqb7gxfjb1NrqStz_e3cfOIK9NXFD3Mt_wGc86Ef</recordid><startdate>199502</startdate><enddate>199502</enddate><creator>Tan, K. 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R.</au><au>Williams, R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experience of orthotopic liver transplantation and hepatic resection for hepatocellular carcinoma of less than 8 cm in patients with cirrhosis</atitle><jtitle>British journal of surgery</jtitle><addtitle>Br J Surg</addtitle><date>1995-02</date><risdate>1995</risdate><volume>82</volume><issue>2</issue><spage>253</spage><epage>256</epage><pages>253-256</pages><issn>0007-1323</issn><eissn>1365-2168</eissn><coden>BJSUAM</coden><abstract>Fifteen patients with cirrhosis underwent orthotopic liver transplantation for small hepatocellular carcinoma (HCC) and 12 patients with cirrhosis underwent hepatic resection for similar HCC. All tumours were of the non‐fibrolamellar variant. The majority of the patients in the transplant group had Child's grade B or C cirrhosis. Median follow‐up was 37 months with a minimum of 18 months. Eleven of 12 patients in the resection group had Child's grade A cirrhosis. Median follow‐up was 29 months with a minimum of 16 months. Actuarial survival rates at 1 and 3 years for the transplanted patients were 80 and 63 per cent and all were tumour free. Tumour recurrence rate was 15 per cent. The overall 1‐ and 3‐year tumour‐free survival rates for patients in the resection group were 61 and 33 percent. Tumour recurrence rate was 45 percent. The results show orthotopic liver transplantation to be an important surgical option in cirrhotic patients with small HCC, particularly in those with moderate to severe hepatic decompensation.</abstract><cop>Bristol</cop><pub>John Wiley & Sons, Ltd</pub><pmid>7749704</pmid><doi>10.1002/bjs.1800820239</doi><tpages>4</tpages></addata></record> |
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| ispartof | British journal of surgery, 1995-02, Vol.82 (2), p.253-256 |
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| subjects | Adult Biological and medical sciences Carcinoma, Hepatocellular - complications Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - surgery Female Follow-Up Studies Humans Liver Cirrhosis - complications Liver Neoplasms - complications Liver Neoplasms - pathology Liver Neoplasms - surgery Liver Transplantation - adverse effects Liver Transplantation - methods Liver Transplantation - mortality Liver, biliary tract, pancreas, portal circulation, spleen Male Medical sciences Middle Aged Neoplasm Recurrence, Local Recurrence Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Survival Analysis Time Factors Treatment Outcome |
| title | Experience of orthotopic liver transplantation and hepatic resection for hepatocellular carcinoma of less than 8 cm in patients with cirrhosis |
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