Cytotoxic effects of autoxidative glycation

Incubation of the RNA phage Qβ at 37°C with a mixture of 100 mM ribose and 10 μM CuSO 4 resulted in a complete loss of viable phage after 20 min. This cytotoxic effect required both ribose and cupric ions. There was a direct correlation between the decrease in the percentage of phage survival and: (...

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Veröffentlicht in:	Free radical biology & medicine 1995-02, Vol.18 (2), p.265-269
Hauptverfasser:	Carubelli, Raoul, Schneider, J.Edward, Pye, Quentin N., Floyd, Robert A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoxidation Copper - pharmacology Copper Sulfate CuSO 4 Cytotoxicity Free Radicals Glycation Glycosylation Hydrogen Peroxide - metabolism Hydroxyl Radical - metabolism Hydroxyl Radical - pharmacology Oxidation-Reduction Pentetic Acid - pharmacology Phage phage Q beta Ribose Ribose - pharmacology RNA Phages - drug effects Superoxides - metabolism Transition metals
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