Copper addition prevents the inhibitory effects of interleukin 1-β on rat pancreatic islets

Since copper [Cu(II)] is a necessary cofactor for both intra-mitochondrial enzymes involved in energy production and hydroxyl scavenger enzymes, two hypothesised mechanisms for action of interleukin-I beta (IL-1 beta), we studied whether Cu(II) addition could prevent the inhibitory effect of IL-1 be...

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Veröffentlicht in:	Diabetologia 1995, Vol.38 (1), p.39-45
Hauptverfasser:	VINCI, C, CALTABIANO, V, SANTORO, A. M, RABUAZZO, A. M, BUSCEMA, M, PURRELLO, R, RIZZARELLI, E, VIGNERI, R, PURRELO, F
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Cells, Cultured Copper - pharmacology Copper Sulfate Endocrine pancreas Fundamental and applied biological sciences. Psychology Glucose - metabolism Hormones. Régulation Insulin - metabolism Insulin Secretion Interleukin-1 - antagonists & inhibitors Interleukin-1 - pharmacology Islets of Langerhans - cytology Islets of Langerhans - drug effects Islets of Langerhans - metabolism Male Nitric Oxide - biosynthesis Oligopeptides - pharmacology Oxidation-Reduction Rats Rats, Wistar Recombinant Proteins Superoxide Dismutase - metabolism Vertebrates: endocrinology
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