N-methyl-D-aspartate receptors modulate neurotransmitter release and peristalsis in the guinea pig isolated colon
To assess the role of NMDA receptors in modulating neurotransmitter release in the myenteric plexus, we studied the effects of L-glutamic acid and NMDA on endogenous acetylcholine and noradrenaline overflow (assayed by HPLC) from the guinea pig isolated distal colon. L-Glutamic acid and NMDA enhance...
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| Veröffentlicht in: | Neuroscience letters 1995-01, Vol.183 (1-2), p.139-142 |
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| creator | COSENTINO, M DE PONTI, F MARINO, F GIARONI, C LEONI, O LECCHINI, S FRIGO, G |
| description | To assess the role of NMDA receptors in modulating neurotransmitter release in the myenteric plexus, we studied the effects of L-glutamic acid and NMDA on endogenous acetylcholine and noradrenaline overflow (assayed by HPLC) from the guinea pig isolated distal colon. L-Glutamic acid and NMDA enhanced electrically evoked acetylcholine and noradrenaline overflow and these effects were reversed by selective NMDA receptor antagonists. The possible functional significance of these findings was studied by measuring the efficiency of the colonic peristaltic reflex in the presence of NMDA receptor agonists. NMDA inhibited propulsion velocity at all concentrations tested, this effect being antagonized by (+/-)-2-amino-5-phosphonopentanoic acid and virtually abolished in sympathetically denervated animals. In conclusion, the inhibitory effect of NMDA on peristalsis, being almost entirely dependent on the integrity of sympathetic pathways, could be, at least in part, due to NMDA-induced noradrenaline release. |
| doi_str_mv | 10.1016/0304-3940(94)11134-5 |
| format | Article |
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L-Glutamic acid and NMDA enhanced electrically evoked acetylcholine and noradrenaline overflow and these effects were reversed by selective NMDA receptor antagonists. The possible functional significance of these findings was studied by measuring the efficiency of the colonic peristaltic reflex in the presence of NMDA receptor agonists. NMDA inhibited propulsion velocity at all concentrations tested, this effect being antagonized by (+/-)-2-amino-5-phosphonopentanoic acid and virtually abolished in sympathetically denervated animals. In conclusion, the inhibitory effect of NMDA on peristalsis, being almost entirely dependent on the integrity of sympathetic pathways, could be, at least in part, due to NMDA-induced noradrenaline release.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/0304-3940(94)11134-5</identifier><identifier>PMID: 7746475</identifier><identifier>CODEN: NELED5</identifier><language>eng</language><publisher>Shannon: Elsevier</publisher><subject>2-Amino-5-phosphonovalerate - pharmacology ; Acetylcholine - metabolism ; Animals ; Biological and medical sciences ; Colon - physiology ; Fundamental and applied biological sciences. Psychology ; Glutamic Acid - pharmacology ; Guinea Pigs ; Intestine. Mesentery ; Magnesium - pharmacology ; N-Methylaspartate - pharmacology ; Neurotransmitter Agents - metabolism ; Norepinephrine - metabolism ; Peristalsis - physiology ; Receptors, N-Methyl-D-Aspartate - physiology ; Vertebrates: digestive system</subject><ispartof>Neuroscience letters, 1995-01, Vol.183 (1-2), p.139-142</ispartof><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3340567$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7746475$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>COSENTINO, M</creatorcontrib><creatorcontrib>DE PONTI, F</creatorcontrib><creatorcontrib>MARINO, F</creatorcontrib><creatorcontrib>GIARONI, C</creatorcontrib><creatorcontrib>LEONI, O</creatorcontrib><creatorcontrib>LECCHINI, S</creatorcontrib><creatorcontrib>FRIGO, G</creatorcontrib><title>N-methyl-D-aspartate receptors modulate neurotransmitter release and peristalsis in the guinea pig isolated colon</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>To assess the role of NMDA receptors in modulating neurotransmitter release in the myenteric plexus, we studied the effects of L-glutamic acid and NMDA on endogenous acetylcholine and noradrenaline overflow (assayed by HPLC) from the guinea pig isolated distal colon. L-Glutamic acid and NMDA enhanced electrically evoked acetylcholine and noradrenaline overflow and these effects were reversed by selective NMDA receptor antagonists. The possible functional significance of these findings was studied by measuring the efficiency of the colonic peristaltic reflex in the presence of NMDA receptor agonists. NMDA inhibited propulsion velocity at all concentrations tested, this effect being antagonized by (+/-)-2-amino-5-phosphonopentanoic acid and virtually abolished in sympathetically denervated animals. In conclusion, the inhibitory effect of NMDA on peristalsis, being almost entirely dependent on the integrity of sympathetic pathways, could be, at least in part, due to NMDA-induced noradrenaline release.</description><subject>2-Amino-5-phosphonovalerate - pharmacology</subject><subject>Acetylcholine - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Colon - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Glutamic Acid - pharmacology</subject><subject>Guinea Pigs</subject><subject>Intestine. Mesentery</subject><subject>Magnesium - pharmacology</subject><subject>N-Methylaspartate - pharmacology</subject><subject>Neurotransmitter Agents - metabolism</subject><subject>Norepinephrine - metabolism</subject><subject>Peristalsis - physiology</subject><subject>Receptors, N-Methyl-D-Aspartate - physiology</subject><subject>Vertebrates: digestive system</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0EtLAzEUBeAgSq3Vf6CQhYguosnkvZT6hKIbXZfMzJ02Mq8mmUX_vVMs3bq6cM_HWRyELhm9Z5SpB8qpINwKemvFHWOMCyKP0JQZnRFtdXaMpgdyis5i_KGUSibFBE20FkpoOUWbD9JAWm9r8kRc7F1ILgEOUECfuhBx05VDvXu1MIQuBdfGxqcEYTQ1uAjYtSXuIfiYXB19xL7FaQ14NfgWHO79CvvY7SpKXHR1156jk2qUcLG_M_T98vw1fyOLz9f3-eOC9MyaRCyjFQVlKaOSU2PBuEzmOuO0KlylRcUdcG4KsLmRuZJZPm7Clc1LBQaKks_QzV9vH7rNADEtGx8LqGvXQjfEpdbZOAGn_0KmjLFc8RFe7eGQN1Au--AbF7bL_Zhjfr3PXSxcXY1jFT4eGOeCSqX5L-_DhXc</recordid><startdate>19950102</startdate><enddate>19950102</enddate><creator>COSENTINO, M</creator><creator>DE PONTI, F</creator><creator>MARINO, F</creator><creator>GIARONI, C</creator><creator>LEONI, O</creator><creator>LECCHINI, S</creator><creator>FRIGO, G</creator><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>19950102</creationdate><title>N-methyl-D-aspartate receptors modulate neurotransmitter release and peristalsis in the guinea pig isolated colon</title><author>COSENTINO, M ; DE PONTI, F ; MARINO, F ; GIARONI, C ; LEONI, O ; LECCHINI, S ; FRIGO, G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p198t-910f0e6901053089e8a25b7230fcaf74f3ae338ce9b85b652b016369bd6e8ecd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>2-Amino-5-phosphonovalerate - pharmacology</topic><topic>Acetylcholine - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Colon - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Glutamic Acid - pharmacology</topic><topic>Guinea Pigs</topic><topic>Intestine. Mesentery</topic><topic>Magnesium - pharmacology</topic><topic>N-Methylaspartate - pharmacology</topic><topic>Neurotransmitter Agents - metabolism</topic><topic>Norepinephrine - metabolism</topic><topic>Peristalsis - physiology</topic><topic>Receptors, N-Methyl-D-Aspartate - physiology</topic><topic>Vertebrates: digestive system</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>COSENTINO, M</creatorcontrib><creatorcontrib>DE PONTI, F</creatorcontrib><creatorcontrib>MARINO, F</creatorcontrib><creatorcontrib>GIARONI, C</creatorcontrib><creatorcontrib>LEONI, O</creatorcontrib><creatorcontrib>LECCHINI, S</creatorcontrib><creatorcontrib>FRIGO, G</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>COSENTINO, M</au><au>DE PONTI, F</au><au>MARINO, F</au><au>GIARONI, C</au><au>LEONI, O</au><au>LECCHINI, S</au><au>FRIGO, G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>N-methyl-D-aspartate receptors modulate neurotransmitter release and peristalsis in the guinea pig isolated colon</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>1995-01-02</date><risdate>1995</risdate><volume>183</volume><issue>1-2</issue><spage>139</spage><epage>142</epage><pages>139-142</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><coden>NELED5</coden><abstract>To assess the role of NMDA receptors in modulating neurotransmitter release in the myenteric plexus, we studied the effects of L-glutamic acid and NMDA on endogenous acetylcholine and noradrenaline overflow (assayed by HPLC) from the guinea pig isolated distal colon. L-Glutamic acid and NMDA enhanced electrically evoked acetylcholine and noradrenaline overflow and these effects were reversed by selective NMDA receptor antagonists. The possible functional significance of these findings was studied by measuring the efficiency of the colonic peristaltic reflex in the presence of NMDA receptor agonists. NMDA inhibited propulsion velocity at all concentrations tested, this effect being antagonized by (+/-)-2-amino-5-phosphonopentanoic acid and virtually abolished in sympathetically denervated animals. In conclusion, the inhibitory effect of NMDA on peristalsis, being almost entirely dependent on the integrity of sympathetic pathways, could be, at least in part, due to NMDA-induced noradrenaline release.</abstract><cop>Shannon</cop><pub>Elsevier</pub><pmid>7746475</pmid><doi>10.1016/0304-3940(94)11134-5</doi><tpages>4</tpages></addata></record> |
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| ispartof | Neuroscience letters, 1995-01, Vol.183 (1-2), p.139-142 |
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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | 2-Amino-5-phosphonovalerate - pharmacology Acetylcholine - metabolism Animals Biological and medical sciences Colon - physiology Fundamental and applied biological sciences. Psychology Glutamic Acid - pharmacology Guinea Pigs Intestine. Mesentery Magnesium - pharmacology N-Methylaspartate - pharmacology Neurotransmitter Agents - metabolism Norepinephrine - metabolism Peristalsis - physiology Receptors, N-Methyl-D-Aspartate - physiology Vertebrates: digestive system |
| title | N-methyl-D-aspartate receptors modulate neurotransmitter release and peristalsis in the guinea pig isolated colon |
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