Natural killer cell activity and antibody dependent cell-mediated cytotoxicity in preeclampsia
Natural killer cell activity and antibody dependent cell-mediated cytotoxicity (NK and ADCC) of peripheral blood lymphocytes were measured against K-562 and antibody coated HSB target cells with a 4-h chromium release assay in 19 primigravidas with preeclampsia. Nineteen primigravidas with an uncomp...
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| Veröffentlicht in: | Journal of reproductive immunology 1986-11, Vol.9 (3), p.205-212 |
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| container_title | Journal of reproductive immunology |
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| creator | Hill, Joseph A. Hsia, Shyuan Doran, Daniel M. Bryans, C.I. |
| description | Natural killer cell activity and antibody dependent cell-mediated cytotoxicity (NK and ADCC) of peripheral blood lymphocytes were measured against K-562 and antibody coated HSB target cells with a 4-h chromium release assay in 19 primigravidas with preeclampsia. Nineteen primigravidas with an uncomplicated pregnancy and 19 nonpregnant women served as controls. Lymphocyte NK and ADCC activities are significantly lower in primigravidas than in nonpregnant women. Primigravidas with preeclampsia have similar cell-mediated cytotoxic activities to primigravidas with an uncomplicated pregnancy. These findings support the hypothesis that maternal acceptance of the fetal-allograft is due to suppression of cell-mediated cytotoxicity. Altered cellular cytotoxicity appears unlikely as a cause of preeclampsia. Our results, however, do not preclude local changes in cellular immune activities that may occur at the implantation site. |
| doi_str_mv | 10.1016/0165-0378(86)90014-8 |
| format | Article |
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Nineteen primigravidas with an uncomplicated pregnancy and 19 nonpregnant women served as controls. Lymphocyte NK and ADCC activities are significantly lower in primigravidas than in nonpregnant women. Primigravidas with preeclampsia have similar cell-mediated cytotoxic activities to primigravidas with an uncomplicated pregnancy. These findings support the hypothesis that maternal acceptance of the fetal-allograft is due to suppression of cell-mediated cytotoxicity. Altered cellular cytotoxicity appears unlikely as a cause of preeclampsia. 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Placenta ; Puerperal Disorders - immunology ; Reference Values</subject><ispartof>Journal of reproductive immunology, 1986-11, Vol.9 (3), p.205-212</ispartof><rights>1986</rights><rights>1987 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c417t-8d5657e778de477c9d7c81fbf8fabdd81dc9a44e9373668cb3f558f0224386c23</citedby><cites>FETCH-LOGICAL-c417t-8d5657e778de477c9d7c81fbf8fabdd81dc9a44e9373668cb3f558f0224386c23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0165-0378(86)90014-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7957456$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3806528$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hill, Joseph A.</creatorcontrib><creatorcontrib>Hsia, Shyuan</creatorcontrib><creatorcontrib>Doran, Daniel M.</creatorcontrib><creatorcontrib>Bryans, C.I.</creatorcontrib><title>Natural killer cell activity and antibody dependent cell-mediated cytotoxicity in preeclampsia</title><title>Journal of reproductive immunology</title><addtitle>J Reprod Immunol</addtitle><description>Natural killer cell activity and antibody dependent cell-mediated cytotoxicity (NK and ADCC) of peripheral blood lymphocytes were measured against K-562 and antibody coated HSB target cells with a 4-h chromium release assay in 19 primigravidas with preeclampsia. Nineteen primigravidas with an uncomplicated pregnancy and 19 nonpregnant women served as controls. Lymphocyte NK and ADCC activities are significantly lower in primigravidas than in nonpregnant women. Primigravidas with preeclampsia have similar cell-mediated cytotoxic activities to primigravidas with an uncomplicated pregnancy. These findings support the hypothesis that maternal acceptance of the fetal-allograft is due to suppression of cell-mediated cytotoxicity. Altered cellular cytotoxicity appears unlikely as a cause of preeclampsia. Our results, however, do not preclude local changes in cellular immune activities that may occur at the implantation site.</description><subject>antibody dependent cell-mediated cytotoxicity</subject><subject>Antibody-Dependent Cell Cytotoxicity</subject><subject>Biological and medical sciences</subject><subject>cell-mediated immunity</subject><subject>Diseases of mother, fetus and pregnancy</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Humans</subject><subject>Killer Cells, Natural - immunology</subject><subject>Medical sciences</subject><subject>natural killing</subject><subject>Pre-Eclampsia - immunology</subject><subject>preeclampsia</subject><subject>Pregnancy</subject><subject>Pregnancy. Fetus. Placenta</subject><subject>Puerperal Disorders - immunology</subject><subject>Reference Values</subject><issn>0165-0378</issn><issn>1872-7603</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1986</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1v1DAQhi0EKtvCPwApB4TgkGLHX-MLEqooRaroBa5Yjj2RDNkk2N6K_fc43dUe6eHVHOZ5R6OHkFeMXjLK1Ica2VKu4R2o94ZSJlp4QjYMdNdqRflTsjkhz8l5zr8qo6lhZ-SMA1Wygw35-c2VXXJj8zuOI6bG4zg2zpd4H8u-cVOoKbGfw74JuOAUcCoPULvFEF3B0Ph9mcv8N_q1EadmSYh-dNslR_eCPBvcmPHlcV6QH9efv1_dtLd3X75efbptvWC6tBCkkhq1hoBCa2-C9sCGfoDB9SEAC944IdBwzZUC3_NBShho1wkOynf8grw93F3S_GeHudhtzOubbsJ5l63WnTRGskdBJrQCyk0FxQH0ac454WCXFLcu7S2jdvVvV7l2lWtB2Qf_Fmrt9fH-rq-GTqWj8Lp_c9y77N04JDf5mE-YNlILqSr28YBhlXYfMdnsI06-Ok_oiw1z_P8f_wCvAqJM</recordid><startdate>19861101</startdate><enddate>19861101</enddate><creator>Hill, Joseph A.</creator><creator>Hsia, Shyuan</creator><creator>Doran, Daniel M.</creator><creator>Bryans, C.I.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19861101</creationdate><title>Natural killer cell activity and antibody dependent cell-mediated cytotoxicity in preeclampsia</title><author>Hill, Joseph A. ; Hsia, Shyuan ; Doran, Daniel M. ; Bryans, C.I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c417t-8d5657e778de477c9d7c81fbf8fabdd81dc9a44e9373668cb3f558f0224386c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1986</creationdate><topic>antibody dependent cell-mediated cytotoxicity</topic><topic>Antibody-Dependent Cell Cytotoxicity</topic><topic>Biological and medical sciences</topic><topic>cell-mediated immunity</topic><topic>Diseases of mother, fetus and pregnancy</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Humans</topic><topic>Killer Cells, Natural - immunology</topic><topic>Medical sciences</topic><topic>natural killing</topic><topic>Pre-Eclampsia - immunology</topic><topic>preeclampsia</topic><topic>Pregnancy</topic><topic>Pregnancy. Fetus. Placenta</topic><topic>Puerperal Disorders - immunology</topic><topic>Reference Values</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hill, Joseph A.</creatorcontrib><creatorcontrib>Hsia, Shyuan</creatorcontrib><creatorcontrib>Doran, Daniel M.</creatorcontrib><creatorcontrib>Bryans, C.I.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of reproductive immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hill, Joseph A.</au><au>Hsia, Shyuan</au><au>Doran, Daniel M.</au><au>Bryans, C.I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural killer cell activity and antibody dependent cell-mediated cytotoxicity in preeclampsia</atitle><jtitle>Journal of reproductive immunology</jtitle><addtitle>J Reprod Immunol</addtitle><date>1986-11-01</date><risdate>1986</risdate><volume>9</volume><issue>3</issue><spage>205</spage><epage>212</epage><pages>205-212</pages><issn>0165-0378</issn><eissn>1872-7603</eissn><coden>JRIMDR</coden><abstract>Natural killer cell activity and antibody dependent cell-mediated cytotoxicity (NK and ADCC) of peripheral blood lymphocytes were measured against K-562 and antibody coated HSB target cells with a 4-h chromium release assay in 19 primigravidas with preeclampsia. Nineteen primigravidas with an uncomplicated pregnancy and 19 nonpregnant women served as controls. Lymphocyte NK and ADCC activities are significantly lower in primigravidas than in nonpregnant women. Primigravidas with preeclampsia have similar cell-mediated cytotoxic activities to primigravidas with an uncomplicated pregnancy. These findings support the hypothesis that maternal acceptance of the fetal-allograft is due to suppression of cell-mediated cytotoxicity. Altered cellular cytotoxicity appears unlikely as a cause of preeclampsia. Our results, however, do not preclude local changes in cellular immune activities that may occur at the implantation site.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>3806528</pmid><doi>10.1016/0165-0378(86)90014-8</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-0378 |
| ispartof | Journal of reproductive immunology, 1986-11, Vol.9 (3), p.205-212 |
| issn | 0165-0378 1872-7603 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | antibody dependent cell-mediated cytotoxicity Antibody-Dependent Cell Cytotoxicity Biological and medical sciences cell-mediated immunity Diseases of mother, fetus and pregnancy Female Gynecology. Andrology. Obstetrics Humans Killer Cells, Natural - immunology Medical sciences natural killing Pre-Eclampsia - immunology preeclampsia Pregnancy Pregnancy. Fetus. Placenta Puerperal Disorders - immunology Reference Values |
| title | Natural killer cell activity and antibody dependent cell-mediated cytotoxicity in preeclampsia |
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