Rat Serum Osteocalcin Concentration Is Decreased by Restriction of Energy Intake
We studied the effects of energy restriction on serum osteocalcin concentration and bone formation rate in rats. The experiment was designed to achieve energy restriction by reducing the carbohydrate intake while providing identical quantities of protein, fat, vitamins and minerals. Energy intakes o...
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| Veröffentlicht in: | The Journal of nutrition 1995-05, Vol.125 (5), p.1283-1290 |
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| creator | Ndiaye, Biram Cournot, Giulia Pélissier, Marie-Agnès Debray, Odile Walrant Lemonnier, Daniel |
| description | We studied the effects of energy restriction on serum osteocalcin concentration and bone formation rate in rats. The experiment was designed to achieve energy restriction by reducing the carbohydrate intake while providing identical quantities of protein, fat, vitamins and minerals. Energy intakes of three groups of post-weaning male rats were restricted by 20, 40 and 60% for 4 wk. Serum calclum, phosphorus, transthyretin, triiodothyronine (T3), thyroxine (T4), 1,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol and immunoreactive parathyroid hormone (iPTH) concentrations were determined. Energy restriction (20, 40 and 60%) produced a significant and gradual drop of serum osteocalcin concentrations, although the serum concentrations of its key regulators, i.e., 1,25-dihydroxycholecalciferol and iPTH, were not significantly affected. On the contrary, serum concentrations of calcium, phosphorus, transthyretin, T3 and T4 were significantly lower in the energy-restricted groups. However, our results do not support their implication in the regulation of serum osteocalcin synthesis by energy intake. Serum osteocalcin concentration was positively correlated with bone mineral apposition (r = 0.50, P < 0.05) and bone mineralization (r = 0.50, P < 0.05) rates suggesting that its decrease resulted from a reduction of bone formation, and not from abnormal mineralization, because osteoid seam thickness was not modified. Energy intake seems to be an important determinant of serum osteocalcin concentration and bone formation; however, the exact mechanism underlying this regulation remains to be determined. |
| doi_str_mv | 10.1093/jn/125.5.1283 |
| format | Article |
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The experiment was designed to achieve energy restriction by reducing the carbohydrate intake while providing identical quantities of protein, fat, vitamins and minerals. Energy intakes of three groups of post-weaning male rats were restricted by 20, 40 and 60% for 4 wk. Serum calclum, phosphorus, transthyretin, triiodothyronine (T3), thyroxine (T4), 1,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol and immunoreactive parathyroid hormone (iPTH) concentrations were determined. Energy restriction (20, 40 and 60%) produced a significant and gradual drop of serum osteocalcin concentrations, although the serum concentrations of its key regulators, i.e., 1,25-dihydroxycholecalciferol and iPTH, were not significantly affected. On the contrary, serum concentrations of calcium, phosphorus, transthyretin, T3 and T4 were significantly lower in the energy-restricted groups. However, our results do not support their implication in the regulation of serum osteocalcin synthesis by energy intake. Serum osteocalcin concentration was positively correlated with bone mineral apposition (r = 0.50, P < 0.05) and bone mineralization (r = 0.50, P < 0.05) rates suggesting that its decrease resulted from a reduction of bone formation, and not from abnormal mineralization, because osteoid seam thickness was not modified. Energy intake seems to be an important determinant of serum osteocalcin concentration and bone formation; however, the exact mechanism underlying this regulation remains to be determined.</description><identifier>ISSN: 0022-3166</identifier><identifier>EISSN: 1541-6100</identifier><identifier>DOI: 10.1093/jn/125.5.1283</identifier><identifier>PMID: 7738688</identifier><identifier>CODEN: JONUAI</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>ANIMAL MODELS ; Animals ; Biological and medical sciences ; BLOOD PROTEINS ; BLOOD SERUM ; Bone Development - physiology ; BONE FORMATION ; BONE MINERALIZATION ; Bones ; CALCIO ; CALCITRIOL ; Calcitriol - blood ; CALCIUM ; Calcium - blood ; calclum-regulating hormones ; CARBOHIDRATOS ; CARBOHYDRATES ; DIET ; DIETA ; Dietary Carbohydrates - pharmacology ; DOSAGE EFFECTS ; Eating ; Energy Intake - physiology ; ENERGY RESTRICTION ; ESTEROLES ; Feeding. Feeding behavior ; Food Deprivation - physiology ; FOOD INTAKE ; Food, Formulated ; FORMACION OSEA ; FORMATION DES OS ; FOSFORO ; Fundamental and applied biological sciences. Psychology ; GLUCIDE ; Growth - drug effects ; GROWTH RATE ; HORMONAS ; HORMONE ; HORMONES ; HYDROXYCHOLECALCIFEROLS ; INDICE DE CRECIMIENTO ; INGESTION DE ALIMENTOS ; INGESTION DE NUTRIENTES ; INGESTION DE SUBSTANCES NUTRITIVES ; Male ; Medical research ; MODELE ANIMAL ; MODELOS ANIMALES ; NUTRIENT INTAKE ; Nutrition ; osteocalcin ; Osteocalcin - blood ; PARATHYRIN ; Parathyroid Hormone - blood ; PEPTIDE ; PEPTIDES ; PEPTIDOS ; PHOSPHORE ; PHOSPHORUS ; Phosphorus - blood ; Prealbumin - analysis ; PRISE ALIMENTAIRE (HOMME) ; PROTEINAS SANGUINEAS ; PROTEINE SANGUINE ; Random Allocation ; RAT ; RATA ; RATS ; Rats, Sprague-Dawley ; REGIME ALIMENTAIRE ; REGULATION ; Rodents ; SERUM SANGUIN ; STEROL ; STEROLS ; SUERO SANGUINEO ; TAUX DE CROISSANCE ; THYROXINE ; Thyroxine - blood ; TIROXINA ; TRANSTHYRETIN ; TRIIODOTHYRONINE ; Triiodothyronine - blood ; TRIYODOTIRONINA ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; VITAMIN D ; VITAMINA D ; VITAMINE D</subject><ispartof>The Journal of nutrition, 1995-05, Vol.125 (5), p.1283-1290</ispartof><rights>1995 American Society for Nutrition.</rights><rights>1995 INIST-CNRS</rights><rights>Copyright American Institute of Nutrition May 1995</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3530199$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7738688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ndiaye, Biram</creatorcontrib><creatorcontrib>Cournot, Giulia</creatorcontrib><creatorcontrib>Pélissier, Marie-Agnès</creatorcontrib><creatorcontrib>Debray, Odile Walrant</creatorcontrib><creatorcontrib>Lemonnier, Daniel</creatorcontrib><title>Rat Serum Osteocalcin Concentration Is Decreased by Restriction of Energy Intake</title><title>The Journal of nutrition</title><addtitle>J Nutr</addtitle><description>We studied the effects of energy restriction on serum osteocalcin concentration and bone formation rate in rats. The experiment was designed to achieve energy restriction by reducing the carbohydrate intake while providing identical quantities of protein, fat, vitamins and minerals. Energy intakes of three groups of post-weaning male rats were restricted by 20, 40 and 60% for 4 wk. Serum calclum, phosphorus, transthyretin, triiodothyronine (T3), thyroxine (T4), 1,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol and immunoreactive parathyroid hormone (iPTH) concentrations were determined. Energy restriction (20, 40 and 60%) produced a significant and gradual drop of serum osteocalcin concentrations, although the serum concentrations of its key regulators, i.e., 1,25-dihydroxycholecalciferol and iPTH, were not significantly affected. On the contrary, serum concentrations of calcium, phosphorus, transthyretin, T3 and T4 were significantly lower in the energy-restricted groups. However, our results do not support their implication in the regulation of serum osteocalcin synthesis by energy intake. Serum osteocalcin concentration was positively correlated with bone mineral apposition (r = 0.50, P < 0.05) and bone mineralization (r = 0.50, P < 0.05) rates suggesting that its decrease resulted from a reduction of bone formation, and not from abnormal mineralization, because osteoid seam thickness was not modified. Energy intake seems to be an important determinant of serum osteocalcin concentration and bone formation; however, the exact mechanism underlying this regulation remains to be determined.</description><subject>ANIMAL MODELS</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>BLOOD PROTEINS</subject><subject>BLOOD SERUM</subject><subject>Bone Development - physiology</subject><subject>BONE FORMATION</subject><subject>BONE MINERALIZATION</subject><subject>Bones</subject><subject>CALCIO</subject><subject>CALCITRIOL</subject><subject>Calcitriol - blood</subject><subject>CALCIUM</subject><subject>Calcium - blood</subject><subject>calclum-regulating hormones</subject><subject>CARBOHIDRATOS</subject><subject>CARBOHYDRATES</subject><subject>DIET</subject><subject>DIETA</subject><subject>Dietary Carbohydrates - pharmacology</subject><subject>DOSAGE EFFECTS</subject><subject>Eating</subject><subject>Energy Intake - physiology</subject><subject>ENERGY RESTRICTION</subject><subject>ESTEROLES</subject><subject>Feeding. Feeding behavior</subject><subject>Food Deprivation - physiology</subject><subject>FOOD INTAKE</subject><subject>Food, Formulated</subject><subject>FORMACION OSEA</subject><subject>FORMATION DES OS</subject><subject>FOSFORO</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>GLUCIDE</subject><subject>Growth - drug effects</subject><subject>GROWTH RATE</subject><subject>HORMONAS</subject><subject>HORMONE</subject><subject>HORMONES</subject><subject>HYDROXYCHOLECALCIFEROLS</subject><subject>INDICE DE CRECIMIENTO</subject><subject>INGESTION DE ALIMENTOS</subject><subject>INGESTION DE NUTRIENTES</subject><subject>INGESTION DE SUBSTANCES NUTRITIVES</subject><subject>Male</subject><subject>Medical research</subject><subject>MODELE ANIMAL</subject><subject>MODELOS ANIMALES</subject><subject>NUTRIENT INTAKE</subject><subject>Nutrition</subject><subject>osteocalcin</subject><subject>Osteocalcin - blood</subject><subject>PARATHYRIN</subject><subject>Parathyroid Hormone - blood</subject><subject>PEPTIDE</subject><subject>PEPTIDES</subject><subject>PEPTIDOS</subject><subject>PHOSPHORE</subject><subject>PHOSPHORUS</subject><subject>Phosphorus - blood</subject><subject>Prealbumin - analysis</subject><subject>PRISE ALIMENTAIRE (HOMME)</subject><subject>PROTEINAS SANGUINEAS</subject><subject>PROTEINE SANGUINE</subject><subject>Random Allocation</subject><subject>RAT</subject><subject>RATA</subject><subject>RATS</subject><subject>Rats, Sprague-Dawley</subject><subject>REGIME ALIMENTAIRE</subject><subject>REGULATION</subject><subject>Rodents</subject><subject>SERUM SANGUIN</subject><subject>STEROL</subject><subject>STEROLS</subject><subject>SUERO SANGUINEO</subject><subject>TAUX DE CROISSANCE</subject><subject>THYROXINE</subject><subject>Thyroxine - blood</subject><subject>TIROXINA</subject><subject>TRANSTHYRETIN</subject><subject>TRIIODOTHYRONINE</subject><subject>Triiodothyronine - blood</subject><subject>TRIYODOTIRONINA</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>VITAMIN D</subject><subject>VITAMINA D</subject><subject>VITAMINE D</subject><issn>0022-3166</issn><issn>1541-6100</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1rGzEURUVoSJ00yy4LQyndjaPvkZbFSVtDICVp1uJZeg5ybSmVZgL-91Ua00JWb3EOl8e9hLxndM6oFRebdMG4mqs540YckRlTkvWaUfqGzCjlvBdM67fktNYNpZRJa07IyTAIo42ZkR-3MHZ3WKZdd1NHzB62PqZukZPHNBYYY07dsnaX6AtCxdCt9t0t1rFE_5fldXeVsDzsu2Ua4Re-I8dr2FY8P9wzcv_16ufie3998225-HLdoxB87C1KxgNFZFTDStpAzcoqC8EiE4YbsDBoIaXSEAQwaQTlRnKtguBaCxBn5PNL7mPJv6f2kNvF6nG7hYR5qm4YuLLKyCZ-fCVu8lRS-80xO0gurDZN-nCQptUOg3sscQdl7w49Nf7pwKG2itYFko_1nyaUoMza_zFryA4eSlPu7xoYqLRSs8aHF46tmaeIxVUfsVUdYkE_upCjY9Q97-o2ybVdnXLPu4o_1lyPWw</recordid><startdate>19950501</startdate><enddate>19950501</enddate><creator>Ndiaye, Biram</creator><creator>Cournot, Giulia</creator><creator>Pélissier, Marie-Agnès</creator><creator>Debray, Odile Walrant</creator><creator>Lemonnier, Daniel</creator><general>Elsevier Inc</general><general>American Society for Nutritional Sciences</general><general>American Institute of Nutrition</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>19950501</creationdate><title>Rat Serum Osteocalcin Concentration Is Decreased by Restriction of Energy Intake</title><author>Ndiaye, Biram ; Cournot, Giulia ; Pélissier, Marie-Agnès ; Debray, Odile Walrant ; Lemonnier, Daniel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e332t-9e412d0ee106ab49d08b959ad9e13828a9a7634456ad3a14830284265d32663a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>ANIMAL MODELS</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>BLOOD PROTEINS</topic><topic>BLOOD SERUM</topic><topic>Bone Development - physiology</topic><topic>BONE FORMATION</topic><topic>BONE MINERALIZATION</topic><topic>Bones</topic><topic>CALCIO</topic><topic>CALCITRIOL</topic><topic>Calcitriol - blood</topic><topic>CALCIUM</topic><topic>Calcium - blood</topic><topic>calclum-regulating hormones</topic><topic>CARBOHIDRATOS</topic><topic>CARBOHYDRATES</topic><topic>DIET</topic><topic>DIETA</topic><topic>Dietary Carbohydrates - pharmacology</topic><topic>DOSAGE EFFECTS</topic><topic>Eating</topic><topic>Energy Intake - physiology</topic><topic>ENERGY RESTRICTION</topic><topic>ESTEROLES</topic><topic>Feeding. Feeding behavior</topic><topic>Food Deprivation - physiology</topic><topic>FOOD INTAKE</topic><topic>Food, Formulated</topic><topic>FORMACION OSEA</topic><topic>FORMATION DES OS</topic><topic>FOSFORO</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>GLUCIDE</topic><topic>Growth - drug effects</topic><topic>GROWTH RATE</topic><topic>HORMONAS</topic><topic>HORMONE</topic><topic>HORMONES</topic><topic>HYDROXYCHOLECALCIFEROLS</topic><topic>INDICE DE CRECIMIENTO</topic><topic>INGESTION DE ALIMENTOS</topic><topic>INGESTION DE NUTRIENTES</topic><topic>INGESTION DE SUBSTANCES NUTRITIVES</topic><topic>Male</topic><topic>Medical research</topic><topic>MODELE ANIMAL</topic><topic>MODELOS ANIMALES</topic><topic>NUTRIENT INTAKE</topic><topic>Nutrition</topic><topic>osteocalcin</topic><topic>Osteocalcin - blood</topic><topic>PARATHYRIN</topic><topic>Parathyroid Hormone - blood</topic><topic>PEPTIDE</topic><topic>PEPTIDES</topic><topic>PEPTIDOS</topic><topic>PHOSPHORE</topic><topic>PHOSPHORUS</topic><topic>Phosphorus - blood</topic><topic>Prealbumin - analysis</topic><topic>PRISE ALIMENTAIRE (HOMME)</topic><topic>PROTEINAS SANGUINEAS</topic><topic>PROTEINE SANGUINE</topic><topic>Random Allocation</topic><topic>RAT</topic><topic>RATA</topic><topic>RATS</topic><topic>Rats, Sprague-Dawley</topic><topic>REGIME ALIMENTAIRE</topic><topic>REGULATION</topic><topic>Rodents</topic><topic>SERUM SANGUIN</topic><topic>STEROL</topic><topic>STEROLS</topic><topic>SUERO SANGUINEO</topic><topic>TAUX DE CROISSANCE</topic><topic>THYROXINE</topic><topic>Thyroxine - blood</topic><topic>TIROXINA</topic><topic>TRANSTHYRETIN</topic><topic>TRIIODOTHYRONINE</topic><topic>Triiodothyronine - blood</topic><topic>TRIYODOTIRONINA</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>VITAMIN D</topic><topic>VITAMINA D</topic><topic>VITAMINE D</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ndiaye, Biram</creatorcontrib><creatorcontrib>Cournot, Giulia</creatorcontrib><creatorcontrib>Pélissier, Marie-Agnès</creatorcontrib><creatorcontrib>Debray, Odile Walrant</creatorcontrib><creatorcontrib>Lemonnier, Daniel</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ndiaye, Biram</au><au>Cournot, Giulia</au><au>Pélissier, Marie-Agnès</au><au>Debray, Odile Walrant</au><au>Lemonnier, Daniel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rat Serum Osteocalcin Concentration Is Decreased by Restriction of Energy Intake</atitle><jtitle>The Journal of nutrition</jtitle><addtitle>J Nutr</addtitle><date>1995-05-01</date><risdate>1995</risdate><volume>125</volume><issue>5</issue><spage>1283</spage><epage>1290</epage><pages>1283-1290</pages><issn>0022-3166</issn><eissn>1541-6100</eissn><coden>JONUAI</coden><abstract>We studied the effects of energy restriction on serum osteocalcin concentration and bone formation rate in rats. The experiment was designed to achieve energy restriction by reducing the carbohydrate intake while providing identical quantities of protein, fat, vitamins and minerals. Energy intakes of three groups of post-weaning male rats were restricted by 20, 40 and 60% for 4 wk. Serum calclum, phosphorus, transthyretin, triiodothyronine (T3), thyroxine (T4), 1,25-dihydroxycholecalciferol, 25-hydroxycholecalciferol and immunoreactive parathyroid hormone (iPTH) concentrations were determined. Energy restriction (20, 40 and 60%) produced a significant and gradual drop of serum osteocalcin concentrations, although the serum concentrations of its key regulators, i.e., 1,25-dihydroxycholecalciferol and iPTH, were not significantly affected. On the contrary, serum concentrations of calcium, phosphorus, transthyretin, T3 and T4 were significantly lower in the energy-restricted groups. However, our results do not support their implication in the regulation of serum osteocalcin synthesis by energy intake. Serum osteocalcin concentration was positively correlated with bone mineral apposition (r = 0.50, P < 0.05) and bone mineralization (r = 0.50, P < 0.05) rates suggesting that its decrease resulted from a reduction of bone formation, and not from abnormal mineralization, because osteoid seam thickness was not modified. Energy intake seems to be an important determinant of serum osteocalcin concentration and bone formation; however, the exact mechanism underlying this regulation remains to be determined.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>7738688</pmid><doi>10.1093/jn/125.5.1283</doi><tpages>8</tpages></addata></record> |
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| ispartof | The Journal of nutrition, 1995-05, Vol.125 (5), p.1283-1290 |
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| subjects | ANIMAL MODELS Animals Biological and medical sciences BLOOD PROTEINS BLOOD SERUM Bone Development - physiology BONE FORMATION BONE MINERALIZATION Bones CALCIO CALCITRIOL Calcitriol - blood CALCIUM Calcium - blood calclum-regulating hormones CARBOHIDRATOS CARBOHYDRATES DIET DIETA Dietary Carbohydrates - pharmacology DOSAGE EFFECTS Eating Energy Intake - physiology ENERGY RESTRICTION ESTEROLES Feeding. Feeding behavior Food Deprivation - physiology FOOD INTAKE Food, Formulated FORMACION OSEA FORMATION DES OS FOSFORO Fundamental and applied biological sciences. Psychology GLUCIDE Growth - drug effects GROWTH RATE HORMONAS HORMONE HORMONES HYDROXYCHOLECALCIFEROLS INDICE DE CRECIMIENTO INGESTION DE ALIMENTOS INGESTION DE NUTRIENTES INGESTION DE SUBSTANCES NUTRITIVES Male Medical research MODELE ANIMAL MODELOS ANIMALES NUTRIENT INTAKE Nutrition osteocalcin Osteocalcin - blood PARATHYRIN Parathyroid Hormone - blood PEPTIDE PEPTIDES PEPTIDOS PHOSPHORE PHOSPHORUS Phosphorus - blood Prealbumin - analysis PRISE ALIMENTAIRE (HOMME) PROTEINAS SANGUINEAS PROTEINE SANGUINE Random Allocation RAT RATA RATS Rats, Sprague-Dawley REGIME ALIMENTAIRE REGULATION Rodents SERUM SANGUIN STEROL STEROLS SUERO SANGUINEO TAUX DE CROISSANCE THYROXINE Thyroxine - blood TIROXINA TRANSTHYRETIN TRIIODOTHYRONINE Triiodothyronine - blood TRIYODOTIRONINA Vertebrates: anatomy and physiology, studies on body, several organs or systems VITAMIN D VITAMINA D VITAMINE D |
| title | Rat Serum Osteocalcin Concentration Is Decreased by Restriction of Energy Intake |
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