Pepstatin analogs as novel renin inhibitors

Pepstatin analogues corresponding to the general formula A-X-Y-Sta-Ala-Sta-R were synthesized in solution phase. Various changes in the nature of the A, X, and Y groups were made to improve the inhibitory potency against human plasma renin activity. The results were interpreted by use of the active-...

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Veröffentlicht in:	Journal of medicinal chemistry 1986-07, Vol.29 (7), p.1152-1159
Hauptverfasser:	Guegan, Remy, Diaz, Joseph, Cazaubon, Catherine, Beaumont, Michel, Carlet, Claude, Clement, Jacques, Demarne, Henri, Mellet, Michel, Richaud, Jean Paul
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Chemistry Chromatography, Thin Layer Exact sciences and technology Humans Indicators and Reagents Magnetic Resonance Spectroscopy Oligopeptides - chemical synthesis Organic chemistry Pepstatins - chemical synthesis Pepstatins - pharmacology Peptides Preparations and properties Renin - antagonists & inhibitors Renin - blood Structure-Activity Relationship
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