Clinical Outcomes after Transfusion-Associated Hepatitis C
Serologic testing for antibodies to hepatitis C virus (HCV) has shown that over 90 percent of cases of post-transfusion non-A, non-B hepatitis in the United States are caused by HCV. Acute HCV infection is usually not detected clinically. Less than one third of infected patients have jaundice after...
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| Veröffentlicht in: | The New England journal of medicine 1995-06, Vol.332 (22), p.1463-1466 |
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| container_title | The New England journal of medicine |
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| creator | Tong, Myron J El-Farra, Neveen S Reikes, Andrew R Co, Ruth L |
| description | Serologic testing for antibodies to hepatitis C virus (HCV) has shown that over 90 percent of cases of post-transfusion non-A, non-B hepatitis in the United States are caused by HCV. Acute HCV infection is usually not detected clinically. Less than one third of infected patients have jaundice after receiving a transfusion.
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Sustained elevations of serum aminotransferase concentrations for six months or longer have been noted in up to 60 percent of people with post-transfusion non-A, non-B hepatitis. These people have been considered to have chronic hepatitis.
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In a recent study, the detection of HCV RNA in serum from . . . |
| doi_str_mv | 10.1056/NEJM199506013322202 |
| format | Article |
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1
,
2
Sustained elevations of serum aminotransferase concentrations for six months or longer have been noted in up to 60 percent of people with post-transfusion non-A, non-B hepatitis. These people have been considered to have chronic hepatitis.
2
,
3
In a recent study, the detection of HCV RNA in serum from . . .</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJM199506013322202</identifier><identifier>PMID: 7739682</identifier><identifier>CODEN: NEJMAG</identifier><language>eng</language><publisher>Boston, MA: Massachusetts Medical Society</publisher><subject>Adult ; Aged ; Aged, 80 and over ; AIDS/HIV ; Biological and medical sciences ; Biopsy ; Blood & organ donations ; Blood transfusion ; Blood transfusions ; Carcinoma, Hepatocellular - etiology ; Carcinoma, Hepatocellular - mortality ; Chronic active hepatitis ; Chronic Disease ; Cirrhosis ; Clinical outcomes ; Disease Progression ; Fatigue ; Female ; Follow-Up Studies ; Gangrene ; Gastroenterology ; Hemochromatosis ; Hemophilia ; Hepatitis ; Hepatitis B ; Hepatitis C ; Hepatitis C - complications ; Hepatitis C - etiology ; Hepatitis C - physiopathology ; Hepatitis, Chronic - etiology ; Hepatocellular carcinoma ; Hepatology ; HIV ; Hospitals ; Human immunodeficiency virus ; Human viral diseases ; Humans ; Immunoglobulins ; Infections ; Infectious diseases ; Intravenous administration ; Laboratories ; Liver cancer ; Liver cirrhosis ; Liver Cirrhosis - etiology ; Liver diseases ; Liver Failure - etiology ; Liver Failure - mortality ; Liver Neoplasms - etiology ; Liver Neoplasms - mortality ; Liver transplantation ; Male ; Medical sciences ; Middle Aged ; Transfusion Reaction ; Transplantation ; Viral diseases ; Viral hepatitis ; Viral infections</subject><ispartof>The New England journal of medicine, 1995-06, Vol.332 (22), p.1463-1466</ispartof><rights>Copyright © 1995 Massachusetts Medical Society. All rights reserved.</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c653t-a92bdc2ea95ca6ad36681e452b53be2f39a4af86756a7cd3a8da86c097a498af3</citedby><cites>FETCH-LOGICAL-c653t-a92bdc2ea95ca6ad36681e452b53be2f39a4af86756a7cd3a8da86c097a498af3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJM199506013322202$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1983911488?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,777,781,2746,2747,26084,27905,27906,52363,54045,64364,64366,64368,72218</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3560255$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7739682$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tong, Myron J</creatorcontrib><creatorcontrib>El-Farra, Neveen S</creatorcontrib><creatorcontrib>Reikes, Andrew R</creatorcontrib><creatorcontrib>Co, Ruth L</creatorcontrib><title>Clinical Outcomes after Transfusion-Associated Hepatitis C</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Serologic testing for antibodies to hepatitis C virus (HCV) has shown that over 90 percent of cases of post-transfusion non-A, non-B hepatitis in the United States are caused by HCV. Acute HCV infection is usually not detected clinically. Less than one third of infected patients have jaundice after receiving a transfusion.
1
,
2
Sustained elevations of serum aminotransferase concentrations for six months or longer have been noted in up to 60 percent of people with post-transfusion non-A, non-B hepatitis. These people have been considered to have chronic hepatitis.
2
,
3
In a recent study, the detection of HCV RNA in serum from . . .</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>AIDS/HIV</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Blood & organ donations</subject><subject>Blood transfusion</subject><subject>Blood transfusions</subject><subject>Carcinoma, Hepatocellular - etiology</subject><subject>Carcinoma, Hepatocellular - mortality</subject><subject>Chronic active hepatitis</subject><subject>Chronic Disease</subject><subject>Cirrhosis</subject><subject>Clinical outcomes</subject><subject>Disease Progression</subject><subject>Fatigue</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Gangrene</subject><subject>Gastroenterology</subject><subject>Hemochromatosis</subject><subject>Hemophilia</subject><subject>Hepatitis</subject><subject>Hepatitis B</subject><subject>Hepatitis C</subject><subject>Hepatitis C - complications</subject><subject>Hepatitis C - etiology</subject><subject>Hepatitis C - physiopathology</subject><subject>Hepatitis, Chronic - etiology</subject><subject>Hepatocellular carcinoma</subject><subject>Hepatology</subject><subject>HIV</subject><subject>Hospitals</subject><subject>Human immunodeficiency virus</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Immunoglobulins</subject><subject>Infections</subject><subject>Infectious diseases</subject><subject>Intravenous administration</subject><subject>Laboratories</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver Cirrhosis - etiology</subject><subject>Liver diseases</subject><subject>Liver Failure - etiology</subject><subject>Liver Failure - mortality</subject><subject>Liver Neoplasms - etiology</subject><subject>Liver Neoplasms - mortality</subject><subject>Liver transplantation</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Transfusion Reaction</subject><subject>Transplantation</subject><subject>Viral diseases</subject><subject>Viral hepatitis</subject><subject>Viral infections</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqF0UlL7EAQB_BGnvjG0U8gQniKF4n2vniTYdxwueg51HQ60EOWMZUc_Pa2zOBBfNqXOtSvqin-hBwwesao0ueP87sH5pyimjIhOOeUb5EJU0LkUlL9h0wo5TaXxom_ZBdxSdNj0u2QHWOE05ZPyMWsjm30UGdP4-C7JmAG1RD67LmHFqsRY9fml4idjzCEMrsJKxjiEDGb7ZHtCmoM-5s6JS9X8-fZTX7_dH07u7zPvVZiyMHxRel5AKc8aCiF1pYFqfhCiUXglXAgobLaKA3GlwJsCVZ76gxIZ6ESU3Ky3rvqu9cx4FA0EX2oa2hDN2JhDFfaUfcrZNpqyZ1M8N8XuOzGvk1HFJwLZ4VJZUqO_odYIo4xaW1SYq183yH2oSpWfWygfysYLT5SKr5JKU0dbnaPiyaUnzObWFL_eNMHTNlUKQsf8ZMJpSlXKrHTNWsaLNqwbH789B2ObKN6</recordid><startdate>19950601</startdate><enddate>19950601</enddate><creator>Tong, Myron J</creator><creator>El-Farra, Neveen S</creator><creator>Reikes, Andrew R</creator><creator>Co, Ruth L</creator><general>Massachusetts Medical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0TZ</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8AO</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>K0Y</scope><scope>LK8</scope><scope>M0R</scope><scope>M0T</scope><scope>M1P</scope><scope>M2M</scope><scope>M2O</scope><scope>M2P</scope><scope>M7P</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7U9</scope><scope>H94</scope><scope>7X8</scope></search><sort><creationdate>19950601</creationdate><title>Clinical Outcomes after Transfusion-Associated Hepatitis C</title><author>Tong, Myron J ; El-Farra, Neveen S ; Reikes, Andrew R ; Co, Ruth L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c653t-a92bdc2ea95ca6ad36681e452b53be2f39a4af86756a7cd3a8da86c097a498af3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>AIDS/HIV</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Blood & organ donations</topic><topic>Blood transfusion</topic><topic>Blood transfusions</topic><topic>Carcinoma, Hepatocellular - etiology</topic><topic>Carcinoma, Hepatocellular - mortality</topic><topic>Chronic active hepatitis</topic><topic>Chronic Disease</topic><topic>Cirrhosis</topic><topic>Clinical outcomes</topic><topic>Disease Progression</topic><topic>Fatigue</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Gangrene</topic><topic>Gastroenterology</topic><topic>Hemochromatosis</topic><topic>Hemophilia</topic><topic>Hepatitis</topic><topic>Hepatitis B</topic><topic>Hepatitis C</topic><topic>Hepatitis C - complications</topic><topic>Hepatitis C - etiology</topic><topic>Hepatitis C - physiopathology</topic><topic>Hepatitis, Chronic - etiology</topic><topic>Hepatocellular carcinoma</topic><topic>Hepatology</topic><topic>HIV</topic><topic>Hospitals</topic><topic>Human immunodeficiency virus</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Immunoglobulins</topic><topic>Infections</topic><topic>Infectious diseases</topic><topic>Intravenous administration</topic><topic>Laboratories</topic><topic>Liver cancer</topic><topic>Liver cirrhosis</topic><topic>Liver Cirrhosis - 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Academic</collection><jtitle>The New England journal of medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tong, Myron J</au><au>El-Farra, Neveen S</au><au>Reikes, Andrew R</au><au>Co, Ruth L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Outcomes after Transfusion-Associated Hepatitis C</atitle><jtitle>The New England journal of medicine</jtitle><addtitle>N Engl J Med</addtitle><date>1995-06-01</date><risdate>1995</risdate><volume>332</volume><issue>22</issue><spage>1463</spage><epage>1466</epage><pages>1463-1466</pages><issn>0028-4793</issn><eissn>1533-4406</eissn><coden>NEJMAG</coden><abstract>Serologic testing for antibodies to hepatitis C virus (HCV) has shown that over 90 percent of cases of post-transfusion non-A, non-B hepatitis in the United States are caused by HCV. Acute HCV infection is usually not detected clinically. Less than one third of infected patients have jaundice after receiving a transfusion.
1
,
2
Sustained elevations of serum aminotransferase concentrations for six months or longer have been noted in up to 60 percent of people with post-transfusion non-A, non-B hepatitis. These people have been considered to have chronic hepatitis.
2
,
3
In a recent study, the detection of HCV RNA in serum from . . .</abstract><cop>Boston, MA</cop><pub>Massachusetts Medical Society</pub><pmid>7739682</pmid><doi>10.1056/NEJM199506013322202</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0028-4793 |
| ispartof | The New England journal of medicine, 1995-06, Vol.332 (22), p.1463-1466 |
| issn | 0028-4793 1533-4406 |
| language | eng |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; ProQuest Central UK/Ireland; New England Journal of Medicine |
| subjects | Adult Aged Aged, 80 and over AIDS/HIV Biological and medical sciences Biopsy Blood & organ donations Blood transfusion Blood transfusions Carcinoma, Hepatocellular - etiology Carcinoma, Hepatocellular - mortality Chronic active hepatitis Chronic Disease Cirrhosis Clinical outcomes Disease Progression Fatigue Female Follow-Up Studies Gangrene Gastroenterology Hemochromatosis Hemophilia Hepatitis Hepatitis B Hepatitis C Hepatitis C - complications Hepatitis C - etiology Hepatitis C - physiopathology Hepatitis, Chronic - etiology Hepatocellular carcinoma Hepatology HIV Hospitals Human immunodeficiency virus Human viral diseases Humans Immunoglobulins Infections Infectious diseases Intravenous administration Laboratories Liver cancer Liver cirrhosis Liver Cirrhosis - etiology Liver diseases Liver Failure - etiology Liver Failure - mortality Liver Neoplasms - etiology Liver Neoplasms - mortality Liver transplantation Male Medical sciences Middle Aged Transfusion Reaction Transplantation Viral diseases Viral hepatitis Viral infections |
| title | Clinical Outcomes after Transfusion-Associated Hepatitis C |
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