Cardiac involvement in collagen diseases

The purpose of this study is to evaluate the early morphological and functional abnormalities of the heart in patients with collagen disease. The study population was free of risk factors for coronary artery disease and without any clinically evident cardiac manifestations. In 62 patients with colla...

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Veröffentlicht in:European heart journal 1995-02, Vol.16 (2), p.257-262
Hauptverfasser: TOUMANIDIS, S. T., PAPAMICHAEL, C. M., ANTONIADES, L. G., PANTELIA, M. I., SARIDAKIS, N. S., MAVRIKAKIS, M. E., SIDERIS, D. A., MOULOPOULOS, S. D.
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container_issue 2
container_start_page 257
container_title European heart journal
container_volume 16
creator TOUMANIDIS, S. T.
PAPAMICHAEL, C. M.
ANTONIADES, L. G.
PANTELIA, M. I.
SARIDAKIS, N. S.
MAVRIKAKIS, M. E.
SIDERIS, D. A.
MOULOPOULOS, S. D.
description The purpose of this study is to evaluate the early morphological and functional abnormalities of the heart in patients with collagen disease. The study population was free of risk factors for coronary artery disease and without any clinically evident cardiac manifestations. In 62 patients with collagen disease (25 with progressive systemic sclerosis, 19 with systemic lupus erythematosus, 15 with rheumatoid arthritis, three with dermatomyositis) and in 40 healthy subjects an echocardiographic study was performed. Echocardiographic examination from the apical four-chamber view was performed at rest and during the end of a 3 min isometric exercise with handgrip. Global and regional ejection fraction of the left ventricle were calculated In the group with progressive systemic sclerosis the left ventricular mass index was significantly higher than in the control group (110.78 ± 48.61 vs 82.18 ± 28.46g. m−2) and the ejection fraction (53.61 ± 7.95%) was the lowest of all groups (control: 61.47 ± 8.52%, systemic lupus erythematosus: 59.04 ± 8.58%, rheumatoid arthritis: 62.38 ± 6.88%). Regional ejection fraction analysis revealed a major dysfunction of the proximal segment of the interventricular septum, in all groups. During isometric exercise, the global and regional ejection fraction did not change significantly, although differences between groups disappeared. In rheumatoid arthritis, mitral and aortic valve leaflet separation appeared to be reduced. In the group with systemic lupus erythematosus, mild abnormalities were noticed, although the mean age and duration of the disease were the smallest compared with the other groups. In conclusion, patients with progressive systemic sclerosis mainly present left ventricular hypertrophy with a reduced ejection fraction while rheumatoid arthritis patients show a predominant valve dysfunction. In patients with collagen disease, without clinical signs of heart disease or risk factors for coronary artery disease, there are early morphological and functional abnormalities probably due to the primary disease.
doi_str_mv 10.1093/oxfordjournals.eurheartj.a060893
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T. ; PAPAMICHAEL, C. M. ; ANTONIADES, L. G. ; PANTELIA, M. I. ; SARIDAKIS, N. S. ; MAVRIKAKIS, M. E. ; SIDERIS, D. A. ; MOULOPOULOS, S. D.</creator><creatorcontrib>TOUMANIDIS, S. T. ; PAPAMICHAEL, C. M. ; ANTONIADES, L. G. ; PANTELIA, M. I. ; SARIDAKIS, N. S. ; MAVRIKAKIS, M. E. ; SIDERIS, D. A. ; MOULOPOULOS, S. D.</creatorcontrib><description>The purpose of this study is to evaluate the early morphological and functional abnormalities of the heart in patients with collagen disease. The study population was free of risk factors for coronary artery disease and without any clinically evident cardiac manifestations. In 62 patients with collagen disease (25 with progressive systemic sclerosis, 19 with systemic lupus erythematosus, 15 with rheumatoid arthritis, three with dermatomyositis) and in 40 healthy subjects an echocardiographic study was performed. Echocardiographic examination from the apical four-chamber view was performed at rest and during the end of a 3 min isometric exercise with handgrip. Global and regional ejection fraction of the left ventricle were calculated In the group with progressive systemic sclerosis the left ventricular mass index was significantly higher than in the control group (110.78 ± 48.61 vs 82.18 ± 28.46g. m−2) and the ejection fraction (53.61 ± 7.95%) was the lowest of all groups (control: 61.47 ± 8.52%, systemic lupus erythematosus: 59.04 ± 8.58%, rheumatoid arthritis: 62.38 ± 6.88%). Regional ejection fraction analysis revealed a major dysfunction of the proximal segment of the interventricular septum, in all groups. During isometric exercise, the global and regional ejection fraction did not change significantly, although differences between groups disappeared. In rheumatoid arthritis, mitral and aortic valve leaflet separation appeared to be reduced. In the group with systemic lupus erythematosus, mild abnormalities were noticed, although the mean age and duration of the disease were the smallest compared with the other groups. In conclusion, patients with progressive systemic sclerosis mainly present left ventricular hypertrophy with a reduced ejection fraction while rheumatoid arthritis patients show a predominant valve dysfunction. 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Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. 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T.</creatorcontrib><creatorcontrib>PAPAMICHAEL, C. M.</creatorcontrib><creatorcontrib>ANTONIADES, L. G.</creatorcontrib><creatorcontrib>PANTELIA, M. I.</creatorcontrib><creatorcontrib>SARIDAKIS, N. S.</creatorcontrib><creatorcontrib>MAVRIKAKIS, M. E.</creatorcontrib><creatorcontrib>SIDERIS, D. A.</creatorcontrib><creatorcontrib>MOULOPOULOS, S. D.</creatorcontrib><title>Cardiac involvement in collagen diseases</title><title>European heart journal</title><addtitle>Eur Heart J</addtitle><description>The purpose of this study is to evaluate the early morphological and functional abnormalities of the heart in patients with collagen disease. The study population was free of risk factors for coronary artery disease and without any clinically evident cardiac manifestations. 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In patients with collagen disease, without clinical signs of heart disease or risk factors for coronary artery disease, there are early morphological and functional abnormalities probably due to the primary disease.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Biological and medical sciences</subject><subject>Collagen disease</subject><subject>Collagen Diseases - complications</subject><subject>Collagen Diseases - diagnostic imaging</subject><subject>Collagen Diseases - physiopathology</subject><subject>Echocardiography</subject><subject>ejection fraction</subject><subject>Exercise</subject><subject>Female</subject><subject>Heart Diseases - diagnostic imaging</subject><subject>Heart Diseases - etiology</subject><subject>Heart Diseases - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Observer Variation</subject><subject>progressive systemic sclerosis</subject><subject>Reproducibility of Results</subject><subject>rheumatoid arthritis</subject><subject>Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</subject><subject>systemic lupus erythematosus</subject><subject>Ventricular Dysfunction, Left - diagnostic imaging</subject><subject>Ventricular Dysfunction, Left - physiopathology</subject><issn>0195-668X</issn><issn>1522-9645</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkN1LwzAUxYMoOqd_grAHEV86k6ZJmjd1OKcOfFEUX0I-brWzH5q0Mv97O1YKvtx74RzOufwQOid4SrCkF_U6q71b1a2vdBGm0PoP0L5ZTTXmOJV0B40Ii-NI8oTtohEmkkWcp68H6DCEFcY45YTvo30hkgRLOULnM-1dru0kr37q4gdKqJrunti6KPQ7VBOXB9ABwhHay7pKOO73GD3Pb55mi2j5eHs3u1pGlkraRKkRjoFzLDPa8diYOKGEJsZIQkgmGdWWZkzGxlGSmdR0A1IBjPGUJNhyOkZn29wvX3-3EBpV5sFC900FdRuUEDHjjLDOeLk1Wl-H4CFTXz4vtf9VBKsNLPUflhpgqR5WF3HSd7WmBDcE9HQ6_bTXdbC6yLyubB4GG02oFGQTE21teWhgPcjafyouqGBq8fqmFg_L-cPL9VLd0z8y7Yt4</recordid><startdate>19950201</startdate><enddate>19950201</enddate><creator>TOUMANIDIS, S. T.</creator><creator>PAPAMICHAEL, C. M.</creator><creator>ANTONIADES, L. G.</creator><creator>PANTELIA, M. I.</creator><creator>SARIDAKIS, N. S.</creator><creator>MAVRIKAKIS, M. E.</creator><creator>SIDERIS, D. A.</creator><creator>MOULOPOULOS, S. D.</creator><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950201</creationdate><title>Cardiac involvement in collagen diseases</title><author>TOUMANIDIS, S. T. ; PAPAMICHAEL, C. M. ; ANTONIADES, L. G. ; PANTELIA, M. I. ; SARIDAKIS, N. S. ; MAVRIKAKIS, M. E. ; SIDERIS, D. A. ; MOULOPOULOS, S. 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Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis</topic><topic>systemic lupus erythematosus</topic><topic>Ventricular Dysfunction, Left - diagnostic imaging</topic><topic>Ventricular Dysfunction, Left - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>TOUMANIDIS, S. T.</creatorcontrib><creatorcontrib>PAPAMICHAEL, C. M.</creatorcontrib><creatorcontrib>ANTONIADES, L. G.</creatorcontrib><creatorcontrib>PANTELIA, M. I.</creatorcontrib><creatorcontrib>SARIDAKIS, N. S.</creatorcontrib><creatorcontrib>MAVRIKAKIS, M. E.</creatorcontrib><creatorcontrib>SIDERIS, D. A.</creatorcontrib><creatorcontrib>MOULOPOULOS, S. 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D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiac involvement in collagen diseases</atitle><jtitle>European heart journal</jtitle><addtitle>Eur Heart J</addtitle><date>1995-02-01</date><risdate>1995</risdate><volume>16</volume><issue>2</issue><spage>257</spage><epage>262</epage><pages>257-262</pages><issn>0195-668X</issn><eissn>1522-9645</eissn><abstract>The purpose of this study is to evaluate the early morphological and functional abnormalities of the heart in patients with collagen disease. The study population was free of risk factors for coronary artery disease and without any clinically evident cardiac manifestations. In 62 patients with collagen disease (25 with progressive systemic sclerosis, 19 with systemic lupus erythematosus, 15 with rheumatoid arthritis, three with dermatomyositis) and in 40 healthy subjects an echocardiographic study was performed. 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In the group with systemic lupus erythematosus, mild abnormalities were noticed, although the mean age and duration of the disease were the smallest compared with the other groups. In conclusion, patients with progressive systemic sclerosis mainly present left ventricular hypertrophy with a reduced ejection fraction while rheumatoid arthritis patients show a predominant valve dysfunction. In patients with collagen disease, without clinical signs of heart disease or risk factors for coronary artery disease, there are early morphological and functional abnormalities probably due to the primary disease.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>7744099</pmid><doi>10.1093/oxfordjournals.eurheartj.a060893</doi><tpages>6</tpages></addata></record>
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subjects Adolescent
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Collagen disease
Collagen Diseases - complications
Collagen Diseases - diagnostic imaging
Collagen Diseases - physiopathology
Echocardiography
ejection fraction
Exercise
Female
Heart Diseases - diagnostic imaging
Heart Diseases - etiology
Heart Diseases - physiopathology
Humans
Male
Medical sciences
Middle Aged
Observer Variation
progressive systemic sclerosis
Reproducibility of Results
rheumatoid arthritis
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
systemic lupus erythematosus
Ventricular Dysfunction, Left - diagnostic imaging
Ventricular Dysfunction, Left - physiopathology
title Cardiac involvement in collagen diseases
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