The Role of Tyr13 and Lys15 of Interleukin-8 in the High Affinity Interaction with the Interleukin-8 Receptor Type A

Interleukin-8 (IL-8) has at least two binding regions for both the A and the B type IL-8 receptors. This study defines an important region between Cys7 and Cys7 that, together with the Glu4-Leu5-Arg6 sequence of the NH2 terminus, accounts for the high affinity binding of IL-8 to the IL-8 A receptor...

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Veröffentlicht in:	The Journal of biological chemistry 1995-05, Vol.270 (18), p.10428-10431
Hauptverfasser:	Schraufstätter, Ingrid U., Ma, Min, Oades, Zenaida G., Barritt, Diana S., Cochrane, Charles G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Binding, Competitive Calcium - metabolism Chemokine CXCL1 Chemokines, CXC Chemotactic Factors - metabolism Growth Substances - metabolism Humans Intercellular Signaling Peptides and Proteins Interleukin-8 - chemistry Interleukin-8 - metabolism L Cells Mice Molecular Sequence Data Protein Structure, Tertiary Rabbits Receptors, Interleukin - metabolism Receptors, Interleukin-8A Recombinant Fusion Proteins Recombinant Proteins - metabolism Sequence Alignment Species Specificity Structure-Activity Relationship
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