Induction of Apoptosis in HL-60 Cells by Lithium

It has been established that lithium, a preferred drug for the treatment of manic depression, affects the growth of HL-60 cells. Concentrations of lithium above 10 mM were shown to be cytotoxic to these cells. However, the mechanism by which lithium induces its cytotoxicity is still obscure. In this...

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Veröffentlicht in:	Biochemical and biophysical research communications 1995-04, Vol.209 (2), p.768-774
Hauptverfasser:	Madiehe, A.M., Mampuru, L.J., Tyobeka, E.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects Cell Cycle - drug effects Cell Survival - drug effects DNA Damage Dose-Response Relationship, Drug Humans In Vitro Techniques Lithium - pharmacology Tumor Cells, Cultured
Online-Zugang:	Volltext
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