Probes for Narcotic Receptor-Mediated Phenomena. 20. Alteration of Opioid Receptor Subtype Selectivity of the 5-(3-Hydroxyphenyl)morphans by Application of the Message-Address Concept: Preparation of .delta.-Opioid Receptor Ligands

Derivatives of racemic and optically active 5-(3-hydroxyphenyl)-2-methylmorphan (5-(3-hydroxyphenyl)-2-methyl-2-azabicyclo[3.3.1]nonane, 1) were synthesized containing additional aromatic moieties, as an application of the message-address concept targeted at producing delta-opioid receptor selective...

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Veröffentlicht in:	Journal of medicinal chemistry 1995-04, Vol.38 (9), p.1523-1537
Hauptverfasser:	Bertha, Craig M, Flippen-Anderson, Judith L, Rothman, Richard B, Porreca, Frank, Davis, Peg, Xu, Heng, Becketts, Karen, Cha, Xian-Yuan, Rice, Kenner C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Brain - drug effects Brain - metabolism Crystallography, X-Ray Guinea Pigs In Vitro Techniques Ligands Male Mice Mice, Inbred ICR Molecular Probes Morphinans - chemistry Morphinans - metabolism Morphinans - pharmacology Muscle Contraction - drug effects Muscle, Smooth - drug effects Muscle, Smooth - metabolism Protein Binding Receptors, Opioid - drug effects Receptors, Opioid - metabolism Structure-Activity Relationship Vas Deferens - drug effects Vas Deferens - metabolism
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