Isolation and Structure Elucidation of Novel Products of the Acidic Degradation of Diazepam

The acidic degradation of diazepam in methanolic aqueous solution has been investigated. Apart from the known degradation products, 2‐(N‐methylamino)‐5‐chlorobenzophenone and glycine, produced by the hydrolytic cleavage of the benzodiazepinone ring, five novel products were isolated and fully charac...

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Veröffentlicht in:	Journal of pharmaceutical sciences 1995-02, Vol.84 (2), p.208-211
Hauptverfasser:	Sbarbati Nudelman, N., de Waisbaum, R.G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Chromatography, Thin Layer Diazepam - chemistry Drug Stability General pharmacology Hydrolysis Magnetic Resonance Spectroscopy Mass Spectrometry Medical sciences Pharmacology. Drug treatments Physicochemical properties. Structure-activity relationships Spectrophotometry, Infrared Spectrophotometry, Ultraviolet
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