Intrathymic T cell receptor (TcR) targeting in mice lacking CD4 or major histocompatibility complex (MHC) class II: Rescue of CD4 T cell lineage without co‐engagement of TcR/CD4 by MHC class II

A critical step during intrathymic T cell development, termed positive selection, is associated with rescue of short‐lived, immature thymocytes from programmed cell death, T cell lineage commitment, and induction of lineage‐specific differentiation programs. T cell receptor (TcR)‐major histocompatib...

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