Effects of transection and reanastomosis on postprandial jejunal transit and contractile activity
Background. The purpose of this study was to determine how transection and reanastomosis of the intestinal wall influences postprandial motor activity and transit in the small intestine. Methods. Six dogs were each instrumented with 12 strain gauge transducers, two collection cannulas, and an infusi...
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| Veröffentlicht in: | Surgery 1995-05, Vol.117 (5), p.531-537 |
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| creator | Johnson, Christopher P. Sarna, Sushil K. Cowles, Verne E. Baytiyeh, Radwan Zhu, Yong-Ran Buchmann, Ellen Bonham, Laurie Roza, Allan M. Adams, Mark B. |
| description | Background. The purpose of this study was to determine how transection and reanastomosis of the intestinal wall influences postprandial motor activity and transit in the small intestine.
Methods. Six dogs were each instrumented with 12 strain gauge transducers, two collection cannulas, and an infusion catheter defining a 100 cm study segment in the midjejunum. The animals underwent baseline measurements of postprandial motor activity and transit rate after 650 kcal solid and liquid meals. Postprandial motor activity was analyzed by computer methods that identify frequency, duration, amplitude, and propagation behavior of smooth muscle contractions. After the baseline measurements were performed, each animal underwent transection and reanastomosis of the intestinal wall at sites marked during the initial laparotomy. Measurements of postprandial motor activity and transit were repeated and compared with control values.
Results. Transection decreased frequency, amplitude, and percent propagation for postprandial contractions. Total propagating area per minute significantly decreased from 382±20 gram-seconds/minute to 190±66 gram-seconds/minute after transection (p |
| doi_str_mv | 10.1016/S0039-6060(05)80252-1 |
| format | Article |
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Methods. Six dogs were each instrumented with 12 strain gauge transducers, two collection cannulas, and an infusion catheter defining a 100 cm study segment in the midjejunum. The animals underwent baseline measurements of postprandial motor activity and transit rate after 650 kcal solid and liquid meals. Postprandial motor activity was analyzed by computer methods that identify frequency, duration, amplitude, and propagation behavior of smooth muscle contractions. After the baseline measurements were performed, each animal underwent transection and reanastomosis of the intestinal wall at sites marked during the initial laparotomy. Measurements of postprandial motor activity and transit were repeated and compared with control values.
Results. Transection decreased frequency, amplitude, and percent propagation for postprandial contractions. Total propagating area per minute significantly decreased from 382±20 gram-seconds/minute to 190±66 gram-seconds/minute after transection (p<0.05). Intestinal transit decreased from 13.5±1.5 cm/min to 8.5±2.4 cm/min (p<0.05). The change in transit was related primarily to a change in frequency of propagating contractions (r=0.767; p=0.004).
Conclusions. Transection and reanastomosis of the intestinal wall changes the temporal and spatial organization of contractions distal to the transection site. The net result is fewer distally propagating contractions and slower intestinal transit.</description><identifier>ISSN: 0039-6060</identifier><identifier>EISSN: 1532-7361</identifier><identifier>DOI: 10.1016/S0039-6060(05)80252-1</identifier><identifier>PMID: 7740424</identifier><identifier>CODEN: SURGAZ</identifier><language>eng</language><publisher>New York, NY: Mosby, Inc</publisher><subject>Anastomosis, Surgical ; Animals ; Biological and medical sciences ; Dogs ; Eating ; Fasting ; Female ; Functional investigation of the digestive system ; Gastrointestinal Motility ; Gastrointestinal Transit ; Investigative techniques, diagnostic techniques (general aspects) ; Jejunum - physiology ; Jejunum - surgery ; Male ; Medical sciences ; Postoperative Period</subject><ispartof>Surgery, 1995-05, Vol.117 (5), p.531-537</ispartof><rights>1995 Mosby-Year Book, Inc.</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c389t-e5ffe535559b78aa6fae9c7304dc2c60326a87262a8a49b3dc5a2cbfb4a3932e3</citedby><cites>FETCH-LOGICAL-c389t-e5ffe535559b78aa6fae9c7304dc2c60326a87262a8a49b3dc5a2cbfb4a3932e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/S0039-6060(05)80252-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3514901$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7740424$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnson, Christopher P.</creatorcontrib><creatorcontrib>Sarna, Sushil K.</creatorcontrib><creatorcontrib>Cowles, Verne E.</creatorcontrib><creatorcontrib>Baytiyeh, Radwan</creatorcontrib><creatorcontrib>Zhu, Yong-Ran</creatorcontrib><creatorcontrib>Buchmann, Ellen</creatorcontrib><creatorcontrib>Bonham, Laurie</creatorcontrib><creatorcontrib>Roza, Allan M.</creatorcontrib><creatorcontrib>Adams, Mark B.</creatorcontrib><title>Effects of transection and reanastomosis on postprandial jejunal transit and contractile activity</title><title>Surgery</title><addtitle>Surgery</addtitle><description>Background. The purpose of this study was to determine how transection and reanastomosis of the intestinal wall influences postprandial motor activity and transit in the small intestine.
Methods. Six dogs were each instrumented with 12 strain gauge transducers, two collection cannulas, and an infusion catheter defining a 100 cm study segment in the midjejunum. The animals underwent baseline measurements of postprandial motor activity and transit rate after 650 kcal solid and liquid meals. Postprandial motor activity was analyzed by computer methods that identify frequency, duration, amplitude, and propagation behavior of smooth muscle contractions. After the baseline measurements were performed, each animal underwent transection and reanastomosis of the intestinal wall at sites marked during the initial laparotomy. Measurements of postprandial motor activity and transit were repeated and compared with control values.
Results. Transection decreased frequency, amplitude, and percent propagation for postprandial contractions. Total propagating area per minute significantly decreased from 382±20 gram-seconds/minute to 190±66 gram-seconds/minute after transection (p<0.05). Intestinal transit decreased from 13.5±1.5 cm/min to 8.5±2.4 cm/min (p<0.05). The change in transit was related primarily to a change in frequency of propagating contractions (r=0.767; p=0.004).
Conclusions. Transection and reanastomosis of the intestinal wall changes the temporal and spatial organization of contractions distal to the transection site. The net result is fewer distally propagating contractions and slower intestinal transit.</description><subject>Anastomosis, Surgical</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Dogs</subject><subject>Eating</subject><subject>Fasting</subject><subject>Female</subject><subject>Functional investigation of the digestive system</subject><subject>Gastrointestinal Motility</subject><subject>Gastrointestinal Transit</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Jejunum - physiology</subject><subject>Jejunum - surgery</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Postoperative Period</subject><issn>0039-6060</issn><issn>1532-7361</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMlKBDEQhoMo47g8gtAHET20VpJOLycRcYMBD-o5VKerIUNPMiY9gm9vZmGunoqivr-q-Bi74HDLgZd3HwCyyUso4RrUTQ1CiZwfsClXUuSVLPkhm-6RY3YS4xwAmoLXEzapqgIKUUwZPvU9mTFmvs_GgC6mxnqXoeuyQOgwjn7ho02Ay5Y-jssEdRaHbE7zlUt1k7LjJmG8S23aMFC2Lj92_D1jRz0Okc539ZR9PT99Pr7ms_eXt8eHWW5k3Yw5qfSIkkqppq1qxLJHakwloeiMMCVIUWJdiVJgjUXTys4oFKbt2wJlIwXJU3a13bsM_ntFcdQLGw0NAzryq6irKhnitUig2oIm-BgD9XoZ7ALDr-ag12r1Rq1ee9Og9Eat5il3sTuwahfU7VM7l2l-uZtjNDj0yYuxcY9JxYsG1mvutxglGT-Wgo7GkjPU2ZDk687bfx75A30El2E</recordid><startdate>19950501</startdate><enddate>19950501</enddate><creator>Johnson, Christopher P.</creator><creator>Sarna, Sushil K.</creator><creator>Cowles, Verne E.</creator><creator>Baytiyeh, Radwan</creator><creator>Zhu, Yong-Ran</creator><creator>Buchmann, Ellen</creator><creator>Bonham, Laurie</creator><creator>Roza, Allan M.</creator><creator>Adams, Mark B.</creator><general>Mosby, Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950501</creationdate><title>Effects of transection and reanastomosis on postprandial jejunal transit and contractile activity</title><author>Johnson, Christopher P. ; Sarna, Sushil K. ; Cowles, Verne E. ; Baytiyeh, Radwan ; Zhu, Yong-Ran ; Buchmann, Ellen ; Bonham, Laurie ; Roza, Allan M. ; Adams, Mark B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c389t-e5ffe535559b78aa6fae9c7304dc2c60326a87262a8a49b3dc5a2cbfb4a3932e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Anastomosis, Surgical</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Dogs</topic><topic>Eating</topic><topic>Fasting</topic><topic>Female</topic><topic>Functional investigation of the digestive system</topic><topic>Gastrointestinal Motility</topic><topic>Gastrointestinal Transit</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Jejunum - physiology</topic><topic>Jejunum - surgery</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Postoperative Period</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johnson, Christopher P.</creatorcontrib><creatorcontrib>Sarna, Sushil K.</creatorcontrib><creatorcontrib>Cowles, Verne E.</creatorcontrib><creatorcontrib>Baytiyeh, Radwan</creatorcontrib><creatorcontrib>Zhu, Yong-Ran</creatorcontrib><creatorcontrib>Buchmann, Ellen</creatorcontrib><creatorcontrib>Bonham, Laurie</creatorcontrib><creatorcontrib>Roza, Allan M.</creatorcontrib><creatorcontrib>Adams, Mark B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnson, Christopher P.</au><au>Sarna, Sushil K.</au><au>Cowles, Verne E.</au><au>Baytiyeh, Radwan</au><au>Zhu, Yong-Ran</au><au>Buchmann, Ellen</au><au>Bonham, Laurie</au><au>Roza, Allan M.</au><au>Adams, Mark B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of transection and reanastomosis on postprandial jejunal transit and contractile activity</atitle><jtitle>Surgery</jtitle><addtitle>Surgery</addtitle><date>1995-05-01</date><risdate>1995</risdate><volume>117</volume><issue>5</issue><spage>531</spage><epage>537</epage><pages>531-537</pages><issn>0039-6060</issn><eissn>1532-7361</eissn><coden>SURGAZ</coden><abstract>Background. The purpose of this study was to determine how transection and reanastomosis of the intestinal wall influences postprandial motor activity and transit in the small intestine.
Methods. Six dogs were each instrumented with 12 strain gauge transducers, two collection cannulas, and an infusion catheter defining a 100 cm study segment in the midjejunum. The animals underwent baseline measurements of postprandial motor activity and transit rate after 650 kcal solid and liquid meals. Postprandial motor activity was analyzed by computer methods that identify frequency, duration, amplitude, and propagation behavior of smooth muscle contractions. After the baseline measurements were performed, each animal underwent transection and reanastomosis of the intestinal wall at sites marked during the initial laparotomy. Measurements of postprandial motor activity and transit were repeated and compared with control values.
Results. Transection decreased frequency, amplitude, and percent propagation for postprandial contractions. Total propagating area per minute significantly decreased from 382±20 gram-seconds/minute to 190±66 gram-seconds/minute after transection (p<0.05). Intestinal transit decreased from 13.5±1.5 cm/min to 8.5±2.4 cm/min (p<0.05). The change in transit was related primarily to a change in frequency of propagating contractions (r=0.767; p=0.004).
Conclusions. Transection and reanastomosis of the intestinal wall changes the temporal and spatial organization of contractions distal to the transection site. The net result is fewer distally propagating contractions and slower intestinal transit.</abstract><cop>New York, NY</cop><pub>Mosby, Inc</pub><pmid>7740424</pmid><doi>10.1016/S0039-6060(05)80252-1</doi><tpages>7</tpages></addata></record> |
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| subjects | Anastomosis, Surgical Animals Biological and medical sciences Dogs Eating Fasting Female Functional investigation of the digestive system Gastrointestinal Motility Gastrointestinal Transit Investigative techniques, diagnostic techniques (general aspects) Jejunum - physiology Jejunum - surgery Male Medical sciences Postoperative Period |
| title | Effects of transection and reanastomosis on postprandial jejunal transit and contractile activity |
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