Keratinocytes and Fibroblasts in a Human Skin Equivalent Model Enhance Melanocyte Survival and Melanin Synthesis After Ultraviolet Irradiation

To investigate paracrine effects of fibroblasts and keratinocytes on melanocyte behavior after ultraviolet (UV) irradiation, we compared an in vitro skin equivalent model with melanocyte cultures. Human melanocytes were maintained alone in monolayer cultures or on dermal equivalents with or without...

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Veröffentlicht in:	Journal of investigative dermatology 1995-05, Vol.104 (5), p.859-867
Hauptverfasser:	Archambault, Michael, Yaar, Mina, Gilchrest, Barbara A
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Survival - physiology Cell Survival - radiation effects Cells, Cultured - radiation effects Fibroblasts - physiology Humans Infant, Newborn Keratinocytes - physiology Male Melanins - biosynthesis Melanins - radiation effects Melanocytes - cytology Melanocytes - radiation effects melanogenesis paracrine effects Pigmentation - radiation effects Skin - cytology Skin - metabolism Ultraviolet Rays
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