Superinfection of a defective human immunodeficiency virus type 1 provirus-carrying T cell clone with vif or vpu mutants gives cytopathic virus particles by homologous recombination

The partially CD4-expressing T cell clone, Vpr-1, which carries a latent vpr-defective HIV-1 genome and expresses HIV-1 Nef protein only, was permissive to superinfection by HIV-1. Superinfection of Vpr-1 with vif- or vpu-defective mutants, which were noncytopathic, reactivated the vpr-defective vir...

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Veröffentlicht in:	AIDS research and human retroviruses 1995, Vol.11 (1), p.45-53
Hauptverfasser:	KISHI, M, TOKUNAGA, K, YONG-HUI ZHENG, MIRZA KHALIL BAHMANI, KAKINUMA, M, NONOYAMA, M, LAI, P. K, IKUTA, K
Format:	Artikel
Sprache:	eng
Schlagworte:	AIDS/HIV Biological and medical sciences CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - virology Clone Cells Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Viral Gene Products, nef - biosynthesis Gene Products, nef - genetics Gene Products, vif - biosynthesis Gene Products, vif - genetics Gene Products, vpr - biosynthesis Gene Products, vpr - genetics Genetics Genome, Viral HIV Infections - genetics HIV-1 - genetics HIV-1 - pathogenicity human immunodeficiency virus 1 Humans Microbiology Mutation nef Gene Products, Human Immunodeficiency Virus Recombination, Genetic Superinfection - genetics vif Gene Products, Human Immunodeficiency Virus Virology vpr Gene Products, Human Immunodeficiency Virus
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