Long-range sclerotome induction by sonic hedgehog: Direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway

A long-range signal encoded by the Sonic hedgehog ( Shh) gene has been implicated as the ventral patterning influence from the notochord that induces sclerotome and represses dermomyotome in somite differentiation. Long-range effects of hedgehog (hh) signaling have been suggested to result either fr...

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Veröffentlicht in:	Cell 1995-05, Vol.81 (3), p.457-465
Hauptverfasser:	Fan, Chen-Ming, Porter, Jeffery A, Chiang, Chin, Chang, David T, Beachy, Philip A, Tessier-Lavigne, Marc
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biomarkers Bone and Bones - embryology Cell Communication Cells, Cultured Chick Embryo Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Drosophila Embryonic Induction Hedgehog Proteins Mesoderm - physiology Mice Mitogens Muscles - embryology Peptide Fragments - physiology Proteins - metabolism Proteins - physiology Recombinant Proteins - metabolism Ribs - embryology Signal Transduction Skin - embryology Spine - embryology Trans-Activators
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