Human CD5 + B lymphocytes (B-1 cells) decrease in peripheral blood during pregnancy
Pregnancy is a unique immunologic state where a natural homeostasis exists between antigenically different tissues. Several earlier studies have addressed the fluctuations in the number and/or function of lymphocytes, including B cells during pregnancy, but changes within the subsets of B lymphocyte...
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| Veröffentlicht in: | Journal of reproductive immunology 1995, Vol.28 (1), p.53-60 |
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| container_title | Journal of reproductive immunology |
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| creator | Bhat, Neelima M. Mithal, Alka Bieber, Marcia M. Herzenberg, Leonore A. Teng, Nelson N.H. |
| description | Pregnancy is a unique immunologic state where a natural homeostasis exists between antigenically different tissues. Several earlier studies have addressed the fluctuations in the number and/or function of lymphocytes, including B cells during pregnancy, but changes within the subsets of B lymphocytes, conventional (CD5
−) and B-1 (CD5
+), have not been addressed. Here we demonstrate that the frequency of B-1 cells decreases dramatically during pregnancy, whereas the frequency of conventional B cells remains relatively constant. The missing B-1 cells return to pre-pregnancy levels 8–10 weeks after parturition. The polyreactive autoantibodies secreted by B-1 cells have been implicated in autoimmunity and immune regulation. The possible role of B-1 cells during pregnancy will be discussed in that context. |
| doi_str_mv | 10.1016/0165-0378(94)00907-O |
| format | Article |
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−) and B-1 (CD5
+), have not been addressed. Here we demonstrate that the frequency of B-1 cells decreases dramatically during pregnancy, whereas the frequency of conventional B cells remains relatively constant. The missing B-1 cells return to pre-pregnancy levels 8–10 weeks after parturition. The polyreactive autoantibodies secreted by B-1 cells have been implicated in autoimmunity and immune regulation. The possible role of B-1 cells during pregnancy will be discussed in that context.</description><identifier>ISSN: 0165-0378</identifier><identifier>EISSN: 1872-7603</identifier><identifier>DOI: 10.1016/0165-0378(94)00907-O</identifier><identifier>PMID: 7537825</identifier><identifier>CODEN: JRIMDR</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Adult ; Antigens, CD - analysis ; B lymphocytes ; B-Lymphocytes - immunology ; Biological and medical sciences ; CD5 Antigens ; Cross-Sectional Studies ; Female ; Fundamental and applied biological sciences. Psychology ; Human pregnancy ; Humans ; Longitudinal Studies ; Mother. Fetoplacental unit. Mammary gland. Milk ; Pregnancy - immunology ; Pregnancy. Parturition. Lactation ; Vertebrates: reproduction</subject><ispartof>Journal of reproductive immunology, 1995, Vol.28 (1), p.53-60</ispartof><rights>1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-6fa154da34f82a4615e41930be932e067b23ed1120fe0c313c66b8b9b567ad93</citedby><cites>FETCH-LOGICAL-c483t-6fa154da34f82a4615e41930be932e067b23ed1120fe0c313c66b8b9b567ad93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/016503789400907O$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3402510$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7537825$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bhat, Neelima M.</creatorcontrib><creatorcontrib>Mithal, Alka</creatorcontrib><creatorcontrib>Bieber, Marcia M.</creatorcontrib><creatorcontrib>Herzenberg, Leonore A.</creatorcontrib><creatorcontrib>Teng, Nelson N.H.</creatorcontrib><title>Human CD5 + B lymphocytes (B-1 cells) decrease in peripheral blood during pregnancy</title><title>Journal of reproductive immunology</title><addtitle>J Reprod Immunol</addtitle><description>Pregnancy is a unique immunologic state where a natural homeostasis exists between antigenically different tissues. Several earlier studies have addressed the fluctuations in the number and/or function of lymphocytes, including B cells during pregnancy, but changes within the subsets of B lymphocytes, conventional (CD5
−) and B-1 (CD5
+), have not been addressed. Here we demonstrate that the frequency of B-1 cells decreases dramatically during pregnancy, whereas the frequency of conventional B cells remains relatively constant. The missing B-1 cells return to pre-pregnancy levels 8–10 weeks after parturition. The polyreactive autoantibodies secreted by B-1 cells have been implicated in autoimmunity and immune regulation. The possible role of B-1 cells during pregnancy will be discussed in that context.</description><subject>Adult</subject><subject>Antigens, CD - analysis</subject><subject>B lymphocytes</subject><subject>B-Lymphocytes - immunology</subject><subject>Biological and medical sciences</subject><subject>CD5 Antigens</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Human pregnancy</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Mother. Fetoplacental unit. Mammary gland. Milk</subject><subject>Pregnancy - immunology</subject><subject>Pregnancy. Parturition. Lactation</subject><subject>Vertebrates: reproduction</subject><issn>0165-0378</issn><issn>1872-7603</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rGzEQQEVJcZ20_6AFHUpIKNuOVlppdQkkTpoEAj7Ud6GVZm2V_arkLfjfZx0bH3MYBmbeDDOPkK8MfjJg8tcURQZclVdaXANoUNnyA5mzUuWZksDPyPyEfCLnKf0FYAo0m5GZKqZiXszJn6extR1d3Bf0B72jza4dNr3bbTHRq7uMUYdNk66pRxfRJqShowPGMGww2oZWTd976scYujUdIq4727ndZ_Kxtk3CL8d8QVa_H1aLp-xl-fi8uH3JnCj5NpO1ZYXwlou6zK2QrEDBNIcKNc8RpKpyjp6xHGoExxl3UlZlpatCKus1vyCXh7VD7P-NmLamDWl_r-2wH5NRKheaMzmB4gC62KcUsTZDDK2NO8PA7FWavSez92S0MG8qzXIa-3bcP1Yt-tPQ0d3U_37s2-RsU8fp95BOGBeQFwwm7OaA4aTif8BokgvYOfQhotsa34f373gFKCyNTQ</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>Bhat, Neelima M.</creator><creator>Mithal, Alka</creator><creator>Bieber, Marcia M.</creator><creator>Herzenberg, Leonore A.</creator><creator>Teng, Nelson N.H.</creator><general>Elsevier Ireland Ltd</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1995</creationdate><title>Human CD5 + B lymphocytes (B-1 cells) decrease in peripheral blood during pregnancy</title><author>Bhat, Neelima M. ; Mithal, Alka ; Bieber, Marcia M. ; Herzenberg, Leonore A. ; Teng, Nelson N.H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c483t-6fa154da34f82a4615e41930be932e067b23ed1120fe0c313c66b8b9b567ad93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Antigens, CD - analysis</topic><topic>B lymphocytes</topic><topic>B-Lymphocytes - immunology</topic><topic>Biological and medical sciences</topic><topic>CD5 Antigens</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Human pregnancy</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Mother. Fetoplacental unit. Mammary gland. Milk</topic><topic>Pregnancy - immunology</topic><topic>Pregnancy. Parturition. Lactation</topic><topic>Vertebrates: reproduction</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bhat, Neelima M.</creatorcontrib><creatorcontrib>Mithal, Alka</creatorcontrib><creatorcontrib>Bieber, Marcia M.</creatorcontrib><creatorcontrib>Herzenberg, Leonore A.</creatorcontrib><creatorcontrib>Teng, Nelson N.H.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of reproductive immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bhat, Neelima M.</au><au>Mithal, Alka</au><au>Bieber, Marcia M.</au><au>Herzenberg, Leonore A.</au><au>Teng, Nelson N.H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Human CD5 + B lymphocytes (B-1 cells) decrease in peripheral blood during pregnancy</atitle><jtitle>Journal of reproductive immunology</jtitle><addtitle>J Reprod Immunol</addtitle><date>1995</date><risdate>1995</risdate><volume>28</volume><issue>1</issue><spage>53</spage><epage>60</epage><pages>53-60</pages><issn>0165-0378</issn><eissn>1872-7603</eissn><coden>JRIMDR</coden><abstract>Pregnancy is a unique immunologic state where a natural homeostasis exists between antigenically different tissues. Several earlier studies have addressed the fluctuations in the number and/or function of lymphocytes, including B cells during pregnancy, but changes within the subsets of B lymphocytes, conventional (CD5
−) and B-1 (CD5
+), have not been addressed. Here we demonstrate that the frequency of B-1 cells decreases dramatically during pregnancy, whereas the frequency of conventional B cells remains relatively constant. The missing B-1 cells return to pre-pregnancy levels 8–10 weeks after parturition. The polyreactive autoantibodies secreted by B-1 cells have been implicated in autoimmunity and immune regulation. The possible role of B-1 cells during pregnancy will be discussed in that context.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>7537825</pmid><doi>10.1016/0165-0378(94)00907-O</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-0378 |
| ispartof | Journal of reproductive immunology, 1995, Vol.28 (1), p.53-60 |
| issn | 0165-0378 1872-7603 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Antigens, CD - analysis B lymphocytes B-Lymphocytes - immunology Biological and medical sciences CD5 Antigens Cross-Sectional Studies Female Fundamental and applied biological sciences. Psychology Human pregnancy Humans Longitudinal Studies Mother. Fetoplacental unit. Mammary gland. Milk Pregnancy - immunology Pregnancy. Parturition. Lactation Vertebrates: reproduction |
| title | Human CD5 + B lymphocytes (B-1 cells) decrease in peripheral blood during pregnancy |
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