Subclinical Coeliac Disease is a Frequent Cause of Iron-Deficiency Anaemia
Background: Although it is known that anaemia may be the only presenting symptom in coeliac disease, prevalence figures of unsuspected coeliac disease in anaemic patients are not available. The aim of this study was to assess the clinical usefulness of antigliadin and antiendomysial antibody tests i...
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| Veröffentlicht in: | Scandinavian journal of gastroenterology 1995, Vol.30 (2), p.153-156 |
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| container_title | Scandinavian journal of gastroenterology |
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| creator | Corazza, G. R. Valentini, R. A. Andreani, M. L. D'anchino, M. Leva, M. T. Ginaldi, L. De Feudis, L. Quaglino, D. Gasbarrini, G. |
| description | Background: Although it is known that anaemia may be the only presenting symptom in coeliac disease, prevalence figures of unsuspected coeliac disease in anaemic patients are not available. The aim of this study was to assess the clinical usefulness of antigliadin and antiendomysial antibody tests in the diagnostic algorithm of anaemic patients. Methods: Two hundred consecutive anaemic patients were tested for antigliadin antibodies, and those positive were also tested for antiendomysial antibodies. All patients positive for antigliadin and antiendomysial antibodies underwent intestinal biopsy. Results: Sixteen patients were antigliadin antibody-positive, and 10 were also antiendomysial antibody-positive. In all 10 a jejunal biopsy was consistent with coeliac disease (prevalence, 5%). This prevalence rose to 8.5% when patients with macrocytic anaemia or with microcytic anaemia due to previous bleeding or responsive to oral iron therapy were excluded from the calculation. Conclusions: Coeliac disease is a frequent cause of iron-deficiency anaemia, and antigliadin and antiendomysial antibody tests should be always performed in the diagnostic algorithm of anaemic patients. |
| doi_str_mv | 10.3109/00365529509093254 |
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R. ; Valentini, R. A. ; Andreani, M. L. ; D'anchino, M. ; Leva, M. T. ; Ginaldi, L. ; De Feudis, L. ; Quaglino, D. ; Gasbarrini, G.</creator><creatorcontrib>Corazza, G. R. ; Valentini, R. A. ; Andreani, M. L. ; D'anchino, M. ; Leva, M. T. ; Ginaldi, L. ; De Feudis, L. ; Quaglino, D. ; Gasbarrini, G.</creatorcontrib><description>Background: Although it is known that anaemia may be the only presenting symptom in coeliac disease, prevalence figures of unsuspected coeliac disease in anaemic patients are not available. The aim of this study was to assess the clinical usefulness of antigliadin and antiendomysial antibody tests in the diagnostic algorithm of anaemic patients. Methods: Two hundred consecutive anaemic patients were tested for antigliadin antibodies, and those positive were also tested for antiendomysial antibodies. All patients positive for antigliadin and antiendomysial antibodies underwent intestinal biopsy. Results: Sixteen patients were antigliadin antibody-positive, and 10 were also antiendomysial antibody-positive. In all 10 a jejunal biopsy was consistent with coeliac disease (prevalence, 5%). This prevalence rose to 8.5% when patients with macrocytic anaemia or with microcytic anaemia due to previous bleeding or responsive to oral iron therapy were excluded from the calculation. Conclusions: Coeliac disease is a frequent cause of iron-deficiency anaemia, and antigliadin and antiendomysial antibody tests should be always performed in the diagnostic algorithm of anaemic patients.</description><identifier>ISSN: 0036-5521</identifier><identifier>EISSN: 1502-7708</identifier><identifier>DOI: 10.3109/00365529509093254</identifier><identifier>PMID: 7732338</identifier><identifier>CODEN: SJGRA4</identifier><language>eng</language><publisher>Copenhagen: Informa UK Ltd</publisher><subject>Adult ; Anaemia ; Anemia, Iron-Deficiency - etiology ; Anemias. Hemoglobinopathies ; Antibodies - analysis ; antiendomysium antibodies ; antigliadin antibodies ; Biological and medical sciences ; Biopsy ; Celiac Disease - complications ; Celiac Disease - diagnosis ; Celiac Disease - epidemiology ; coeliac disease ; Diseases of red blood cells ; Enzyme-Linked Immunosorbent Assay ; Female ; Gliadin - immunology ; Hematologic and hematopoietic diseases ; Humans ; iron deficiency ; Jejunum - pathology ; Male ; Medical sciences ; Myofibrils - immunology ; Prevalence ; Sensitivity and Specificity</subject><ispartof>Scandinavian journal of gastroenterology, 1995, Vol.30 (2), p.153-156</ispartof><rights>1995 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1995</rights><rights>1995 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-2c1e823aaacabb0f725b37b37ec3fa3ba15c72cdf61c515f5b1a42584dcc6d5a3</citedby><cites>FETCH-LOGICAL-c345t-2c1e823aaacabb0f725b37b37ec3fa3ba15c72cdf61c515f5b1a42584dcc6d5a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.3109/00365529509093254$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.3109/00365529509093254$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,780,784,4024,27923,27924,27925,59647,59753,60436,60542,61221,61256,61402,61437</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=3426678$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7732338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Corazza, G. R.</creatorcontrib><creatorcontrib>Valentini, R. A.</creatorcontrib><creatorcontrib>Andreani, M. L.</creatorcontrib><creatorcontrib>D'anchino, M.</creatorcontrib><creatorcontrib>Leva, M. T.</creatorcontrib><creatorcontrib>Ginaldi, L.</creatorcontrib><creatorcontrib>De Feudis, L.</creatorcontrib><creatorcontrib>Quaglino, D.</creatorcontrib><creatorcontrib>Gasbarrini, G.</creatorcontrib><title>Subclinical Coeliac Disease is a Frequent Cause of Iron-Deficiency Anaemia</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>Background: Although it is known that anaemia may be the only presenting symptom in coeliac disease, prevalence figures of unsuspected coeliac disease in anaemic patients are not available. The aim of this study was to assess the clinical usefulness of antigliadin and antiendomysial antibody tests in the diagnostic algorithm of anaemic patients. Methods: Two hundred consecutive anaemic patients were tested for antigliadin antibodies, and those positive were also tested for antiendomysial antibodies. All patients positive for antigliadin and antiendomysial antibodies underwent intestinal biopsy. Results: Sixteen patients were antigliadin antibody-positive, and 10 were also antiendomysial antibody-positive. In all 10 a jejunal biopsy was consistent with coeliac disease (prevalence, 5%). This prevalence rose to 8.5% when patients with macrocytic anaemia or with microcytic anaemia due to previous bleeding or responsive to oral iron therapy were excluded from the calculation. Conclusions: Coeliac disease is a frequent cause of iron-deficiency anaemia, and antigliadin and antiendomysial antibody tests should be always performed in the diagnostic algorithm of anaemic patients.</description><subject>Adult</subject><subject>Anaemia</subject><subject>Anemia, Iron-Deficiency - etiology</subject><subject>Anemias. Hemoglobinopathies</subject><subject>Antibodies - analysis</subject><subject>antiendomysium antibodies</subject><subject>antigliadin antibodies</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Celiac Disease - complications</subject><subject>Celiac Disease - diagnosis</subject><subject>Celiac Disease - epidemiology</subject><subject>coeliac disease</subject><subject>Diseases of red blood cells</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Female</subject><subject>Gliadin - immunology</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Humans</subject><subject>iron deficiency</subject><subject>Jejunum - pathology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Myofibrils - immunology</subject><subject>Prevalence</subject><subject>Sensitivity and Specificity</subject><issn>0036-5521</issn><issn>1502-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1rFTEUhoMo9Vr9AS6EWYi70XxMJjPoptzaWim4UNfDmTMnNCWT1GSGcv-9udzbggiFQCDv8x5OHsbeCv5RCd5_4ly1Wste8573SurmGdsIzWVtDO-es80-rwsgXrJXOd9yzrVp-hN2YoySSnUb9v3nOqJ3wSH4ahvJO8Dq3GWCTJXLFVQXif6sFJZqC2t5i7a6SjHU52QdOgq4q84C0OzgNXthwWd6c7xP2e-Lr7-23-rrH5dX27PrGlWjl1qioE4qAEAYR26N1KMy5RAqC2oEodFInGwrUAtt9SigkbprJsR20qBO2YfD3LsUy2Z5GWaXkbyHQHHNgzGy6bpeFlAcQEwx50R2uEtuhrQbBB_2_ob__JXOu-PwdZxpemwchZX8_TGHXJTZBAFdfsRUI9vW7LEvB8wFG9MM9zH5aVhg52N66Kintvj8T_2GwC83CImG27imUPQ-8Ye_2QOcfw</recordid><startdate>1995</startdate><enddate>1995</enddate><creator>Corazza, G. R.</creator><creator>Valentini, R. A.</creator><creator>Andreani, M. L.</creator><creator>D'anchino, M.</creator><creator>Leva, M. T.</creator><creator>Ginaldi, L.</creator><creator>De Feudis, L.</creator><creator>Quaglino, D.</creator><creator>Gasbarrini, G.</creator><general>Informa UK Ltd</general><general>Taylor & Francis</general><general>Scandinavian University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1995</creationdate><title>Subclinical Coeliac Disease is a Frequent Cause of Iron-Deficiency Anaemia</title><author>Corazza, G. R. ; Valentini, R. A. ; Andreani, M. L. ; D'anchino, M. ; Leva, M. T. ; Ginaldi, L. ; De Feudis, L. ; Quaglino, D. ; Gasbarrini, G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-2c1e823aaacabb0f725b37b37ec3fa3ba15c72cdf61c515f5b1a42584dcc6d5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Adult</topic><topic>Anaemia</topic><topic>Anemia, Iron-Deficiency - etiology</topic><topic>Anemias. Hemoglobinopathies</topic><topic>Antibodies - analysis</topic><topic>antiendomysium antibodies</topic><topic>antigliadin antibodies</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Celiac Disease - complications</topic><topic>Celiac Disease - diagnosis</topic><topic>Celiac Disease - epidemiology</topic><topic>coeliac disease</topic><topic>Diseases of red blood cells</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Female</topic><topic>Gliadin - immunology</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Humans</topic><topic>iron deficiency</topic><topic>Jejunum - pathology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Myofibrils - immunology</topic><topic>Prevalence</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Corazza, G. R.</creatorcontrib><creatorcontrib>Valentini, R. A.</creatorcontrib><creatorcontrib>Andreani, M. L.</creatorcontrib><creatorcontrib>D'anchino, M.</creatorcontrib><creatorcontrib>Leva, M. T.</creatorcontrib><creatorcontrib>Ginaldi, L.</creatorcontrib><creatorcontrib>De Feudis, L.</creatorcontrib><creatorcontrib>Quaglino, D.</creatorcontrib><creatorcontrib>Gasbarrini, G.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Corazza, G. R.</au><au>Valentini, R. A.</au><au>Andreani, M. L.</au><au>D'anchino, M.</au><au>Leva, M. T.</au><au>Ginaldi, L.</au><au>De Feudis, L.</au><au>Quaglino, D.</au><au>Gasbarrini, G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Subclinical Coeliac Disease is a Frequent Cause of Iron-Deficiency Anaemia</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>1995</date><risdate>1995</risdate><volume>30</volume><issue>2</issue><spage>153</spage><epage>156</epage><pages>153-156</pages><issn>0036-5521</issn><eissn>1502-7708</eissn><coden>SJGRA4</coden><abstract>Background: Although it is known that anaemia may be the only presenting symptom in coeliac disease, prevalence figures of unsuspected coeliac disease in anaemic patients are not available. The aim of this study was to assess the clinical usefulness of antigliadin and antiendomysial antibody tests in the diagnostic algorithm of anaemic patients. Methods: Two hundred consecutive anaemic patients were tested for antigliadin antibodies, and those positive were also tested for antiendomysial antibodies. All patients positive for antigliadin and antiendomysial antibodies underwent intestinal biopsy. Results: Sixteen patients were antigliadin antibody-positive, and 10 were also antiendomysial antibody-positive. In all 10 a jejunal biopsy was consistent with coeliac disease (prevalence, 5%). This prevalence rose to 8.5% when patients with macrocytic anaemia or with microcytic anaemia due to previous bleeding or responsive to oral iron therapy were excluded from the calculation. Conclusions: Coeliac disease is a frequent cause of iron-deficiency anaemia, and antigliadin and antiendomysial antibody tests should be always performed in the diagnostic algorithm of anaemic patients.</abstract><cop>Copenhagen</cop><cop>Oslo</cop><cop>Stockholm</cop><pub>Informa UK Ltd</pub><pmid>7732338</pmid><doi>10.3109/00365529509093254</doi><tpages>4</tpages></addata></record> |
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| ispartof | Scandinavian journal of gastroenterology, 1995, Vol.30 (2), p.153-156 |
| issn | 0036-5521 1502-7708 |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adult Anaemia Anemia, Iron-Deficiency - etiology Anemias. Hemoglobinopathies Antibodies - analysis antiendomysium antibodies antigliadin antibodies Biological and medical sciences Biopsy Celiac Disease - complications Celiac Disease - diagnosis Celiac Disease - epidemiology coeliac disease Diseases of red blood cells Enzyme-Linked Immunosorbent Assay Female Gliadin - immunology Hematologic and hematopoietic diseases Humans iron deficiency Jejunum - pathology Male Medical sciences Myofibrils - immunology Prevalence Sensitivity and Specificity |
| title | Subclinical Coeliac Disease is a Frequent Cause of Iron-Deficiency Anaemia |
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