Feeding premature newborn infants palmitic acid in amounts and stereoisomeric position similar to that of human milk: effects on fat and mineral balance
The effect of the structure of human milk triglycerides on intestinal fat absorption remains controversial. Twelve infants were each fed, for 1 wk in a crossover design, two formulas that differed only in triglyceride configuration. The "beta" formula contained triglycerides similar to tho...
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| Veröffentlicht in: | The American journal of clinical nutrition 1995-05, Vol.61 (5), p.1037-1042 |
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| container_title | The American journal of clinical nutrition |
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| creator | Carnielli, VP Luijendijk, IH van Goudoever, JB Sulkers, EJ Boerlage, AA Degenhart, HJ Sauer, PJ |
| description | The effect of the structure of human milk triglycerides on intestinal fat absorption remains controversial. Twelve infants were each fed, for 1 wk in a crossover design, two formulas that differed only in triglyceride configuration. The "beta" formula contained triglycerides similar to those in human milk (26% palmitic acid, esterified predominantly to the sn-2 position) whereas in the "alpha" formula, which contained triglycerides similar to those in formulas currently marketed, palmitate was mainly at the sn-1,3 positions. Fatty acid, fat, and mineral balances were measured at the end of each 1-wk period. Myristic, palmitic, and stearic acids were absorbed better from the beta formula, but total fat excretion was not reduced. During the feeding of beta formula fecal calcium excretion was lower, urinary calcium higher, and urinary phosphate lower. A formula containing triglycerides similar to those in human milk has significant effects on fatty acid intestinal absorption and improves mineral balance in comparison with a conventional formula. |
| doi_str_mv | 10.1093/ajcn/61.5.1037 |
| format | Article |
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Twelve infants were each fed, for 1 wk in a crossover design, two formulas that differed only in triglyceride configuration. The "beta" formula contained triglycerides similar to those in human milk (26% palmitic acid, esterified predominantly to the sn-2 position) whereas in the "alpha" formula, which contained triglycerides similar to those in formulas currently marketed, palmitate was mainly at the sn-1,3 positions. Fatty acid, fat, and mineral balances were measured at the end of each 1-wk period. Myristic, palmitic, and stearic acids were absorbed better from the beta formula, but total fat excretion was not reduced. During the feeding of beta formula fecal calcium excretion was lower, urinary calcium higher, and urinary phosphate lower. A formula containing triglycerides similar to those in human milk has significant effects on fatty acid intestinal absorption and improves mineral balance in comparison with a conventional formula.</description><identifier>ISSN: 0002-9165</identifier><identifier>EISSN: 1938-3207</identifier><identifier>DOI: 10.1093/ajcn/61.5.1037</identifier><identifier>PMID: 7733025</identifier><identifier>CODEN: AJCNAC</identifier><language>eng</language><publisher>Bethesda, MD: Elsevier Inc</publisher><subject>Administration, Oral ; Babies ; Baby foods ; Biological and medical sciences ; Calcium ; Calcium - pharmacokinetics ; Clinical trials ; Cross-Over Studies ; Fatty Acids - administration & dosage ; Fatty Acids - analysis ; Fatty Acids - pharmacokinetics ; Feces - chemistry ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Humans ; Infant Food - standards ; Infant Nutritional Physiological Phenomena ; Infant, Newborn ; Infant, Premature - metabolism ; Infant, Premature - physiology ; Intestinal Absorption ; Lipid Metabolism ; Lipids ; Milk, Human - chemistry ; Milk, Human - physiology ; Minerals - metabolism ; Nutrition ; Palmitic Acid ; Palmitic Acids - administration & dosage ; Palmitic Acids - chemistry ; Palmitic Acids - pharmacology ; Stereoisomerism ; Triglycerides - chemistry ; Triglycerides - metabolism ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>The American journal of clinical nutrition, 1995-05, Vol.61 (5), p.1037-1042</ispartof><rights>1995 American Society for Nutrition.</rights><rights>1995 INIST-CNRS</rights><rights>Copyright American Society for Clinical Nutrition, Inc. 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Twelve infants were each fed, for 1 wk in a crossover design, two formulas that differed only in triglyceride configuration. The "beta" formula contained triglycerides similar to those in human milk (26% palmitic acid, esterified predominantly to the sn-2 position) whereas in the "alpha" formula, which contained triglycerides similar to those in formulas currently marketed, palmitate was mainly at the sn-1,3 positions. Fatty acid, fat, and mineral balances were measured at the end of each 1-wk period. Myristic, palmitic, and stearic acids were absorbed better from the beta formula, but total fat excretion was not reduced. During the feeding of beta formula fecal calcium excretion was lower, urinary calcium higher, and urinary phosphate lower. A formula containing triglycerides similar to those in human milk has significant effects on fatty acid intestinal absorption and improves mineral balance in comparison with a conventional formula.</description><subject>Administration, Oral</subject><subject>Babies</subject><subject>Baby foods</subject><subject>Biological and medical sciences</subject><subject>Calcium</subject><subject>Calcium - pharmacokinetics</subject><subject>Clinical trials</subject><subject>Cross-Over Studies</subject><subject>Fatty Acids - administration & dosage</subject><subject>Fatty Acids - analysis</subject><subject>Fatty Acids - pharmacokinetics</subject><subject>Feces - chemistry</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Infant Food - standards</subject><subject>Infant Nutritional Physiological Phenomena</subject><subject>Infant, Newborn</subject><subject>Infant, Premature - metabolism</subject><subject>Infant, Premature - physiology</subject><subject>Intestinal Absorption</subject><subject>Lipid Metabolism</subject><subject>Lipids</subject><subject>Milk, Human - chemistry</subject><subject>Milk, Human - physiology</subject><subject>Minerals - metabolism</subject><subject>Nutrition</subject><subject>Palmitic Acid</subject><subject>Palmitic Acids - administration & dosage</subject><subject>Palmitic Acids - chemistry</subject><subject>Palmitic Acids - pharmacology</subject><subject>Stereoisomerism</subject><subject>Triglycerides - chemistry</subject><subject>Triglycerides - metabolism</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0002-9165</issn><issn>1938-3207</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU-LFDEQxRtR1nH16k0IIt56Nn86nWlvy-KqsOBFz6EmqbgZu5M26Vb8Jn5ca5hhD4KnUPV-eRTvNc1LwbeCD-oKDi5d9WKraVTmUbMRg9q1SnLzuNlwzmU7iF4_bZ7VeuBcyG7XXzQXxijFpd40f24RfUzf2FxwgmUtyBL-2ueSWEwB0lLZDOMUl-gYuOhpy2DK61GA5FldsGCONU9YCJlzJTQnVuMURyhsyWy5h4XlwO7XCRKj9fd3DENARxZEBlKPTlNMWGBkexghOXzePAkwVnxxfi-br7fvv9x8bO8-f_h0c33Xuk7ppQXfBa8VufWa-33g0gPsnOy94L4bvNSohTNgTDdwvled6DSGnRxUkM75oC6btyffueQfK9bFTrE6HOkIzGu1xlBkFDSBr_8BD3ktiW6zUolBis5ogrYnyJVca8Fg5xInKL-t4PbYlz32ZXthtT32RR9enV3X_YT-AT8XRPqbsw7VwRgKZRPrA6a0MHwQhO1OGFJUPyMWW11EitHHQkFbn-P_LvgL3X20Jw</recordid><startdate>19950501</startdate><enddate>19950501</enddate><creator>Carnielli, VP</creator><creator>Luijendijk, IH</creator><creator>van Goudoever, JB</creator><creator>Sulkers, EJ</creator><creator>Boerlage, AA</creator><creator>Degenhart, HJ</creator><creator>Sauer, PJ</creator><general>Elsevier Inc</general><general>American Society for Clinical Nutrition</general><general>American Society for Clinical Nutrition, Inc</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7T7</scope><scope>7TS</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>19950501</creationdate><title>Feeding premature newborn infants palmitic acid in amounts and stereoisomeric position similar to that of human milk: effects on fat and mineral balance</title><author>Carnielli, VP ; Luijendijk, IH ; van Goudoever, JB ; Sulkers, EJ ; Boerlage, AA ; Degenhart, HJ ; Sauer, PJ</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c435t-ad4fd53fec650dbf02daa8c26d10d49d25e51c7a774900b34145ef8293f2ccdf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Administration, Oral</topic><topic>Babies</topic><topic>Baby foods</topic><topic>Biological and medical sciences</topic><topic>Calcium</topic><topic>Calcium - pharmacokinetics</topic><topic>Clinical trials</topic><topic>Cross-Over Studies</topic><topic>Fatty Acids - administration & dosage</topic><topic>Fatty Acids - analysis</topic><topic>Fatty Acids - pharmacokinetics</topic><topic>Feces - chemistry</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Infant Food - standards</topic><topic>Infant Nutritional Physiological Phenomena</topic><topic>Infant, Newborn</topic><topic>Infant, Premature - metabolism</topic><topic>Infant, Premature - physiology</topic><topic>Intestinal Absorption</topic><topic>Lipid Metabolism</topic><topic>Lipids</topic><topic>Milk, Human - chemistry</topic><topic>Milk, Human - physiology</topic><topic>Minerals - metabolism</topic><topic>Nutrition</topic><topic>Palmitic Acid</topic><topic>Palmitic Acids - administration & dosage</topic><topic>Palmitic Acids - chemistry</topic><topic>Palmitic Acids - pharmacology</topic><topic>Stereoisomerism</topic><topic>Triglycerides - chemistry</topic><topic>Triglycerides - metabolism</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carnielli, VP</creatorcontrib><creatorcontrib>Luijendijk, IH</creatorcontrib><creatorcontrib>van Goudoever, JB</creatorcontrib><creatorcontrib>Sulkers, EJ</creatorcontrib><creatorcontrib>Boerlage, AA</creatorcontrib><creatorcontrib>Degenhart, HJ</creatorcontrib><creatorcontrib>Sauer, PJ</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Physical Education Index</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of clinical nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carnielli, VP</au><au>Luijendijk, IH</au><au>van Goudoever, JB</au><au>Sulkers, EJ</au><au>Boerlage, AA</au><au>Degenhart, HJ</au><au>Sauer, PJ</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Feeding premature newborn infants palmitic acid in amounts and stereoisomeric position similar to that of human milk: effects on fat and mineral balance</atitle><jtitle>The American journal of clinical nutrition</jtitle><addtitle>Am J Clin Nutr</addtitle><date>1995-05-01</date><risdate>1995</risdate><volume>61</volume><issue>5</issue><spage>1037</spage><epage>1042</epage><pages>1037-1042</pages><issn>0002-9165</issn><eissn>1938-3207</eissn><coden>AJCNAC</coden><abstract>The effect of the structure of human milk triglycerides on intestinal fat absorption remains controversial. Twelve infants were each fed, for 1 wk in a crossover design, two formulas that differed only in triglyceride configuration. The "beta" formula contained triglycerides similar to those in human milk (26% palmitic acid, esterified predominantly to the sn-2 position) whereas in the "alpha" formula, which contained triglycerides similar to those in formulas currently marketed, palmitate was mainly at the sn-1,3 positions. Fatty acid, fat, and mineral balances were measured at the end of each 1-wk period. Myristic, palmitic, and stearic acids were absorbed better from the beta formula, but total fat excretion was not reduced. During the feeding of beta formula fecal calcium excretion was lower, urinary calcium higher, and urinary phosphate lower. A formula containing triglycerides similar to those in human milk has significant effects on fatty acid intestinal absorption and improves mineral balance in comparison with a conventional formula.</abstract><cop>Bethesda, MD</cop><pub>Elsevier Inc</pub><pmid>7733025</pmid><doi>10.1093/ajcn/61.5.1037</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The American journal of clinical nutrition, 1995-05, Vol.61 (5), p.1037-1042 |
| issn | 0002-9165 1938-3207 |
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| subjects | Administration, Oral Babies Baby foods Biological and medical sciences Calcium Calcium - pharmacokinetics Clinical trials Cross-Over Studies Fatty Acids - administration & dosage Fatty Acids - analysis Fatty Acids - pharmacokinetics Feces - chemistry Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Humans Infant Food - standards Infant Nutritional Physiological Phenomena Infant, Newborn Infant, Premature - metabolism Infant, Premature - physiology Intestinal Absorption Lipid Metabolism Lipids Milk, Human - chemistry Milk, Human - physiology Minerals - metabolism Nutrition Palmitic Acid Palmitic Acids - administration & dosage Palmitic Acids - chemistry Palmitic Acids - pharmacology Stereoisomerism Triglycerides - chemistry Triglycerides - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Feeding premature newborn infants palmitic acid in amounts and stereoisomeric position similar to that of human milk: effects on fat and mineral balance |
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