Pharmacological properties of NK433, a new centrally acting muscle relaxant

The pharmacological properties of NK433 ((−)-( R)-2-methyl-3-(1-pyrrolidinyl)-4'-trifluoromethylpropiophenone monohydrochloride), a novel muscle relaxant, were investigated. NK433 inhibited intercollicular decerebrate rigidity (γ-rigidity) and anemic decerebrate rigidity (α-rigidity) dose depen...

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Veröffentlicht in:	European journal of pharmacology 1995-01, Vol.273 (1), p.47-56
Hauptverfasser:	Sakitama, Katsuhiko, Ozawa, Yoshihito, Aoto, Naomi, Nakamura, Keiko, Ishikawa, Michio
Format:	Artikel
Sprache:	eng
Schlagworte:	Analgesics - pharmacology Animals Biological and medical sciences Decerebrate rigidity Dose-Response Relationship, Drug In Vitro Techniques Male Medical sciences Mice Mice, Inbred ICR Morphine - pharmacology Muscle Muscle Contraction - drug effects Muscle Denervation Muscle relaxant, centrally acting Muscle Relaxants, Central - pharmacology Muscle Rigidity - drug therapy Muscle Spindles - drug effects Muscle Tonus - drug effects NK433 Pain Measurement - drug effects Pharmacology. Drug treatments Propiophenones - pharmacology Pyrrolidines - pharmacology Rats Rats, Wistar Straub tail reaction Synaptic Transmission - drug effects Tolperisone - pharmacology γ-Activity
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