Three distinct IL-2 signaling pathways mediated by bcl-2, c- myc, and lck cooperate in hematopoietic cell proliferation
Two interleukin-2 receptor-dependent signaling pathways have thus far been identified: the c-fos/c- jun induction pathway mediated by src family protein-tyrosine kinases and the c- myc induction pathway. Here, we provide evidence for the existence of a third, rapamycin-sensitive pathway, which- resu...
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| Veröffentlicht in: | Cell 1995-04, Vol.81 (2), p.223-231 |
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| container_title | Cell |
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| creator | Miyazaki, Tadaaki Liu, Zhao-Jun Kawahara, Atsuo Minami, Yasuhiro Yamada, Kyoko Tsujimoto, Yoshihide Barsoumian, Edward L Perlmutter, Roger M Taniguchi, Tadatsugu |
| description | Two interleukin-2 receptor-dependent signaling pathways have thus far been identified: the
c-fos/c-
jun induction pathway mediated by
src family protein-tyrosine kinases and the c-
myc induction pathway. Here, we provide evidence for the existence of a third, rapamycin-sensitive pathway, which- results in the induction of another proto-oncogene,
bcl-2. In the hematopoietic cell line BAF-1303, the expression of any two of
lckF505 (an active form of [56
lck
), Bcl-2, or c-Myc is sufficient to promote transit of the cell cycle, regardless of the activation state of the third pathway. We also provide evidence that epidermal growth factor receptor signaling may act through the same pathway that involves [56
lck
. These studies demonstrate a novel approach to dissecting signaling pathways regulating cellular proliferation. |
| doi_str_mv | 10.1016/0092-8674(95)90332-1 |
| format | Article |
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c-fos/c-
jun induction pathway mediated by
src family protein-tyrosine kinases and the c-
myc induction pathway. Here, we provide evidence for the existence of a third, rapamycin-sensitive pathway, which- results in the induction of another proto-oncogene,
bcl-2. In the hematopoietic cell line BAF-1303, the expression of any two of
lckF505 (an active form of [56
lck
), Bcl-2, or c-Myc is sufficient to promote transit of the cell cycle, regardless of the activation state of the third pathway. We also provide evidence that epidermal growth factor receptor signaling may act through the same pathway that involves [56
lck
. These studies demonstrate a novel approach to dissecting signaling pathways regulating cellular proliferation.</description><identifier>ISSN: 0092-8674</identifier><identifier>EISSN: 1097-4172</identifier><identifier>DOI: 10.1016/0092-8674(95)90332-1</identifier><identifier>PMID: 7736574</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; Apoptosis - physiology ; B-Lymphocytes - drug effects ; B-Lymphocytes - physiology ; Cell Division - drug effects ; Epidermal Growth Factor - pharmacology ; ErbB Receptors - metabolism ; Gene Expression Regulation - drug effects ; Hematopoietic Stem Cells - drug effects ; Hematopoietic Stem Cells - physiology ; Interleukin-2 - pharmacology ; Lymphocyte Specific Protein Tyrosine Kinase p56(lck) ; Mice ; Models, Biological ; Oncogene Proteins - genetics ; Oncogene Proteins - metabolism ; Polyenes - pharmacology ; Protein-Tyrosine Kinases - genetics ; Protein-Tyrosine Kinases - metabolism ; Proto-Oncogene Proteins - genetics ; Proto-Oncogene Proteins - metabolism ; Proto-Oncogene Proteins c-bcl-2 ; Proto-Oncogene Proteins c-myc - genetics ; Proto-Oncogene Proteins c-myc - metabolism ; Signal Transduction - physiology ; Sirolimus</subject><ispartof>Cell, 1995-04, Vol.81 (2), p.223-231</ispartof><rights>1995</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3841-90d6b5386202b8f610a9cbed1bdf4a5a54cb2ba352b63396034f269f95522af93</citedby><cites>FETCH-LOGICAL-c3841-90d6b5386202b8f610a9cbed1bdf4a5a54cb2ba352b63396034f269f95522af93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0092-8674(95)90332-1$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>315,781,785,3551,27929,27930,46000</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7736574$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Miyazaki, Tadaaki</creatorcontrib><creatorcontrib>Liu, Zhao-Jun</creatorcontrib><creatorcontrib>Kawahara, Atsuo</creatorcontrib><creatorcontrib>Minami, Yasuhiro</creatorcontrib><creatorcontrib>Yamada, Kyoko</creatorcontrib><creatorcontrib>Tsujimoto, Yoshihide</creatorcontrib><creatorcontrib>Barsoumian, Edward L</creatorcontrib><creatorcontrib>Perlmutter, Roger M</creatorcontrib><creatorcontrib>Taniguchi, Tadatsugu</creatorcontrib><title>Three distinct IL-2 signaling pathways mediated by bcl-2, c- myc, and lck cooperate in hematopoietic cell proliferation</title><title>Cell</title><addtitle>Cell</addtitle><description>Two interleukin-2 receptor-dependent signaling pathways have thus far been identified: the
c-fos/c-
jun induction pathway mediated by
src family protein-tyrosine kinases and the c-
myc induction pathway. Here, we provide evidence for the existence of a third, rapamycin-sensitive pathway, which- results in the induction of another proto-oncogene,
bcl-2. In the hematopoietic cell line BAF-1303, the expression of any two of
lckF505 (an active form of [56
lck
), Bcl-2, or c-Myc is sufficient to promote transit of the cell cycle, regardless of the activation state of the third pathway. We also provide evidence that epidermal growth factor receptor signaling may act through the same pathway that involves [56
lck
. These studies demonstrate a novel approach to dissecting signaling pathways regulating cellular proliferation.</description><subject>Animals</subject><subject>Apoptosis - physiology</subject><subject>B-Lymphocytes - drug effects</subject><subject>B-Lymphocytes - physiology</subject><subject>Cell Division - drug effects</subject><subject>Epidermal Growth Factor - pharmacology</subject><subject>ErbB Receptors - metabolism</subject><subject>Gene Expression Regulation - drug effects</subject><subject>Hematopoietic Stem Cells - drug effects</subject><subject>Hematopoietic Stem Cells - physiology</subject><subject>Interleukin-2 - pharmacology</subject><subject>Lymphocyte Specific Protein Tyrosine Kinase p56(lck)</subject><subject>Mice</subject><subject>Models, Biological</subject><subject>Oncogene Proteins - genetics</subject><subject>Oncogene Proteins - metabolism</subject><subject>Polyenes - pharmacology</subject><subject>Protein-Tyrosine Kinases - genetics</subject><subject>Protein-Tyrosine Kinases - metabolism</subject><subject>Proto-Oncogene Proteins - genetics</subject><subject>Proto-Oncogene Proteins - metabolism</subject><subject>Proto-Oncogene Proteins c-bcl-2</subject><subject>Proto-Oncogene Proteins c-myc - genetics</subject><subject>Proto-Oncogene Proteins c-myc - metabolism</subject><subject>Signal Transduction - physiology</subject><subject>Sirolimus</subject><issn>0092-8674</issn><issn>1097-4172</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1995</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtP3DAURq0KRKe0_4BKXiEqYfA78QYJobYgjcQG1pbt3DCmSZzamaL59006I5Zd3cV37usgdMboFaNMX1NqOKl1JS-M-maoEJywD2jFqKmIZBU_Qqt35CP6VMorpbRWSp2gk6oSWlVyhd6eNhkAN7FMcQgTflgTjkt8GVwXhxc8umnz5nYF99BEN0GD_Q770BF-iQPB_S5cYjc0uAu_cEhphDxDOA54A72b0pgiTDHgAF2Hx5y62C5ETMNndNy6rsCXQz1Fzz--P93dk_Xjz4e72zUJopaMGNpor0StOeW-bjWjzgQPDfNNK51ySgbPvROKey2E0VTIlmvTGqU4d60Rp-h8P3fe_nsLZbJ9LMs5boC0LbaquFSCqhmUezDkVEqG1o459i7vLKN28W0XmXaRaY2y_3xbNrd9Pczf-tnRe9NB8Jzf7HOYn_wTIdsSIgxh1pkhTLZJ8f8L_gJSVo7H</recordid><startdate>19950421</startdate><enddate>19950421</enddate><creator>Miyazaki, Tadaaki</creator><creator>Liu, Zhao-Jun</creator><creator>Kawahara, Atsuo</creator><creator>Minami, Yasuhiro</creator><creator>Yamada, Kyoko</creator><creator>Tsujimoto, Yoshihide</creator><creator>Barsoumian, Edward L</creator><creator>Perlmutter, Roger M</creator><creator>Taniguchi, Tadatsugu</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19950421</creationdate><title>Three distinct IL-2 signaling pathways mediated by bcl-2, c- myc, and lck cooperate in hematopoietic cell proliferation</title><author>Miyazaki, Tadaaki ; Liu, Zhao-Jun ; Kawahara, Atsuo ; Minami, Yasuhiro ; Yamada, Kyoko ; Tsujimoto, Yoshihide ; Barsoumian, Edward L ; Perlmutter, Roger M ; Taniguchi, Tadatsugu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3841-90d6b5386202b8f610a9cbed1bdf4a5a54cb2ba352b63396034f269f95522af93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1995</creationdate><topic>Animals</topic><topic>Apoptosis - physiology</topic><topic>B-Lymphocytes - drug effects</topic><topic>B-Lymphocytes - physiology</topic><topic>Cell Division - drug effects</topic><topic>Epidermal Growth Factor - pharmacology</topic><topic>ErbB Receptors - metabolism</topic><topic>Gene Expression Regulation - drug effects</topic><topic>Hematopoietic Stem Cells - drug effects</topic><topic>Hematopoietic Stem Cells - physiology</topic><topic>Interleukin-2 - pharmacology</topic><topic>Lymphocyte Specific Protein Tyrosine Kinase p56(lck)</topic><topic>Mice</topic><topic>Models, Biological</topic><topic>Oncogene Proteins - genetics</topic><topic>Oncogene Proteins - metabolism</topic><topic>Polyenes - pharmacology</topic><topic>Protein-Tyrosine Kinases - genetics</topic><topic>Protein-Tyrosine Kinases - metabolism</topic><topic>Proto-Oncogene Proteins - genetics</topic><topic>Proto-Oncogene Proteins - metabolism</topic><topic>Proto-Oncogene Proteins c-bcl-2</topic><topic>Proto-Oncogene Proteins c-myc - genetics</topic><topic>Proto-Oncogene Proteins c-myc - metabolism</topic><topic>Signal Transduction - physiology</topic><topic>Sirolimus</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Miyazaki, Tadaaki</creatorcontrib><creatorcontrib>Liu, Zhao-Jun</creatorcontrib><creatorcontrib>Kawahara, Atsuo</creatorcontrib><creatorcontrib>Minami, Yasuhiro</creatorcontrib><creatorcontrib>Yamada, Kyoko</creatorcontrib><creatorcontrib>Tsujimoto, Yoshihide</creatorcontrib><creatorcontrib>Barsoumian, Edward L</creatorcontrib><creatorcontrib>Perlmutter, Roger M</creatorcontrib><creatorcontrib>Taniguchi, Tadatsugu</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cell</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Miyazaki, Tadaaki</au><au>Liu, Zhao-Jun</au><au>Kawahara, Atsuo</au><au>Minami, Yasuhiro</au><au>Yamada, Kyoko</au><au>Tsujimoto, Yoshihide</au><au>Barsoumian, Edward L</au><au>Perlmutter, Roger M</au><au>Taniguchi, Tadatsugu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Three distinct IL-2 signaling pathways mediated by bcl-2, c- myc, and lck cooperate in hematopoietic cell proliferation</atitle><jtitle>Cell</jtitle><addtitle>Cell</addtitle><date>1995-04-21</date><risdate>1995</risdate><volume>81</volume><issue>2</issue><spage>223</spage><epage>231</epage><pages>223-231</pages><issn>0092-8674</issn><eissn>1097-4172</eissn><abstract>Two interleukin-2 receptor-dependent signaling pathways have thus far been identified: the
c-fos/c-
jun induction pathway mediated by
src family protein-tyrosine kinases and the c-
myc induction pathway. Here, we provide evidence for the existence of a third, rapamycin-sensitive pathway, which- results in the induction of another proto-oncogene,
bcl-2. In the hematopoietic cell line BAF-1303, the expression of any two of
lckF505 (an active form of [56
lck
), Bcl-2, or c-Myc is sufficient to promote transit of the cell cycle, regardless of the activation state of the third pathway. We also provide evidence that epidermal growth factor receptor signaling may act through the same pathway that involves [56
lck
. These studies demonstrate a novel approach to dissecting signaling pathways regulating cellular proliferation.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7736574</pmid><doi>10.1016/0092-8674(95)90332-1</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0092-8674 |
| ispartof | Cell, 1995-04, Vol.81 (2), p.223-231 |
| issn | 0092-8674 1097-4172 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_77245305 |
| source | MEDLINE; Cell Press Free Archives; Access via ScienceDirect (Elsevier); EZB-FREE-00999 freely available EZB journals |
| subjects | Animals Apoptosis - physiology B-Lymphocytes - drug effects B-Lymphocytes - physiology Cell Division - drug effects Epidermal Growth Factor - pharmacology ErbB Receptors - metabolism Gene Expression Regulation - drug effects Hematopoietic Stem Cells - drug effects Hematopoietic Stem Cells - physiology Interleukin-2 - pharmacology Lymphocyte Specific Protein Tyrosine Kinase p56(lck) Mice Models, Biological Oncogene Proteins - genetics Oncogene Proteins - metabolism Polyenes - pharmacology Protein-Tyrosine Kinases - genetics Protein-Tyrosine Kinases - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Proto-Oncogene Proteins c-bcl-2 Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism Signal Transduction - physiology Sirolimus |
| title | Three distinct IL-2 signaling pathways mediated by bcl-2, c- myc, and lck cooperate in hematopoietic cell proliferation |
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