Protective effects of HOE642, a selective sodium-hydrogen exchange subtype 1 inhibitor, on cardiac ischaemia and reperfusion

The aim was to characterise the new compound HOE642 as a selective and cardioprotective Na+/H+ exchange inhibitor in various models. The effect of HOE642 was tested in the osmotically activated Na+/H+ exchange of rabbit erythrocytes and in propionate induced swelling of human thrombocytes. Recovery...

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Veröffentlicht in:	Cardiovascular research 1995-02, Vol.29 (2), p.260-268
Hauptverfasser:	SCHOLZ, W, ALBUS, U, COUNILLON, L, GÖGELEIN, H, LANG, H.-J, LINZ, W, WEICHERT, A, SCHÖLKENS, B. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antianginal agents. Coronary vasodilator agents Biological and medical sciences Blood Platelets - drug effects Blood Platelets - metabolism Cardiovascular system Cells, Cultured Dose-Response Relationship, Drug Erythrocytes - cytology Erythrocytes - drug effects Erythrocytes - metabolism Guanidines - pharmacology Hydrogen-Ion Concentration Male Medical sciences Myocardial Ischemia - metabolism Myocardial Reperfusion Injury - prevention & control Myocardium - cytology Myocardium - metabolism Perfusion Pharmacology. Drug treatments Rabbits Rats Rats, Sprague-Dawley Sodium-Hydrogen Exchangers - antagonists & inhibitors Sodium-Hydrogen Exchangers - metabolism Sulfones - pharmacology
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